Blog Profile / Fight Aging

Filed Under:Health / Aging
Posts on Regator:4096
Posts / Week:9.8
Archived Since:April 26, 2008

Blog Post Archive

SERCA2a Gene Therapy to Treat Pulmonary Hypertension

8 hours agoHealth / Aging : Fight Aging

A gene therapy study carried out in pigs has demonstrated promising results for the treatment of pulmonary arterial hypertension, the form of pulmonary hypertension that involves narrowing of the blood vessels in the lungs. The therapy overexpresses SERCA2a, an approach already under development for the treatment of heart failure. Show More Summary

A Recent Study of Nicotinamide Riboside Supplementation

8 hours agoHealth / Aging : Fight Aging

Here I'll point out a recent study on nicotinamide riboside supplementation in mice. This is a way to increase levels of nicotinamide adenine dinucleotide (NAD), an important player in many aspects of cellular metabolism, particularly mitochondrial function and everything associated with it. Show More Summary

A Brace of Articles on Cryonics

18 hours agoHealth / Aging : Fight Aging

I can only speculate as to why a set of better than usual articles on the non-profit cryonics industry have appeared in various popular press publications recently. I pointed out one of them yesterday, and here I'll offer links to another two. Show More Summary

Thermoregulation in Aging and Alzheimer's Disease

yesterdayHealth / Aging : Fight Aging

Researchers have provided initial and somewhat speculative data to suggest that the decrease in body temperature that occurs in old age may speed the progression of mechanisms implicated in Alzheimer's disease: "We know that the incidence of Alzheimer's is low before age 65, but doubles every 5 to 6 years afterward. Show More Summary

The Latest Results from a Trial of Chimeric Antigen Receptor Immunotherapy to Treat Cancer

yesterdayHealth / Aging : Fight Aging

Immunotherapies will clearly make up a large fraction of the coming generation of targeted cancer therapies, but the state of progress is very uneven at this stage, and therapies will still be specific to types and subtypes of cancer - the primary reason why cancer research is so expensive and slow. Show More Summary

Opponents of Longevity Science Should be Encouraged to Think Critically About How Exactly They Want to Die

yesterdayHealth / Aging : Fight Aging

If you survey people on the topic of developing new medical technologies to enable longer lives, you'll find what looks like widespread opposition to the idea. We are a very conformist species, and in an environment in which everyone...Show More Summary

Chronic Inflammation Harms Hematopoietic Stem Cells

2 days agoHealth / Aging : Fight Aging

Hematopoietic stem cells reside in bone marrow and are responsible for producing blood cells, including immune cells. Recent research illustrates one way in which chronic inflammation, important in the progression of degenerative aging, can harm this stem cell population. Show More Summary

Another Example of Cryonics in the Popular Press

2 days agoHealth / Aging : Fight Aging

Here is a recent example of the more respectful treatment the cryonics industry receives in the popular press these days, though, as ever, the very important differences between freezing and vitrification in terms of their effects on tissues are skipped over. Show More Summary

It Looks Like UNITY Biotechnology is Taking the Drug Development Path to Senescent Cell Clearance

2 days agoHealth / Aging : Fight Aging

UNITY Biotechnology and Oisin Biotechnologies are both early stage startups working on commercial development of therapies capable of clearance of senescent cells. Since accumulation of senescent cells is one of the root causes of aging and age-related disease, periodic removal of these cells is a narrowly focused form of rejuvenation. Show More Summary

If Nothing is Done, Sarcopenia Incidence Will Increase Greatly

2 days agoHealth / Aging : Fight Aging

Researchers here predict future incidence of sarcopenia, the loss of muscle mass and strength that occurs with aging and that is one of the main components of age-related frailty. As the average age of a population rises, incidence,Show More Summary

Evidence for Cross-Linking to Impair Muscle Stem Cells

3 days agoHealth / Aging : Fight Aging

Researchers here provide a little evidence to suggest that increasing stiffness in muscle extracellular matrix, caused in part by growth in the level of persistent cross-links, explains some of the age-related decline in stem cell activity in that tissue. Show More Summary

The Scientist on BioViva's Initial Test of Human Gene Therapies

3 days agoHealth / Aging : Fight Aging

The Scientist has published a measured piece on the first results from BioViva's initial test of human gene therapy, telomerase and follistatin overexpression, and the broader context in which this single person test took place. TheShow More Summary

IL-33 Clears Amyloid and Reverses Symptoms in a Mouse Model of Alzheimer's Disease

4 days agoHealth / Aging : Fight Aging

Researchers here demonstrate a method of spurring microglia to attack amyloid in mice. It should be said that this is only the latest in a number of approaches shown to clear amyloid and improve symptoms in a mouse model of Alzheimer's disease. Show More Summary

The Revolution Against Aging and Death (RAAD) Festival

4 days agoHealth / Aging : Fight Aging

The Revolution Against Aging and Death (RAAD) Festival will be held in California this coming August. The list of speakers is a fascinating combination of the old and the new in the life extension advocacy community: people who haveShow More Summary

Fight Aging! Newsletter, April 25th 2016

5 days agoHealth / Aging : Fight Aging

FIGHT AGING! NEWSLETTER April 25th 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent...Show More Summary

The Small Molecule View: Searching for Drugs to Slow Aging

6 days agoHealth / Aging : Fight Aging

Today I thought I'd point out a couple of interesting papers on the work of finding drugs to intervene in the aging process. This is far from a widespread undertaking, even now that more funding is arriving into the field. The majority...Show More Summary

Arguing for Cryonics Providers to Integrate with the Funerary Industry to Spur Growth

6 days agoHealth / Aging : Fight Aging

Cryonics is the low-temperature vitrified storage of at least the brain on clinical death, with good evidence for it to preserve the fine structures that store the data of the mind. For so long as the mind is maintained, there is a chance that future technologies and societies will become capable of restoration. Show More Summary

BioViva Claims Success in Initial Human Telomerase Gene Therapy

last weekHealth / Aging : Fight Aging

Initial data appears to show success for the telomerase gene therapy undergone by the BioViva CEO last year. Similar gene therapies extend life in mice, most likely though increased stem cell activity and thus improved tissue maintenance. Show More Summary

Larger Sources of Funding for Longevity Science are Slowly Awakening

last weekHealth / Aging : Fight Aging

Today's news, linked below, comes from the Russian end of the longevity science community. If you've been following the work of the Science for Life Extension Foundation folk over the years, then you'll recognize many of the names involved, but this particular announcement involves a group that I wasn't aware existed. Show More Summary

Considering the Treatment of Oxidative Stress and Fibrosis in Aging

last weekHealth / Aging : Fight Aging

The presence of reactive oxidizing molecules in our tissues increases with age. These cause damage by reacting with proteins, all of which are important parts of the biological machinery in some portion of a cell. An oxidized protein has a different chemical structure and thus cannot perform its normal tasks. Show More Summary

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