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Blog Profile / Fight Aging


URL :http://www.fightaging.org
Filed Under:Health / Aging
Posts on Regator:3995
Posts / Week:11.5
Archived Since:April 26, 2008

Blog Post Archive

There is Still Not Enough Use of Research Prizes in Medicine

yesterdayHealth / Aging : Fight Aging

Establishing a research prize is a form of investment in progress only available in the philanthropic world. At the very high level it is easy to say that philanthropists pay people to work on specific tasks. This is simple enough for...Show More Summary

Mitochondrial DNA Damage in Atherosclerosis

2 days agoHealth / Aging : Fight Aging

Mitochondria, the power plants of the cell, have their own small genomes left over from their ancient origins as symbiotic bacteria. This mitochondrial DNA (mtDNA) becomes damaged in ways that evade cellular quality control mechanisms as a consequence of the normal operation of metabolism. Show More Summary

Are Advanced Glycation End-Products Protective as Well as Harmful?

2 days agoHealth / Aging : Fight Aging

Some of the important processes in aging are known to be initially protective at lower levels and later harmful. Senescent cell accumulation is a good example, as it acts to suppress cancer incidence by permanently removing the most at risk cells from the cell cycle. Show More Summary

Meeting in the Middle Between Aging as a Genetic Program and Aging as Accumulated Damage

2 days agoHealth / Aging : Fight Aging

As noted in a prior post, a great deal of theorizing on aging takes place in the research community. We should expect this as the natural outcome of the study of a very complex and still only partially understood system, which is toShow More Summary

Falling Mitochondrial DNA Copy Number in Type 2 Diabetes

3 days agoHealth / Aging : Fight Aging

A herd of bacteria-like mitochondria exist in every cell in the body, constantly dividing, fusing, and swapping component parts among one another, as well as being destroyed when damaged by cellular quality control mechanisms. Mitochondria...Show More Summary

Towards a Signature of Age in Blood Plasma

3 days agoHealth / Aging : Fight Aging

Various tools are presently under development as means to measure age from tissue samples, such as by looking at DNA methylation patterns. A marker for biological age is very much needed in order to speed up development of treatments...Show More Summary

A Malfunction of Homeostatic Control Theory of Aging

3 days agoHealth / Aging : Fight Aging

There are many theories of aging, and we should expect more of them arise in the years ahead. On the one hand there is a growing interest in the science of aging as a place where careers can be made and on the other hand there is a great...Show More Summary

Hair Regrowth as a Pointer to the Role of Immune System Activity in Tissue Regeneration

4 days agoHealth / Aging : Fight Aging

The immune system is known to play an important role in regeneration, but the details are still being uncovered. Nonetheless at some point in the near future manipulation of immune cells may prove to be a viable alternative path in regenerative...Show More Summary

A Role for Hydrogen Sulfide in Calorie Restriction

4 days agoHealth / Aging : Fight Aging

A great deal of effort over the past fifteen years has gone into efforts to fully understand how calorie restriction works to improve health and extend life. The research community would like to have sufficient knowledge to produce drugs that mimic this effect. Show More Summary

Considering Microbial Contributions to the Evolution of Aging

4 days agoHealth / Aging : Fight Aging

Two more or less opposing ways to think about the evolution of aging are as follows (a) aging is actively selected for because it provides some benefit to species survival, such as increased adaptability to environmental change, or (b)...Show More Summary

Cellular Senescence is Complicated

5 days agoHealth / Aging : Fight Aging

Cellular senescence is a process that serves to reduce cancer risk by removing damaged cells from the cell cycle and irreversibly suppressing their ability to proliferate. Unfortunately it is also one of the root causes of degenerative...Show More Summary

Updates on the Biodemography of Aging and Longevity

5 days agoHealth / Aging : Fight Aging

This is a review of published research in the biodemography of aging produced by one particular group over the past few years. A lot of their work sits within the framework of reliability theory, which is a fairly high-level but useful model of damage and failure in complex systems. Show More Summary

Investigation of a Role for Progerin in Normal Aging

5 days agoHealth / Aging : Fight Aging

Progerin is a malformed variant of lamin A, a protein vital in the nuclear lamina. These are structures that provide mechanical support for the cell, but are also involved in a variety of fundamental and important processes in the cell cycle. Show More Summary

A Review of the Endocrinology of Aging

6 days agoHealth / Aging : Fight Aging

Here is an open access review of what is known of changes in the endocrine system that occur with aging. This is many steps removed from the low-level cellular and molecular damage that causes degenerative aging. It is a good example...Show More Summary

Preliminary Evidence Suggesting Long Term Memory is Not Stored in Synapses

6 days agoHealth / Aging : Fight Aging

Long-term memory is thought to exist as structures within synapses, which is why the destruction of synapses in the earlier stages of neurodegenerative conditions such as Alzheimer's disease causes memory loss. If memory doesn't exist...Show More Summary

Preparation is Vital for a Good Cryopreservation

last weekHealth / Aging : Fight Aging

The cryonics industry provides the only alternative to the grave for people who will age to death prior to the advent of rejuvenation treatments. Sadly, even after four decades of service this remains a small industry and only a tiny...Show More Summary

Why do Some Muscles Show Fewer Signs of Aging?

last weekHealth / Aging : Fight Aging

Not all muscles in the body age equally, it seems, and those surrounding the eye are spared many of the degenerative changes that occur elsewhere. Investigating why this is the case may help to inform other lines of research that aim...Show More Summary

Sensory and Neuronal Influences on Fly Longevity

last weekHealth / Aging : Fight Aging

Life spans in short-lived animals can be made to vary far more in response to circumstances than the life spans of longer-lived animals. In the case of calorie restriction there is an evolutionary explanation in that if periods of famine...Show More Summary

"So Does Ibuprofen"

last weekHealth / Aging : Fight Aging

Every few years a new hot thing emerges in the field of drug candidates to slow aging. It was sirtuins for a while and then rapamycin and there will be others in due course. This happens because it is very possible to raise funding,Show More Summary

Theorizing on Interactions Between Telomeres and the DNA Damage Response in Cellular Senescence

last weekHealth / Aging : Fight Aging

Cells can enter a senescent state in response to damage, ceasing to divide. This reduces the risk of cancer under most circumstances, but is also a part of the wound healing process. This isn't all good, however. Senescent cells secrete...Show More Summary

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