Blog Profile / Fight Aging


URL :http://www.fightaging.org
Filed Under:Health / Aging
Posts on Regator:5259
Posts / Week:10.7
Archived Since:April 26, 2008

Blog Post Archive

RIPK1 as a Target to Reduce Microglial Dysfunction in Alzheimer's Disease

5 days agoHealth / Aging : Fight Aging

One component of most neurodegenerative diseases is that classes of immune cells resident in the brain adopt disruptive, inflammatory behaviors. This is a reaction in some way to growing levels of damage in the form of aggregated proteins, such as amyloid-? and tau in Alzheimer's disease, but it isn't a helpful reaction. Show More Summary

Encapsulated Stem Cells Improve Heart Regeneration

5 days agoHealth / Aging : Fight Aging

Researchers here report on a cheaper implementation of encapsulation for transplanted stem cells, preventing the recipient's immune system from attacking cells originating from a different individual or even different species. SinceShow More Summary

An Introduction to DAF-16 and FOXO in the Context of Aging and Longevity

5 days agoHealth / Aging : Fight Aging

In the early 1990s Cynthia Kenyon and others produced the first C. elegans nematode worms to exhibit significantly extended longevity through a single gene mutation, in daf-2, the nematode version of the insulin-like growth factor 1 (IGF-1) receptor, and went on to map the relevant nearby biochemical landscape of these mutants. Show More Summary

Aiming to Develop Monoclonal Antibodies for Glucosepane

6 days agoHealth / Aging : Fight Aging

Funded by the SENS Research Foundation and allied philanthropists, the researchers at the Spiegel Lab are working on the tools needed to build the means to remove glucosepane cross-links from aged tissue. Like clearance of senescentShow More Summary

Is Dementia Incidence in Decline?

6 days agoHealth / Aging : Fight Aging

When the population as a whole is aging because of historical changes in birth and mortality rates, meaning that an increasing percentage of people are older rather than younger with each passing year, it is perfectly possible to observe...Show More Summary

HSP90 Inhibitors as Another New Class of Potential Senolytic Drug Compounds

6 days agoHealth / Aging : Fight Aging

The increasing number of senescent cells present in older tissues is one of the root causes of degenerative aging. It is also the closest to being effectively reversed. An open access paper describing the evidence for HSP90 inibitors to selectively destroy senescent cells was published earlier this month. Show More Summary

Reviewing the Effects of Exercise on Mitophagy and Mitochondrial Function

last weekHealth / Aging : Fight Aging

Mitochondrial damage is important in aging, and many of the means shown to modestly slow aging in various species involve increased cellular maintenance activities directed towards mitochondria. One of these is mitophagy, a specialized form of autophagy that recycles damaged mitochondria. Show More Summary

The First Practical Means of Human Rejuvenation are Not Distant

last weekHealth / Aging : Fight Aging

The first, narrowly focused rejuvenation therapies based on repair of the cell and tissue damage that causes aging already exist. They are entering trials, they are under development in companies. Senolytic therapies to clear senescent...Show More Summary

Fight Aging! Newsletter, September 18th 2017

last weekHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

Cellular Biochemistry is Never Simple: an Example Involving Autophagy and Aging

last weekHealth / Aging : Fight Aging

Nothing in cellular biology is any way straightforward. All rules have exceptions, enormous complexity is the norm, and old understandings are consistently overturned with the arrival of new data: what was thought to be simple turns out to be anything but simple. Show More Summary

Can the Age-Related Harm Done by Fat Tissue be Prevented?

last weekHealth / Aging : Fight Aging

The way to avoid the harms done to long-term health and life expectancy by excess visceral fat tissue is not to gain that fat, or to lose it if you have it. This is not the path pursued by that part of the research community interested following the large-scale funding associated with the metabolic diseases of obesity, of course. Show More Summary

Protein Posttranslational Modifications in Aging

last weekHealth / Aging : Fight Aging

This very readable review paper walks through what is known of modifications to proteins that occur after their creation, and the role these modifications play in aging. If you are familiar with the SENS view of aging as an accumulation...Show More Summary

Senescent Cells May Disrupt Platelet Regulation while Generating Chronic Inflammation

last weekHealth / Aging : Fight Aging

If you spend much time scanning through papers of interest to the field of aging research, one of the things that may strike you about the past few years of work on senescent cells is the way in which it dovetails so well with past research of all sorts. Show More Summary

Support for the "Bad Old Blood" rather than "Good Young Blood" View of what is Taking Place in Heterochronic Parabiosis

last weekHealth / Aging : Fight Aging

Join the circulatory systems of two mice, one young and one old, a procedure known as heterochronic parabiosis, and the young one suffers some of the impact of aging while the old one loses some of that same impact. Regenerative capacity and stem cell activity are affected, for example. Show More Summary

Calorie Restriction Slows Epigenetic Changes Associated with Aging

last weekHealth / Aging : Fight Aging

The results noted here are unsurprising, a confirmation of what was expected by most in the field. The practice of calorie restriction has been shown to extend healthy life span and slow near all measures of aging in a range of species. Show More Summary

Artificially Reduced LDL Cholesterol Levels Far Lower than those of Healthy, Young Individuals Appear to be Beneficial

last weekHealth / Aging : Fight Aging

Therapies such as statins, that aim to reduce circulating levels of low-density lipoprotein (LDL) cholesterol, are perhaps the most prevalent medical approach to cardiovascular disease. Indeed, when measured against the low bar set for past attempts to treat age-related conditions, they are one of the most successful forms of treatment to date. Show More Summary

How Reversible is the Cellular Dysfunction Related to Amyloid-??

last weekHealth / Aging : Fight Aging

This is an interesting experiment, though note that the DOI link goes straight to a PDF at the time of writing. It is carried out in cell culture, so don't take the results too seriously: they would have to be replicated in at least an organoid tissue structure that better matched natural brain tissue. Show More Summary

Yes, Type 2 Diabetes is Reversible, as Soon as the Patient Chooses To Eat Less

last weekHealth / Aging : Fight Aging

The evidence has been in place for some years to show that low calorie diets can reverse type 2 diabetes even in comparatively late stages. For the vast majority of patients, this is a disease of choice: they chose to become fat enough...Show More Summary

Another Study Assessing the Impact of Sitting on Life Expectancy

last weekHealth / Aging : Fight Aging

In the past few years, a number of epidemiological studies have suggested a correlation between more time spent sitting and a greater risk of mortality and age-related disease. Intriguingly, the claim is that this correlation persists even in people who do in fact exercise sufficiently. Show More Summary

Quantifying the Impact of Air Pollution on Life Expectancy

last weekHealth / Aging : Fight Aging

Areas of China can act as a laboratory for the impact of particulate air pollution on long-term health. There are good reasons to think that the established correlations between air pollution and life expectancy are due to physical and biochemical mechanisms such as increased chronic inflammation. Show More Summary

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