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Blog Profile / In the Pipeline


URL :http://pipeline.corante.com/
Filed Under:Medical / Pharmaceutical
Posts on Regator:1913
Posts / Week:9.2
Archived Since:November 3, 2010

Blog Post Archive

Francis Collins Knows Why We Don't Have An Ebola Vaccine

NIH Director Francis Collins has been saying that if only the agency's budget hadn't been cut, that we would already have an Ebola vaccine. He tried this line out during recent Congressional testimony, and apparently liked it enough that he expanded on it in an article for the Huffington Post. Show More Summary

Not The Sort Of Thing You'd Work With, Given a Choice

Here's a paper that illustrates a different way of looking at the world than many medicinal chemists would have. It discusses inhibitors of SETD8, an unusual epigenetic enzyme that is the only known methyltransferase to target lysine 20 of histone H4. Show More Summary

Atmospheric Conditions

Well, I've been busy sciencing away all morning, and we're having the kind of weather outside that makes a person want to stay indoors and do chemistry: rainy, chilly, and windy. You wonder why more big chemical discoveries don't come...Show More Summary

Green Coffee Beans Will Mostly Slim Your Wallet

Very few readers of this site are likely to have a good opinion of Dr. Oz (I certainly don't). And very few readers will be surprised to hear that one of his highly-touted miracle weight loss regiments - green coffee bean extract (GCA) - has turned out to be a load of faked-up nonsense. Show More Summary

Roche Rebuilds

Roche has announced ambitious plans for new buildings at its home base in Basel: They're building a new home for John Reed and Roche's pRED research group in Basel – and the pharma giant is thinking big. Roche said today that it is committing...Show More Summary

Improving the Old-Fashioned Reaction Workup

Here's something new: working up a reaction. The authors say that they have a porous polymer that adsorbs organic compounds from aqueous reaction mixtures, allowing you to just stir and filter rather than doing a liquid/liquid extraction. Show More Summary

Phenylalanine Crystals

No matter how long you've been doing chemistry, there are still things that you come across that surprise you. Did you know that plain old L-phenylalanine has been one of the most difficult subjects ever for small-molecule crystallography? I sure didn't. Show More Summary

Oxygenated Nanobubbles. For Real?

A longtime reader sent along this article, just based on the headline. "This headline triggers instant skepticism in me", he said, and I agree. "Potential to treat Alzheimer's" is both a bold and a weaselly statement to make. The weasel...Show More Summary

Compound Properties: Starting a Renunciation

I've been thinking a lot recently about compound properties, and what we use them for. My own opinions on this subject have been changing over the years, and I'm interested to see if I have any company on this. First off, why do we measure...Show More Summary

More on "Metabolite Likeness" as a Predictor

A recent computational paper that suggested that similarity to known metabolites could help predict successful drug candidates brought in a lot of comments around here. Now the folks at Cambridge MedChem Consulting have another lookShow More Summary

Different Screening, Different Thermodynamics?

Chris Lipinski and the folks at Collaborative Drug Discovery send word of an interesting webinar that will take place this coming Wednesday (October 22nd) at 2 PM EST. It's on enthalpic and entropic trends in ligand binding, and howShow More Summary

The Electromagnetic Field Stem Cell Authors Respond

The authors of the ACS Nano paper on using electromagnetic fields to produce stem cells have responded on PubPeer. They have a good deal to say on the issues around the images in their paper (see the link), and I don't think that argument is over yet. Show More Summary

What's The Going Rate These Days?

Time to break out the pseudonyms for the comments section. I've had a couple of people asking (on both sides of the process) what the starting salaries for medicinal chemists are running in the Boston/Cambridge area. It's been a while...Show More Summary

No More Varian

This week has brought news that Agilent is getting out of the NMR business, which brings an end to the Varian line of machines, one of the oldest in the business. (Agilent bought Varian in 2010). The first NMR I ever used was a Varian EM-360, which was the workhorse teaching instrument back then. Show More Summary

Combichem Into Drugs: How Many?

So here's a question I got from a reader the other day, that I thought I'd put up on the site. How many drugs have there been whose origins were in combichem? I realize that this could be tricky to answer, because compound origins are sometimes forgotten or mysterious. But did the combichem boom of the 1990s produce any individual compound success stories?

Electromagnetic Production of Stem Cells? Really?

Now this is an odd paper: its subject matter is unusual, where it's published is unusual, and it's also unusual that no one seems to have noticed it. I hadn't, either. A reader sent it along to me: "Electromagnetic Fields Mediate Efficient...Show More Summary

Alzheimer's in Cell Culture?

While we're talking about cell culture, there's some potentially significant news in Alzheimer's. The Tanzi lab at Mass General is reporting in Nature that they've been able to grow 3D neuronal cultures that actually reproduce the plaque-and-tangle symptoms of Alzheimer's. Show More Summary

Diabetes Progress

There have recently been some welcome developments in diabetes therapy, both Type I and Type II. For the latter, there's an interesting report of a metabolic uncoupling therapy in Nature Medicine. Weirdly, it uses a known tapeworm medication, niclosamide (specifically, the ethanolamine salt). Show More Summary

More on Fluorescent Microscopy Chemistry Prizes

I wanted to note (with surprise!) that one of this year's Nobel laureates actually showed up in the comments section of the post I wrote about him. You'd think his schedule would be busier at the moment (!), but here's what he had to say: A friend pointed this site/thread out to me. Show More Summary

You'd Think That This Can't Be Correct

Well, here's something to think about over the weekend. I last wrote here in 2011 about the "E-cat", a supposed alternative energy source being touted/developed by Italian inventor Andrea Rossi. Odd and not all that plausible claimsShow More Summary

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