Blog Profile / Fight Aging

Filed Under:Health / Aging
Posts on Regator:5634
Posts / Week:10.9
Archived Since:April 26, 2008

Blog Post Archive

New Findings in the Biochemistry of Parkinson's Disease

last weekHealth / Aging : Fight Aging

Today I'll point out a couple of recently published research results that add to the understanding of Parkinson's disease and its progression. Parkinson's disease is comparatively straightforward as neurodegenerative diseases go - which...Show More Summary

Senolytic Drugs Fail to Kill Cancerous Cells with Senescent Gene Expression Signatures, but a Gene Therapy Succeeds

last weekHealth / Aging : Fight Aging

Some cancerous cells express signatures normally associated with senescent cells, so why not try senolytic compounds against them? This is something of a full circle, given that most of the current senolytic drug candidates were originally characterized and tested as potential chemotherapeutics. Show More Summary

ERR? as a Target for the Development of Exercise Mimetics

last weekHealth / Aging : Fight Aging

The research noted here is a representative example of efforts to reverse engineer the mechanisms by which exercise produces benefits, with an eye to achieving the same result with pharmaceutical compounds rather than exertion. Exercise...Show More Summary

Undoing Aging: an Interview with Michael Greve of the Forever Healthy Foundation

last weekHealth / Aging : Fight Aging

The Undoing Aging conference is coming up later this month in Berlin, the latest in a long series of conferences focused initially on the science and later on commercial development of SENS rejuvenation biotechnology. In addition toShow More Summary

Greater Levels of Dbx2 Appear Connected to Neural Stem Cell Decline in Aging

last weekHealth / Aging : Fight Aging

Stem cells are responsible for tissue maintenance, delivering replacement somatic cells and a variety of signals that help to keep organs and other biological systems running. There are many varieties of stem cell, at least one for every tissue type, and all have significant differences in their biochemistry. Show More Summary

Funding More Work on Deep Learning for Drug Discovery to Treat Aging

last weekHealth / Aging : Fight Aging

Recently Y Combinator announced their intent to fund companies working on treatments for aging. It is one of the many signs of a growing interest in this area of development in the venture community. One of the early results appearsShow More Summary

How to Plan and Carry Out a Simple Self-Experiment, a Single Person Trial of Senolytic Peptide FOXO4-DRI

last weekHealth / Aging : Fight Aging

This lengthy post covers the topic of setting up and running a self-experiment, a human trial of a single individual, to assess the senolytic effects of the peptide FOXO4 D-Retro-Inverso (FOXO4-DRI). This is the protein produced from the FOXO4 gene, with D-amino acids substituted for L-amino acids, reversing the chirality of the molecule. Show More Summary

The Prospects for Enhancing Repair Systems in the Brain to Treat Stroke Patients

last weekHealth / Aging : Fight Aging

A sizable fraction of the regenerative medicine community is interested in finding ways to improve existing repair systems in the body, and particularly in the central nervous system, which exhibits little ability to recover from injury in mammals. Show More Summary

Loss of Ribosomal DNA is Associated with Aging in Flies

last weekHealth / Aging : Fight Aging

Researchers here make an interesting discovery in the genetics of fly aging. Old flies lose repeated DNA sequences in the genome that encode for RNA related to the ribosome, a cellular structure important in the intricate, multi-stage process by which proteins are created from their genetic blueprints. Show More Summary

Tetramethylpyrazine is Senolytic in Bone Marrow: Reduces Inflammation and Improves Stem Cell Function in Mice

last weekHealth / Aging : Fight Aging

Today's open access paper reports on a new senolytic drug candidate, with good-looking data on its effects on the bone marrow environment in aged mice - reducing inflammation, and improving the hematopoietic stem cell pool, among other benefits. Show More Summary

Can the Endosomal Network be Restored to Treat Neurodegenerative Conditions?

last weekHealth / Aging : Fight Aging

The endosomal network is a complex system of many parts responsible for moving endosomes within cells. Endosomes are membrane-bound packages used to transfer material in the cell to destinations such as lysosomes, where it is broken down, or a variety of other locations. Show More Summary

Four Genes, Combined, Can Unlock Replication in Heart Muscle Cells, Spurring Regeneration and Regrowth

last weekHealth / Aging : Fight Aging

The heart is not a very regenerative organ in mammals, its cells comparatively reluctant to multiply to make up losses or repair injuries - and mammals are a good deal less regenerative than many other species. Zebrafish can regenerate entire missing sections of the heart to completely restore normal function without scarring, for example. Show More Summary

A Three Part Discussion of Mitochondrial Hormesis as an Approach to Slow Aging

last weekHealth / Aging : Fight Aging

This three part interview covers the induction of greater numbers of free radicals in tissues as an approach to slow aging. I can't say as I think this is a way to obtain large gains in health and longevity, much greater than those possible through exercise and calorie restriction. Show More Summary

The Possibility of Telomerase Therapy without Adding More Telomerase

last weekHealth / Aging : Fight Aging

Telomerase gene therapy as a treatment for aging is a popular topic these days, given the results in mice from past years, though I still think that more work needs to be done in mammals other than mice to address concerns related to cancer risk and effectiveness. Show More Summary

A Small Molecule Inhibitor of Ice Crystal Formation Aids Cryopreservation

last weekHealth / Aging : Fight Aging

In cryopreservation of tissues, ice is the primary enemy. Ice crystals destroy cell structures, both during freezing, and again during thawing. Ice is the reason why a great deal of effort has gone into the development of cryoprotectant chemicals that enable vitrification, a low-temperature state with minimal ice formation. Show More Summary

There is no Obesity Paradox: Excess Weight is Harmful to Long Term Health

last weekHealth / Aging : Fight Aging

The research results here are from the latest in a line of epidemiological studies to firmly refute the obesity paradox, burying it with more data and better study design, to show that excess weight is very definitely harmful to health and longevity. Show More Summary

Genetic Editing of ANGPTL3 to Greatly Reduce Blood Cholesterol in Mice

last weekHealth / Aging : Fight Aging

There are a few genes in which rare variants have been noted to dramatically lower blood cholesterol and other lipids, thus significantly reducing the progression of atherosclerosis with age. ANGPTL4 is one of them, and based on the work here, so is ANGPTL3. Show More Summary

A Potential Oxidative Biomarker of Aging in Urine

last weekHealth / Aging : Fight Aging

Since aging is caused by a collection of distinct, interacting processes of damage accumulation and reactions to that damage, it is unlikely that there will ever exist one, unified, undisputed measure of biological age. All present candidate...Show More Summary

Reporting on an Attempted Study of One with Candidate Senolytic Pharmaceuticals

last weekHealth / Aging : Fight Aging

This post describes the results of an attempt to run a self-experiment using senolytic drug candidates derived from chemotherapeutics. Based on animal study data, these pharmaceuticals are potential means to selectively destroy some fraction of senescent cells in some tissues. Show More Summary

Companion Dogs as a Model for the Details of Human Aging

2 weeks agoHealth / Aging : Fight Aging

For research purposes, dogs are argued to be a good compromise between the very long life span of humans, meaning costly and lengthy studies that result in high quality data, and the very short lives of mice, meaning less expensive, shorter studies, but questions regarding the relevance of the data to human medicine. Show More Summary

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