Blog Profile / Fight Aging


URL :http://www.fightaging.org
Filed Under:Health / Aging
Posts on Regator:5123
Posts / Week:10.6
Archived Since:April 26, 2008

Blog Post Archive

Fight Aging! Newsletter, July 24th 2017

20 hours agoHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

Signs of the Spreading Interest in Cellular Senescence as a Cause of Aging

2 days agoHealth / Aging : Fight Aging

In just a few short years, the study of cellular senescence has grown enormously. It has become an area of intense interest and funding in comparison to its prior status as a thin sideline of cancer research and a yet another of the backwaters of aging research. Show More Summary

Assessing the Degree to Which Dementia is Self-Inflicted

2 days agoHealth / Aging : Fight Aging

Risk of neurodegenerative disease is strongly connected to the health of the cardiovascular system. Lack of exercise and putting on excess weight significantly increase the risk of both cardiovascular disease and forms of dementia. You...Show More Summary

Another Study Showing Centenarians to Suffer a Lesser Burden of Disease

2 days agoHealth / Aging : Fight Aging

In this research, it is shown that centenarians have a lower burden of disease than people who die at earlier ages. You might compare it with very similar results noted last month. Aging is the accumulation of molecular damage and its consequences; the only way to reach later ages is to be less damaged or more resilient to the consequences of damage. Show More Summary

Reducing Inflammation Assists Stem Cell Therapies to Enhance Regeneration

3 days agoHealth / Aging : Fight Aging

The immune system is highly influential in the processes of regeneration. Inflammation is a key marker of the types of immune cell involved and the sort of activities they are undertaking, either helping or hindering regeneration, and greater levels of inflammation are usually a bad thing. Show More Summary

Engineering Macrophages to Ignore "Don't Eat Me" Signals from Cancer Cells

3 days agoHealth / Aging : Fight Aging

Macrophages are one of the types of immune cell responsible for destroying potentially dangerous cells, such as those that have become cancerous. Unfortunately cancerous cells tend to circumvent the immune system by displaying molecules on their outer surface that cause macrophages to leave them alone. Show More Summary

Lifespan.io Crowdfunding Initiative for AgeMeter Development

3 days agoHealth / Aging : Fight Aging

The latest Lifespan.io crowdfunding campaign is in support of AgeMeter development, an infrastructure technology used to assemble the data needed for compound biomarkers of aging built from existing simple health measures. The development...Show More Summary

The Terrible State of Experimental Reproducibility in Much of Aging Research

4 days agoHealth / Aging : Fight Aging

Considering the whole of the past thirty years, it is fairly safe to say that studies showing improved longevity in animal models have a terrible track record when it comes to the reproduction of findings. Small gains in life expectancy in one study promptly evaporate when it is attempted by other groups. Show More Summary

A Possible Path to Preventing TDP-43 Aggregation

4 days agoHealth / Aging : Fight Aging

TDP-43 is known to increase with age, and also forms aggregates observed in ALS and frontemporal dementia, among other conditions. The increased amount of TDP-43 alone, even without aggregates, appears to diminish the cellular housekeeping process of autophagy, with detrimental long term consequences. Show More Summary

FOXO3 Less Influential on Aging than Thought

4 days agoHealth / Aging : Fight Aging

Despite an enormous amount of effort, researchers have discovered very few human gene variants with reliable effects on longevity across multiple study populations, and even those effects are small. FOXO3 is one of these genes. The current...Show More Summary

Recent Considerations of the Battle Between Exercise and Sarcopenia

5 days agoHealth / Aging : Fight Aging

Today, I'll point out a few recent papers relevant to the decline of muscle mass and strength that takes place with aging. The research community is somewhere in the midst of the long process of formally defining this process as a disease called sarcopenia. Show More Summary

Alternative Splicing in Aging and Cellular Senescence

5 days agoHealth / Aging : Fight Aging

This open access review looks over present opinions on whether or not alternative splicing is important in aging, and in the creation and harmful activities of senescent cells in particular. Alternative splicing refers to the fact that a single gene can code for different proteins. Show More Summary

Fewer Translation Errors Correlates with Greater Species Longevity in Rodents

5 days agoHealth / Aging : Fight Aging

Here, researchers provide evidence for a correlation between the rate of errors in translation, a step in the process by which proteins are produced from their genetic blueprints, and species longevity. Infrequent errors in the creation...Show More Summary

An Interview with Aubrey de Grey of the SENS Research Foundation

6 days agoHealth / Aging : Fight Aging

Aubrey de Grey, advocate for radical life extension and originator of the Strategies for Engineered Negligible Senescence (SENS) research programs, has derived a great deal of mileage from his assessment that it is possible to achieve life spans of 1000 years or longer, as illustrated in the brief interview below. Show More Summary

The Variability of Senescent Cells

6 days agoHealth / Aging : Fight Aging

Prior to a few years ago, senescent cells were a research backwater, and this state of affairs persisted for far too long given the evidence for their importance in degenerative aging. As a result, the standard assays for the presence of cellular senescence are going on twenty years old, an eternity in biotechnology development. Show More Summary

More Evidence for the Immune System to be Important in Exceptional Regeneration

6 days agoHealth / Aging : Fight Aging

It is becoming clear that the behavior of varieties of macrophage immune cells (including the microglia resident in the central nervous system) is important in regeneration, and may be one of the key distinguishing differences between...Show More Summary

Fight Aging! Newsletter, July 17th 2017

last weekHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

Recent Epidemiological Research Relevant to the Understanding of Aging

last weekHealth / Aging : Fight Aging

Today, I thought I'd point out a few varied publications from the epidemiology research community. They have nothing much in common beyond being interesting and of relevance to the broader understanding of how aging progresses at the present time. Show More Summary

ADAM17 and Caveolin-1 in Cardiac Syndrome X

last weekHealth / Aging : Fight Aging

Cardiac syndrome X has the standard risk factors for cardiovascular disease, which is to say age of the individual and degree of excess fat tissue carried by the individual. It is a comparatively poorly understood variety of structural alteration and failure of blood vessels, however. Show More Summary

Reduced Insulin Modestly Extends Life in Mice

last weekHealth / Aging : Fight Aging

Researchers here demonstrate that reducing the levels of circulating insulin in mice extends life by 10% or so in the best scenario they tested. Insulin, insulin-like growth factor 1 (IGF-1), and growth hormone are all closely linked...Show More Summary

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