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Blog Profile / Fight Aging


URL :http://www.fightaging.org
Filed Under:Health / Aging
Posts on Regator:4120
Posts / Week:11.5
Archived Since:April 26, 2008

Blog Post Archive

The Role of Age-Related Extracellular Matrix Restructuring in Heart Conduction Disorders

2 hours agoHealth / Aging : Fight Aging

The extracellular matrix (ECM) is the complex structure of proteins surrounding and supporting cells. The varied mechanical properties of different tissues derive from the particular arrangement and types of molecules making up this structure: the elasticity of skin and blood vessels, the load bearing resilience of bone and cartilage, and so forth. Show More Summary

The Progression of Leukemia: Most Old People Have Some of the Necessary Mutations in Blood Cells

10 hours agoHealth / Aging : Fight Aging

Here is an interesting look at the progression and prevalence of DNA damage leading to leukemia, cancers of bone marrow and white blood cells. Cancer is an age-related disease because its proximate cause is DNA damage and we accumulate ever more of this damage as time goes on. Show More Summary

Cartilage Repair Without Scaffolds

10 hours agoHealth / Aging : Fight Aging

Researchers are working on a method of delivering cells for cartilage regrowth in aged joints that doesn't use a porous scaffold in order to guide cell growth, but rather relies on the engineering of specific cell characteristics. In...Show More Summary

The Grail of Calorie Restriction Benefits Without the Calorie Restriction

23 hours agoHealth / Aging : Fight Aging

Seeking to recreate the benefits of calorie restriction - greater health and longer life - without the part of the process wherein you must eat less is a grail for modern medical research. The calorie restriction response is of greater benefit to basically healthy people than that produced by any currently available medical technology. Show More Summary

Microbes Generate Amyloid, But Is It Important in Aging?

yesterdayHealth / Aging : Fight Aging

There are a score or so of different forms of amyloid that accumulate in the aging body and brain. These are misfolded proteins that precipitate out of tissue fluids to form clumps, and the biochemistry surrounding this process can cause harm in numerous ways. Show More Summary

Presentation Videos from Rejuvenation Biotechnology 2014

yesterdayHealth / Aging : Fight Aging

Ours is an era on the verge of developing means to treat the root causes of degenerative aging and thereby extend healthy life, eliminate age-related disease, and rejuvenate the old. The decades ahead are a critical time, in which the best and most promising approaches to research and development either take off or falter. Show More Summary

Interviewing a Researcher Working on Stem Cells and Aging

yesterdayHealth / Aging : Fight Aging

Via the Buck Institute Science of Aging blog, here is a look at the work of a scientist who specializes in the intersection of the stem cell and aging fields, an area that includes cancer and regenerative research: Hematopoietic stem...Show More Summary

Reviewing What is Known of Insulin in Aging

yesterdayHealth / Aging : Fight Aging

When it comes to the mechanisms by which the operation of metabolism determines natural variations in longevity, few areas are as well studied as the role of insulin and insulin-like growth factor (IGF-1). This is no doubt in part due...Show More Summary

Grafting Tissue Engineered Muscles into Mice

yesterdayHealth / Aging : Fight Aging

Tissue engineering of muscle continues to move forward, with a new approach here demonstrated in mice: Tissue engineering of skeletal muscle is a significant challenge but has considerable potential for the treatment of the various types of irreversible damage to muscle that occur in diseases like Duchenne muscular dystrophy. Show More Summary

Greater Ageism Correlates with Greater Ability to Treat the Consequences of Aging

last weekHealth / Aging : Fight Aging

All societies have a complex relationship with aging and the old, but in the English-language Western cultures that I'm most familiar with it seems especially convoluted and strange. Individualism and a high value placed on future potential...Show More Summary

Camelid Antibodies in Cancer Targeting

last weekHealth / Aging : Fight Aging

One approach to targeting cancer cells for destruction is to employ viruses as the kill mechanism, coupled with antibodies that can discern the type of cell to kill. The ideal outcome is that viruses infect only cancer cells, multiply...Show More Summary

Investigating Epigenetic Drift in Aging

last weekHealth / Aging : Fight Aging

Epigenetics is the study of dynamic alterations to DNA that affect the rate at which specific proteins are generated from its blueprint, but do not change the blueprint itself. One example is DNA methylation, the decoration of DNA with methyl groups. Show More Summary

An Examination of Recent Historical Variability in Life Spans

last weekHealth / Aging : Fight Aging

The long upward trend in human life expectancy derives from progress in medicine in its broadest definition. The varied technologies and techniques involved have very different contributions to the shape of life expectancy, however.Show More Summary

Tissue Engineered Bone Marrow Creates Functional Blood Cells

last weekHealth / Aging : Fight Aging

Scientists continue to make progress in this first phase of tissue engineering, in which real and mock tissues of various types grown from cells will largely be used to expand and speed up further research rather than in treatment: Researchers...Show More Summary

An Update on Efforts to Use Chimeric Antigen Receptor T-Cells as a Treatment for Cancer

last weekHealth / Aging : Fight Aging

Engineering a patient's own T-cells to express chimeric antigen receptors (CARs) has shown considerable promise as a cancer treatment. This alteration steers the immune cells to attack tumor cells, and has for example been used to drive leukemia into remission in trials. Show More Summary

Targeting Anti-Inflammatory Drugs Directly to Atherosclerotic Lesions in Blood Vessel Walls

last weekHealth / Aging : Fight Aging

Precision targeting makes all medicine better: delivering smaller total doses to precise locations in the body opens many doors. Types of therapeutic compound that would otherwise be impractical to use become practical. Localized dosage levels that would otherwise be impossible can be obtained. Show More Summary

Targeting Cholesterol Homeostasis in Hearing Loss

last weekHealth / Aging : Fight Aging

This open access paper presents an interesting view on age-related hearing loss, a contrast to more frequently reported efforts to regenerate hair cells in the ear known to be lost in old age: Hearing loss constitutes a major health problem affecting 16% of the adult population worldwide. Show More Summary

Arterial Stiffness, Elevated Blood Pressure, and Aging

last weekHealth / Aging : Fight Aging

Like skin, the walls of blood vessels lose their elasticity over the course of aging. Mechanisms involved in this loss include rising levels of long-lived cross-links in the extracellular matrix, wherein metabolic byproducts such as glucosepane glue together proteins and so alter the structural properties of important tissues. Show More Summary

Inhibiting Oligomer Formation in Alzheimer's Disease

last weekHealth / Aging : Fight Aging

The molecular biology of Alzheimer's disease is enormously complex, and efforts to better understand it have spurred a great deal of the broader work that has taken place to decipher and catalog the biology of the brain over the past twenty years. Show More Summary

Silica Nanoparticles Partially Reverse Osteoporosis in Mice

last weekHealth / Aging : Fight Aging

At the small scale, bone structure is constantly remodeled throughout life. We lose bone mass and strength as we age, a condition known as osteoporosis, in part due to a systemic shift of the balance of activities between osteoclasts that remove bone structure and osteoblasts that create it. Show More Summary

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