Blog Profile / Nature AOP

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Archived Since:August 26, 2016

Blog Post Archive

Patchy particles made by colloidal fusion

Patches on the surfaces of colloidal particles provide directional information that enables the self-assembly of the particles into higher-order structures. Although computational tools can make quantitative predictions and can generate...Show More Summary

Neuroscience: Mum's bacteria linked to baby's behaviour

Infection during pregnancy increases the risk of neurodevelopmental disorders, such as autism, in offspring. Mouse studies now reveal a link between gut bacteria and atypical brain-circuit connections.

Rabies screen reveals GPe control of cocaine-triggered plasticity

A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.

Reversing behavioural abnormalities in mice exposed to maternal inflammation

The authors define a specific cortical subregion of the somatosensory cortex as a critical region of dysfunction that is causal to the emergence of abnormal social and repetitive behaviours in mice exposed to maternal inflammation.

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders

Cytosolic DNA arising from intracellular pathogens triggers a powerful innate immune response. It is sensed by cyclic GMP–AMP synthase (cGAS), which elicits the production of type I interferons by generating the second messenger 2?3?-cyclic-GMP–AMP (cGAMP). Show More Summary

The cryo-electron microscopy structure of human transcription factor IIH

Human transcription factor IIH (TFIIH) is part of the general transcriptional machinery required by RNA polymerase II for the initiation of eukaryotic gene transcription. Composed of ten subunits that add up to a molecular mass of about 500?kDa, TFIIH is also essential for nucleotide excision repair. Show More Summary

Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring

Maternal immune activation (MIA) contributes to behavioural abnormalities associated with neurodevelopmental disorders in both primate and rodent offspring. In humans, epidemiological studies suggest that exposure of fetuses to maternal inflammation increases the likelihood of developing autism spectrum disorder. Show More Summary

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis

Pericyclic reactions—which proceed in a concerted fashion through a cyclic transition state—are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon–carbon bonds. They have...Show More Summary

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors

Long-term potentiation (LTP) of excitatory synaptic transmission has long been considered a cellular correlate for learning and memory. Early LTP (less than 1?h) had initially been explained either by presynaptic increases in glutamate...Show More Summary

Alternative evolutionary histories in the sequence space of an ancient protein

To understand why molecular evolution turned out as it did, we must characterize not only the path that evolution followed across the space of possible molecular sequences but also the many alternative trajectories that could have been taken but were not. Show More Summary

The Apostasia genome and the evolution of orchids

Constituting approximately 10% of flowering plant species, orchids (Orchidaceae) display unique flower morphologies, possess an extraordinary diversity in lifestyle, and have successfully colonized almost every habitat on Earth. Here...Show More Summary

A spin transition mechanism for cooperative adsorption in metal–organic frameworks

2 weeks agoAcademics : Nature AOP

Cooperative binding, whereby an initial binding event facilitates the uptake of additional substrate molecules, is common in biological systems such as haemoglobin. It was recently shown that porous solids that exhibit cooperative binding...Show More Summary

Cell signalling: Red alert about lipid's role in skin cancer

2 weeks agoAcademics : Nature AOP

Some versions of the MC1R protein are associated with red hair and an increased risk of developing a skin cancer called melanoma. It emerges that a lipid that binds MC1R might provide a target to reduce this risk.

Cell biology: The persistence of memory

2 weeks agoAcademics : Nature AOP

Live imaging reveals that whether or not a daughter cell proliferates is influenced by two molecular factors inherited from its mother, providing insight into how the behaviour of a newly born cell can be predetermined.

Leukaemia: Vitamin C regulates stem cells and cancer

2 weeks agoAcademics : Nature AOP

It emerges that high levels of vitamin C in blood-forming stem cells influence the number and function of the cells and affect the development of leukaemia, through binding to a tumour-suppressor protein, Tet2.

Structural basis of MsbA-mediated lipopolysaccharide transport

2 weeks agoAcademics : Nature AOP

Cryo-electron microscopy snapshots of the E. coli flippase MsbA at discrete functional states reveal a ‘trap and flip’ mechanism for lipopolysaccharide flipping and the conformational transitions of MsbA during its substrate transport cycle.

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