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A graph from Gordon Moore’s “The Future of Integrated...

A graph from Gordon Moore’s “The Future of Integrated Electronics” from 1965: an article that lays out Moore’s belief that the number of transistors on a microchip would double every year. Click here to read the entire paper. Come back Wednesday to see a circuit board from CHF’s collections and learn about how Intel built the first computer chip.

Moore’s Law: A Silicon Story

Moore’s law is an insight into change, into the forces behind developments in silicon electronics—microchips—and their far-reaching consequences. In the early 1960s a young physical chemist named Gordon E. Moore had been at work for several years on the technology for making miniature electronic switches, called transistors. Show More Summary

One person’s half used bar of hotel soap could be another person’s best chance to survive?

On my list of things I could donate that I would consider life saving, I would put blood, organs, bone marrow, even clean water. Half used bars of hotel soap? That never crossed my mind. It did to Shawn Seipler, now the CEO of the nonprofit initiative called Clean the World. Show More Summary

If it works don't mess with it!

I'm currently in Brussels vistiting a collaborator. The research groups lab is absolutely fascinating and contains several old school mechanical contraptions that do a great job.For your glassware drying pleasures:For melting point determination...Show More Summary


This is what 40 g of the depicted indole looks like after one recrystallisation. It really shouldn't be green but it is very pretty and even better it's analytically pure. D!Okay, okay people. Is the photo more to your satisfaction?...

Catalytic Hydrogenation Part II - Tips and Tricks

Well since I appear to be suffering from insomnia I may as well blog a bit. It's about time anyway.All synthetic organic chemists will eventually be facing a catalytic hydrogenation. Catalytic hydrogenations are great because they are easy to perform, generally work well and it allows you to do a fair bit of rather useful chemistry. Show More Summary

Gordon Moore (the chemist, not the musicians from Sonic Youth)...

Gordon Moore (the chemist, not the musicians from Sonic Youth) is coming to the Distillations blog. Every day next week we’ll post something about Moore and his law—his prediction that the number of transistors that fit on a microchip would double every year (a prediction Moore revised to doubling every two years in 1975). Show More Summary

The Sand Bath - An Alternative to the Oil Bath

Yes, I am still alive! I have been out of the lab for a loooong time so the inspiration hasn't been there. However, I am now finding myself in the lab again and it appears that I will get to stay there for a while. And today inspiration struck.Let's talk about oil baths. Show More Summary

PhD in Medicinal Chemistry

Design and synthesis of the first selective ligands for the GPRC6A receptor – a novel human G-protein coupled receptor with unknown physiological functionMore info at this web site.DO NOT email us but please follow the application procedure at the bottom of this web page.There are links to all necessary information on the same web page.D!

100th Anniversary

Wow, I just realised that I've passed the 100 posts mark a while back.-The Coffee Break section has been updated with a new comic website called The Perry Bible Fellowship. Fantastic stuff that you really should check out. Also there's been a fair bit of activity at Electra Lady Land so that's worth a visit if your into the arty stuff. D!

Hard Science

There's some seriously hard science in the latest issue of ChemComm. D!

A molecular modeler to his beloved (medicinal chemist)

With all apologies to W. B. Yeats Original:"I BRING you with reverent hands The books of my numberless dreams; White woman that passion has worn As the tide wears the dove-gray sands, And with heart more old than the horn That is brimmed...Show More Summary

A few weeks ago the Distillations team was fortunate enough to...

A few weeks ago the Distillations team was fortunate enough to have lunch with Ivan Amato and Kirk Wolfinger. While discussing the security clearance required to film a documentary on a nuclear submarine, Wolfinger brought up the story of how Tom Clancy wrote The Hunt for Red October, a novel about a fictitious U.S. Show More Summary

We need new models of popular physics communication

One of the issues I have with Steven Weinberg's list of 13 science books is that they showcase a very specific model of science writing - that of straight explanation and historical exposition. Isaac Asimov was very good at this model, so was George Gamow. Show More Summary

If computational recipes were like food recipes...

...the menu at Boston's elegant L'Espalier might look something like this. Maine beef tenderloin: Carrot tagliatelle al ragù, gorgonzola mornay, sunny side up quail egg, crispy shallots 10 ns molecular dynamics run: Replica exchange, orthorhombic box, embedded sodium ions, 1 fs time step, Nose-Hoover thermostat. Show More Summary

Top 10 popular chemistry books for the general reader

An aerogel, one of the wonders of modern chemistrydescribed by Mark Miodownik in "Stuff Matters" Steven Weinberg - with whom I once had the great pleasure of sharing a panel on 'Big Science' - has noted a list of 13 of his favorite science books for the general reader in an interview with The Guardian. Show More Summary

Distillations Podcast: Fads and Faith: Belief vs. Fact in the Struggle for Health

In 2014 the United States had 650 reported cases of measles, a disease made preventable by a vaccine introduced 30 years ago. The majority of those who caught the measles were children whose parents chose not to vaccinate them. Meanwhile...Show More Summary

In drug discovery, what counts is asking the right question

The other day I was having a discussion with a colleague about the drug Velcade which has been used quite successfully to treat multiple myeloma. Velcade is probably the only bestselling drug that has the element boron in it. Boron is a highly reactive element that had never been seen in drugs before. Show More Summary

"In surprise advance announcement, 2013 Nobel Prize in physics awarded to Higgs boson"

In honor of April Fool's day I am posting an old post from Scientific American which I wrote not on April 1st but on September 30th, a few days before the announcement of the Nobel Prize awarded that year for the prediction of the Higgs Boson. Show More Summary

In the 1800s advances in preservation technology allowed foods...

In the 1800s advances in preservation technology allowed foods to travel farther and sit on shelves longer. Canning, processing, and refrigeration let people eat such foods as tuna no matter how far they lived from the ocean. But processed food came at a cost: most of it tasted bland. Show More Summary

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