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A Cancer Surprise

16 hours agoHealth / Aging : Time Goes By

Thank you all for your concern and suggestions on Wednesday's post about my fatigue. I wrote that post late on Tuesday anticipating my regular chemo session the next afternoon. It did not go exactly as planned. First, you would not....

Brain astrocytes linked to Alzheimer's disease

Astrocytes, the supporting cells of the brain, could play a significant role in the pathogenesis of Alzheimer's disease (AD), according to a new study. This is the first time researchers discovered a direct association between astrocytes and AD.

Large decrease in age-related macular degeneration in baby boomers compared to previous generations

The risk of developing age-related macular degeneration is much less in the Baby Boom (1946-1964) and later generations than in earlier generations, for unclear reasons.

For older women, every movement matters

Women who engaged in 30 minutes per day of light physical activity had a 12 percent lower risk of death. Women who did a half-hour each day of moderate to vigorous activity had a 39 percent lower mortality risk.

Defenestration and the Roots of Age-Related Insulin Resistance

19 hours agoHealth / Aging : Fight Aging

Defenestration is apparently a word with two meanings. The second, a scientific term, is the removal or loss of fenestrations. Let it never be said that this is not a place of learning. What, one might ask, are fenestrations? This is...Show More Summary

Towards Better Artificial Alternatives to Cartilage Tissue

19 hours agoHealth / Aging : Fight Aging

It will be interesting to watch the accelerating development of biological versus non-biological replacements for damaged tissue over the next few decades. Both are improving at a fair pace, and there is a sizable area of overlap between the two sides of the field. Show More Summary

Stem Cell Therapy Partially, Unreliably Repairs Spinal Cord Injuries in Rats

19 hours agoHealth / Aging : Fight Aging

Engineering regeneration of an injured spinal cord is one of the fields to watch as a marker of capabilities in stem cell medicine. There is a fair amount of funding and effort directed towards this goal, and it requires overcoming a number of issues that are relevant to other types of regenerative medicine. Show More Summary

Mild Mitochondrial Stress Found to Prevent Some of the Age-Related Declines in Cellular Maintenance in Nematodes

19 hours agoHealth / Aging : Fight Aging

Hormesis is a near ubiquitous phenomenon in living organisms and their component parts: a little damage, a short or mild exposure to damaging circumstances, can result in a net benefit to health and longevity. Cells respond to damage...Show More Summary

The Results of Most Potential Biomarkers of Aging Vary Considerably

19 hours agoHealth / Aging : Fight Aging

As expected, a study finds that the numerous candidate biomarkers of aging vary widely in their assessments of biological age. This makes complete sense, as (a) aging is caused by a number of distinct processes of damage accumulation,...Show More Summary

A Profile of James Clement's Supercentenarian Research

2 days agoHealth / Aging : Fight Aging

Should James Clement's name remain well-known in association any of the present day work on human longevity, one would hope it will be as one of the pioneers to first organize trials of senolytic therapies in humans, via his Betterhumans organization. Show More Summary

Human PAI-1 Loss of Function Mutants Found to Live Seven Years Longer than Peers

2 days agoHealth / Aging : Fight Aging

Researchers have found a noteworthy effect on longevity in a small study population that includes the only known individuals with a loss of function mutation in plasminogen activator inhibitor-1 (PAI-1). Individuals with the mutation live seven years longer on average than near relatives without it. Show More Summary

Critical Care Recovery Center concept could benefit adult ICU survivors of all ages

A Critical Care Recovery Center could benefit ICU survivors of all ages, suggests new research. The model is America's first collaborative care concept focusing on the extensive cognitive, physical, and psychological recovery needs of ICU survivors and decreasing the likelihood of serious illness after discharge from an ICU.

The Reality of Cancer Treatment Sets In

3 days agoHealth / Aging : Time Goes By

As I sit here at my desk tapping out this first sentence, I'd rather be curled up in bed. I don't necessarily need to sleep; I just want to lie down. I am deeply weary. This is not an unexpected...

The Limits to Human Longevity, or Lack Thereof

3 days agoHealth / Aging : Fight Aging

This open access paper is a good resource if you happen to want a list of references to the mainstream scientific discussion of the past twenty years regarding trends in human life expectancy, and the predicted future of those trends. Show More Summary

Libella Gene Therapeutics Plans Human Telomerase Gene Therapy Trial

3 days agoHealth / Aging : Fight Aging

My attention was recently directed to another new group planning patient paid human trials of telomerase gene therapy. This is a company associated with Sierra Sciences and the RAAD Festival crowd, meaning the Life Extension Foundation principals. Show More Summary

A Review of the Recent History of Parabiosis Research

3 days agoHealth / Aging : Fight Aging

Today, a history of parabiosis studies, albeit one rather biased towards the idea that signals present in young blood might be used to produce benefits in the old. It is possibly a little early to be taking firm sides on that question given the contradictory research results to date. Show More Summary

Borderline Personality Disorder and Ability to Read Emotions

Being unable to decode emotions seems to be an inherent feature of borderline personality disorder but new research shows it’s not as inevitable as you might think.

A Klotho Gene Therapy Produces Long-Lasting Cognitive Enhancement in Mice

4 days agoHealth / Aging : Fight Aging

Klotho is a longevity-associated gene in mice and humans, but in recent years researchers have seemed more interested in delving into its effects on cognitive function. Now a team has demonstrated that one of the various forms of klotho...Show More Summary

Inhibiting Interleukin 11 can Suppress Fibrosis

4 days agoHealth / Aging : Fight Aging

The ability to reverse fibrosis would turn back some fraction of the progression of age-related failure in heart, kidney, lungs, and other organs. Fibrosis is a form of scarring in tissue that forms in place of functional structures,...Show More Summary

Giving Tuesday Approaches: Help us to Fund SENS Rejuvenation Research

5 days agoHealth / Aging : Fight Aging

Giving Tuesday is two weeks away, on November 28th. As manufactured celebrations go, I think we could do far worse than a holiday that encourages philanthropy. While most people are basically well-meaning, and I think would agree in principle that support for medical research is to the common good, we all lead busy lives and need prompting. Show More Summary

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