Blog Profile / Fight Aging

Filed Under:Health / Aging
Posts on Regator:4305
Posts / Week:10
Archived Since:April 26, 2008

Blog Post Archive

A Review of Telomerase as a Therapeutic Target

16 hours agoHealth / Aging : Fight Aging

Telomerase provides the primary mechanism by which cells lengthen their telomeres. In our species only stem cells and cancer cells do this, while in mice more types of cell use more telomerase. Telomere length determines the limit to cell divisions, a little of the length being lost each time a cell divides. Show More Summary

Building a Tau Immunotherapy that does not Increase Inflammation

yesterdayHealth / Aging : Fight Aging

Alzheimer's disease is associated with the aggregation of misfolded amyloid-? and tau proteins. The consensus position is that these aggregates are the primary cause of pathology, though the biochemistry involved is exceedingly complex and still being mapped. Show More Summary

How Extracellular Matrix Scaffolds Influence Cell Behavior in Therapies

yesterdayHealth / Aging : Fight Aging

One approach to regenerative medicine is to use donor extracellular matrix as a scaffolding material. The extracellular matrix is the support structure created by cells that determines the structural properties of a tissue. Its presence...Show More Summary

The Effects of Retirement are Complex

yesterdayHealth / Aging : Fight Aging

Whenever looking at correlations between behavior and lifespan, or behavior and health, one should always ask whether calorie intake or physical activity level could be involved. Both animal and human studies tell us that the effects...Show More Summary

A Smad7 Gene Therapy to Inhibit Age-Related Muscle Loss is in Development

2 days agoHealth / Aging : Fight Aging

There are always many ways to influence any specific process in cells and tissues. When it comes to enhanced muscle growth, the most popular approaches so far are myostatin inhibition, such as via gene knockout or the use of antibodies, or increased levels of the myostatin inhibitor follistatin. Show More Summary

GPR17 as a Target to Reduce Measures of Aging in the Brain

2 days agoHealth / Aging : Fight Aging

Researchers here note that leukotriene receptor antagonists appear to reduce inflammation and increase plasticity in the brains of rats. They pin down the receptor GPR17 as a protein of interest in this effect. While not directly addressing...Show More Summary

Exercise and TERRA in Telomere Biology

2 days agoHealth / Aging : Fight Aging

Occasionally I'll post research that is only tenuously relevant to aging, but nonetheless fascinating. That is the case for this article and open access paper on a fairly new and still poorly understood area of telomere biology. TheShow More Summary

More Details on SENS Research Foundation's ALT Cancer Program

3 days agoHealth / Aging : Fight Aging

The SENS Research Foundation is currently raising funds for the next step in its cancer research program: building one of the necessary foundations for a universal cancer therapy, one form of treatment that can in principle halt all types of cancer. Show More Summary

Stem Cell Therapy as a Potential Glaucoma Treatment

3 days agoHealth / Aging : Fight Aging

Researchers here provide evidence in mice to suggest that stem cell treatments could be used to address some forms of glaucoma, usually caused by an increase in pressure in the eye that can damage the optic nerve and other structures. Show More Summary

A Few of the More Interesting of Recent Alzheimer's Research Results

3 days agoHealth / Aging : Fight Aging

A large fraction of the public funding devoted to aging research goes towards Alzheimer's disease, a very broad set of initiatives that dovetail with other large investments in mapping and understanding the biochemistry of the brain....Show More Summary

Progress in the Use of Bioscaffolds for Muscle Regeneration

4 days agoHealth / Aging : Fight Aging

Researchers have demonstrated some restoration of strength in patients with severe muscle injuries, using scaffold materials derived from the extracellular matrix (ECM) of pig tissues. This is an incremental step forward towards theShow More Summary

Nanog May Improve Function of Old Stem Cells

4 days agoHealth / Aging : Fight Aging

In this research, the scientists involved investigate a potential role for the gene nanog in the aging of stem cells, a prospect that has been studied for a few years now. Nanog is involved in pluripotency, the ability of embryonic stem cells to generate any cell type, but, as is the case for most cellular biology, not in a straightforward way. Show More Summary

Towards a Greater Knowledge of Mitochondrial DNA Damage in Aging

4 days agoHealth / Aging : Fight Aging

Today I'll point out a very readable scientific commentary on mutations in mitochondrial DNA (mtDNA) and the importance of understanding how these mutations spread within cells. This is a topic of some interest within the field of aging research, as mitochondrial damage and loss of function is very clearly important in the aging process. Show More Summary

Further Investigation of P21 and SDF-1 Shows that Cxcr4 Inhibitors can Promote Scarless Healing in Mammals

5 days agoHealth / Aging : Fight Aging

Mice lacking p21 can regenerate small wounds without scarring, something that is not normally possible in adult mammals. Separately, SDF-1 has been identified as a signal to recruit and activate stem cells, and efforts are underway build regenerative therapies on this basis. Show More Summary

Use of Stem Cells in Bypass Therapy Reduces Scarring and Mortality

5 days agoHealth / Aging : Fight Aging

The press here reports on the positive results of a recent small trial of the introduction of stem cells during bypass surgery for heart attack survivors. Stem cell therapies have over the past decade demonstrated highly variable outcomes in patients, and the methodology of delivery has been shown to be very important. Show More Summary

Fight Aging! Newsletter, July 25th 2016

6 days agoHealth / Aging : Fight Aging

FIGHT AGING! NEWSLETTER July 25th 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent...Show More Summary

Another Set of Popular Science Articles on the Prospects for Aging Research

last weekHealth / Aging : Fight Aging

Science News recently lumped together a few popular science articles on aging research into a special issue on the subject. As the blurb notes, aging is very much neglected in comparison to its importance, and accepted despite the damage it does. Show More Summary

Killifish in Aging Research

last weekHealth / Aging : Fight Aging

Most aging research starts in short-lived species far removed from our own in the tree of life. There is a trade-off involved: it is much cheaper to explore and experiment with interventions in aging in a short-lived species, but the more distant the species the less likely that the results will be useful for longer-lived mammals. Show More Summary

AUF1 Linked to Stem Cell Function and Muscle Regeneration

last weekHealth / Aging : Fight Aging

The stem cells responsible for muscle growth and regeneration are perhaps the best studied of such populations. It seems that most of the new and interesting insights into the nuts and bolts of stem cell biology are coming from this part of the field, in any case. Show More Summary

Effective Therapies to Extend Healthy Life May Well be Widely Available for a Decade or More in Advance of Definitive Proof

last weekHealth / Aging : Fight Aging

Five years from now, it will be possible to take a trip overseas to have most of the senescent cells that have built up in your tissues cleared away via some form of drug or gene therapy treatment. That will reduce your risk of suffering...Show More Summary

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