Recent studies showing acid ceramidase (AC) to be upregulated in melanoma, lung and prostate cancers have made the enzyme a desired target for novel synthetic inhibitor compounds. Now scientists describe the very first class of AC inhibitors that may aid in the efficacy of chemotherapies.
Researchers are using time-lapse photography, linked to weather data, to study climate and geological change in the Antarctic Dry Valleys.
NASA's reprocessed picture of Jupiter's Europa gives us a fresh look at the likeliest place in the solar system for extraterrestrial life.
Move over, poop cruise. There's a new poop-related form of transport on the road, and this one is more neat than nasty. A "Bio-Bus" that runs solely on the biomethane gas generated by treated waste (of the food and human variety) is up and running as of this week in...
A comprehensive analysis of children's rights in 190 countries around the world has now been released. Today, the Convention on the Rights of the Child remains the only formal global effort to improve children's rights and the most widely ratified human rights treaty in history. Show More Summary
A new discovery about the atomic structure of uranium dioxide will help scientists select the best computational model to simulate severe nuclear reactor accidents.
Scientists reveal details about carbon deep beneath Earth’s surface and suggest ways it might have influenced the history of life on the planet.
The Self-Sufficiency Standard for Washington State 2014 report finds that the costs of meeting basic needs have far outstripped wages statewide, particularly for families. The study found that Washington families with two adults, a preschooler...Show More Summary
A link between moms' employment and overweight/obesity in preschoolers has been found by researchers. The study investigated links between mothers' employment status and their children's weight over time, exploring the impact of potential mediators, such as children's sleep and dietary habits, the amount of time they spent watching TV and family mealtime routines.
A potential path to identify imperfections and improve the quality of nanomaterials for use in next-generation solar cells has just emerged.
Researchers are taking a unique approach to understanding and investigating cancer by utilizing evolutionary principles and computational modeling to examine the role of specific genetic mutations in the Darwinian struggle among tumor and normal cells during cancer growth.
A new device contains a form of vitamin A that controls inflammatory responses, preventing scar tissue formation and promoting wound healing. The soft, porous, and thin elastic material contains an acid form of vitamin A, called a retinoid, which is produced by the body to help cells develop and stay healthy. Show More Summary
In many firms sales people spend as much time negotiating internally for lower prices as they do interacting with customers. A new study finds that firms should allow their sales people to 'waste' energy on internal negotiations. In fact, it says, firms should make the process wasteful on purpose.
A survey of older adults in eleven countries found that Americans were sicker than their counterparts abroad, with 68 percent living with two or more chronic conditions and 53 percent taking four or more medications. More Americans,Show More Summary
Drugs that have been used for the past 30 years to treat HIV/AIDS, could be repurposed to treat the dry form of age-related macular degeneration (AMD), a new study suggests. AMD is a progressive condition that is untreatable in up to 90 percent of patients and is a leading cause of blindness in the elderly worldwide. Show More Summary
Research published today found that the investigational drug patiromer decreased high potassium levels and maintained normal potassium levels in patients with chronic kidney disease. The results of a multicenter trial appear in the New...Show More Summary
Scientists know that humans were kicking around the lower altitudes of the Tibetan Peninsula around 10,000 years ago. Permanent settlements, however, didn't show up in the harsh higher altitudes until 3,600 years ago. What happened that allowed ancient settlers to survive in a region nicknamed the "roof of...
Scientists have discovered an ancient, deep canyon buried along the Yarlung Tsangpo River in south Tibet, north of the eastern end of the Himalayas. The geologists say that the ancient canyon -- thousands of feet deep in places -- effectively rules out a popular model used to explain how the massive and picturesque gorges of the Himalayas became so steep, so fast.
Doctors have long been mystified as to why HIV-1 rapidly sickens some individuals, while in others the virus has difficulties gaining a foothold. Now, a study of genetic variation in HIV-1 and in the cells it infects has uncovered a chink in HIV-1's armor that may, at least in part, explain the puzzling difference -- and potentially open the door to new treatments.
Archaeological findings pose questions about genetic resistance in humans to altitude sickness and genetic response in crop plants to flowering times and ultraviolet radiation tolerance. Archaeological discoveries from the 'roof of the...Show More Summary