Blog Profile / Fight Aging

Filed Under:Health / Aging
Posts on Regator:5402
Posts / Week:10.8
Archived Since:April 26, 2008

Blog Post Archive

James Peyer at TEDxStuttgart: Can We Defeat the Diseases of Aging?

11 hours agoHealth / Aging : Fight Aging

My attention was drawn today to a recently published presentation by James Peyer. He heads up Apollo Ventures, one of the new crop of investment concerns focused on funding companies that are developing means to treat aging. These include...Show More Summary

Spurring Blood Vessel Growth via Signaling is Not as Simple as Hoped

20 hours agoHealth / Aging : Fight Aging

One of the strategies under development to tackle age-related ischemia, in which blood flow to a limb becomes insufficient due to vascular damage or dysfunction, is to attempt to use signaling mechanisms to spur the development of new blood vessels that bypass the damaged area. Show More Summary

More Evidence Against a Late Life Mortality Plateau

20 hours agoHealth / Aging : Fight Aging

It has been suggested that in very late life mortality rates flatten out and cease to increase. This effect has been observed in flies and other short-lived species, and insofar as aging is defined as an increase in mortality rate over time, it implies that old individuals cease to age. Show More Summary

Recent Insight into the Processes of Rejuvenation that Act to Ensure the Offspring of Adult Parents are Born Young

yesterdayHealth / Aging : Fight Aging

Parents and their germline cells are biologically old, and yet developing offspring produced from the germline are biologically young. Therefore a form of cellular rejuvenation takes place somewhere between the start and the end of reproduction...Show More Summary

Considering Age-Related Changes in Molecules in the Bloodstream in the Context of Cell Therapies for the Old

yesterdayHealth / Aging : Fight Aging

Parabiosis studies in which the circulatory systems of an old mouse and a young mouse are linked, and in which the old mouse shows a reversal of some measures of aging, have given rise to a broadening exploration of age-related changes in the molecules carried in the bloodstream. Show More Summary

More Evidence for Even Modest Levels of Physical Activity to be Beneficial

yesterdayHealth / Aging : Fight Aging

Quite a few studies on physical activity and mortality rate have been published in the past few weeks. They lean towards supporting the hypothesis that low levels of activity are still beneficial to some degree in older individuals.Show More Summary

The Most Obvious Tau Aggregates in Tauopathies, the Neurofibrillary Tangles, are not the Primary Cause of Harm

2 days agoHealth / Aging : Fight Aging

Altered proteins build up in the aging brain, forming solid deposits. The most prominent of them are amyloid-?, altered forms of tau, and ?-synuclein, giving rise to amyloidosis, tauopathies, and synucleinopathies respectively. Some conditions mix and match: Alzheimer's disease is both an amyloidosis and a tauopathy. Show More Summary

Recent Research Implicates Astrocytes in the Progression of Alzheimer's Disease

2 days agoHealth / Aging : Fight Aging

Astrocytes are one of a number of different classes of supporting cells of the brain, and researchers here investigate how they might be involved in the progression of Alzheimer's disease - though with the caution they they are looking at early-onset Alzheimer's linked to specific mutations. Show More Summary

Failing Mitochondria and Cellular Senescence in the Aging Lung

2 days agoHealth / Aging : Fight Aging

Mitochondrial dysfunction and cellular senescence are two of the root causes of aging targeted by the SENS rejuvenation research programs. They overlap at least a little, in that one might cause the other, but it is unclear as to whether this is significant for the specific types of mitochondrial damage considered important in the SENS view of aging. Show More Summary

Are Low Levels of Physical Activity Significant in Health and Longevity?

3 days agoHealth / Aging : Fight Aging

Mapping the dose-response curve for exercise, its effects on health and life expectancy, is of great interest to the research community. Given the significant time and effort required to make progress via epidemiological studies, this mapping will no doubt still be an ongoing concern even after the first rejuvenation therapies are widely available. Show More Summary

Bisphosphonates May Act to Reduce Mortality through Vascular Mechanisms

3 days agoHealth / Aging : Fight Aging

Bisphosphonates are used as a treatment for osteoporosis. Like most pharmaceutical therapies for age-related disease, they have a set of unpleasant side-effects, but a couple of studies have found evidence for long-term bisphosphonate use to reduce mortality in older individuals. Show More Summary

To What Extent are Gut Bacteria Involved in the Benefits of Fasting?

3 days agoHealth / Aging : Fight Aging

Calorie restriction improves health and extends life in most species and lineages tested, while both Protein restriction and intermittent fasting can provide similar but usually lesser packages of benefits. Once delving into the details of the biochemistry involved, however, the picture becomes very complex, and is still quite uncertain. Show More Summary

Fight Aging! Newsletter, November 20th 2017

4 days agoHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

Defenestration and the Roots of Age-Related Insulin Resistance

6 days agoHealth / Aging : Fight Aging

Defenestration is apparently a word with two meanings. The second, a scientific term, is the removal or loss of fenestrations. Let it never be said that this is not a place of learning. What, one might ask, are fenestrations? This is...Show More Summary

Towards Better Artificial Alternatives to Cartilage Tissue

6 days agoHealth / Aging : Fight Aging

It will be interesting to watch the accelerating development of biological versus non-biological replacements for damaged tissue over the next few decades. Both are improving at a fair pace, and there is a sizable area of overlap between the two sides of the field. Show More Summary

Stem Cell Therapy Partially, Unreliably Repairs Spinal Cord Injuries in Rats

6 days agoHealth / Aging : Fight Aging

Engineering regeneration of an injured spinal cord is one of the fields to watch as a marker of capabilities in stem cell medicine. There is a fair amount of funding and effort directed towards this goal, and it requires overcoming a number of issues that are relevant to other types of regenerative medicine. Show More Summary

Mild Mitochondrial Stress Found to Prevent Some of the Age-Related Declines in Cellular Maintenance in Nematodes

6 days agoHealth / Aging : Fight Aging

Hormesis is a near ubiquitous phenomenon in living organisms and their component parts: a little damage, a short or mild exposure to damaging circumstances, can result in a net benefit to health and longevity. Cells respond to damage...Show More Summary

The Results of Most Potential Biomarkers of Aging Vary Considerably

6 days agoHealth / Aging : Fight Aging

As expected, a study finds that the numerous candidate biomarkers of aging vary widely in their assessments of biological age. This makes complete sense, as (a) aging is caused by a number of distinct processes of damage accumulation,...Show More Summary

A Profile of James Clement's Supercentenarian Research

last weekHealth / Aging : Fight Aging

Should James Clement's name remain well-known in association any of the present day work on human longevity, one would hope it will be as one of the pioneers to first organize trials of senolytic therapies in humans, via his Betterhumans organization. Show More Summary

Human PAI-1 Loss of Function Mutants Found to Live Seven Years Longer than Peers

last weekHealth / Aging : Fight Aging

Researchers have found a noteworthy effect on longevity in a small study population that includes the only known individuals with a loss of function mutation in plasminogen activator inhibitor-1 (PAI-1). Individuals with the mutation live seven years longer on average than near relatives without it. Show More Summary

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