Blog Profile / Fight Aging


URL :http://www.fightaging.org
Filed Under:Health / Aging
Posts on Regator:4182
Posts / Week:11.6
Archived Since:April 26, 2008

Blog Post Archive

A Tour of Pharmaceuticals that Extend Life in Nematodes

yesterdayHealth / Aging : Fight Aging

Most threads of aging research start in studies of very short-lived species, most commonly the nematode worm C. elegans. These animals are cheap to maintain over the course of a study, live for only a few weeks, and are probably better understood at the cellular and genetic level than any other species. Show More Summary

Myostatin Insufficiency Produces 15% Life Extension in Mice

2 days agoHealth / Aging : Fight Aging

Targeting myostatin and related biochemistry is well demonstrated to increase muscle mass and strength in mammals such as laboratory mice. There are even rare natural mutants, including a few cows and humans, who lack normal myostatin and are as a result exceptionally strong in comparison to their peers. Show More Summary

Leucine Supplementation as a Sarcopenia Treatment

2 days agoHealth / Aging : Fight Aging

The systematic loss of muscle mass and strength with age is given the name sarcopenia. One of the potential contributing causes involves progressive dysfunction in processing of the amino acid leucine, and this might in theory be partially offset by leucine supplementation in the diet. Show More Summary

Genes Become Increasingly Important in Extreme Old Age

2 days agoHealth / Aging : Fight Aging

The lesson to take away from the last fifteen years of study of the genetics of longevity is that genetic variation in humans is simply not all that important throughout most of life. Aging is caused by damage, and certainly during the...Show More Summary

A New Era of Aging Research

2 days agoHealth / Aging : Fight Aging

Using the recent development of killifish as a model organism as a starting point, this popular science article looks at some of the more recent high profile developments in the study of aging. It largely takes the longevity dividend party line of talking about extending healthy life span without extending overall life span, however. Show More Summary

Further Investigations of Neuropeptide Y and the Hypothalamus in Calorie Restriction

3 days agoHealth / Aging : Fight Aging

A number of lines of research suggest that the benefits of calorie restriction for health and longevity largely derive from increased cellular housekeeping processes such as autophagy. For example, the calorie restriction response requires neuropeptide Y (NPY), and here researchers explore the linkage of NPY with autophagy. Show More Summary

Excess Fat is Bad, Intentional Loss of that Fat is Good

3 days agoHealth / Aging : Fight Aging

One of the things that turns up in large sets of data on weight and mortality - by which I really mean amount of fat tissue and mortality - is that both maintaining excess fat tissue and later the loss of that fat tissue are associated with increased mortality. Show More Summary

Education Correlates With Longevity

4 days agoHealth / Aging : Fight Aging

It is known that greater educational achievement is associated with greater longevity, and this is one facet of a web of related correlations between various measures of intelligence, wealth, and health. To my eyes this probably allShow More Summary

Who Funds Basic Aging Research in the US?

4 days agoHealth / Aging : Fight Aging

Here is an interesting post from the Buck Institute on sources of funding for fundamental research into aging, with tables listing the various contributing organizations. While looking through the list, it is worth bearing in mind that for really early stage, high risk, novel research the largest sources are unavailable. Show More Summary

More Signs that Calico Will Fund Broad Mainstream Drug Discovery and Genetic Research

4 days agoHealth / Aging : Fight Aging

Google is pouring a large amount of money into aging research via the Calico Labs initiative. Their declared aim is to produce treatments that impact the whole of age-related degeneration, and their open support of that goal is certainly...Show More Summary

The "Aging Kills" Initiative

5 days agoHealth / Aging : Fight Aging

A number of the efforts undertaken by the ever industrious Alex Zhavoronkov of InSilico Medicine involve reaching out into new communities to educate and raise awareness on the need for longevity science and the prospects for developing the means to treat aging. Show More Summary

Another Study to Argue that Tau is Primary and Amyloid Secondary in Alzheimer's Disease

5 days agoHealth / Aging : Fight Aging

The struggle to show meaningful progress in treatment of Alzheimer's disease via clearance of amyloid has fueled significant investment into alternative hypotheses regarding the disease process. The biochemistry of Alzheimer's - andShow More Summary

DNA Methylation and Natural Variation in Human Longevity

5 days agoHealth / Aging : Fight Aging

DNA methylation is an epigenetic alteration in which genes are decorated with methyl groups. It is one of a range of epigenetic processes that establish a feedback loop linking the pace at which specific proteins are built from genetic...Show More Summary

Ceria Nanoparticles Enhance Autophagy

5 days agoHealth / Aging : Fight Aging

Autophagy is one of the cellular housekeeping processes responsible for promptly clearing out damaged proteins and cell components before they cause more harm. Autophagic activity declines with age, in part due to a build up of resilient metabolic waste in lysosomes, the organelles responsible for breaking down materials and structures for recycling. Show More Summary

Theorizing that the Brain is Destroyed by the Pulse

5 days agoHealth / Aging : Fight Aging

It is uncontroversial that the age-related deterioration of the vascular system leads to damage to the brain, causing cognitive decline and then dementia. Progressive stiffening due to cross-links and calcification and inflammation-driven...Show More Summary

What Can Other Primates Teach Us About Aging and Neurodegeneration?

last weekHealth / Aging : Fight Aging

It has been said that the only thing worse than using animals in medical research is to refrain from the use of animals in medical research. It is both terrible and necessary. Throughout the modern history of medical science animal studies have been needed in order to make progress, not just in human medicine, but also veterinary medicine. Show More Summary

More SIRT7 Improves Aged Stem Cell Regenerative Capacity

last weekHealth / Aging : Fight Aging

There is comparatively little study of sirtuin 7 (SIRT7) in comparison to the better known and greatly overhyped sirtuin 1 (SIRT1). All members of the sirtuin family have broad influence over a range of fundamental cellular processes,...Show More Summary

A Novel Approach in Engineering T Cells to Attack Cancer

last weekHealth / Aging : Fight Aging

A broad range of methods are under development to engineer T cells that can selectively attack cancer cells. If aggressive enough and selective enough, the immune system should in theory be able to tame and destroy most cancers, but the devil is in the details as is always the case in these matters. Show More Summary

Tissue Engineering of Lung and Gut Sections

last weekHealth / Aging : Fight Aging

The first practical outcome of tissue engineering research is not therapies, but rather improved tools for further scientific work in this and other fields. At present the structured tissue sections created in the laboratory are largely...Show More Summary

Considering the Path to Curing Blindness

last weekHealth / Aging : Fight Aging

The most prevalent causes of blindness are degenerative and associated with aging, the result of loss of cells and structure in the retina. There are numerous other causes, including optic nerve damage that can result from trauma, but these are fortunately less common. Show More Summary

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