The practice of calorie restriction produces sweeping changes in the operation of cellular metabolism and acts to modestly slow the progression of aging, extending life in most species and lineages tested to date. The focus in this open...Show More Summary
The LongeCity community is presently building a small fund from philanthropic donations in order to help support a selection of affliate laboratories involved in the development of therapies to treat aging as a medical condition. InShow More Summary
As you may be aware, a faction at the National Institute on Aging has for some years run the Interventions Testing Program (ITP). The objective is to pick out methods shown in the past to extend life span in mice, and rigorously rerun those studies in order to obtain gold standard data that definitively proves or disproves effects on aging. Show More Summary
Protests work. We who are old enough learned that first hand back in the 1960s when we stopped a war, helped force through civil rights legislation and made a big leap forward with women's rights. And it's true again in...
The practice of calorie restriction is shown to slow the progression of aging and extend healthy life in most species and lineages tested to date, including non-human primates. In humans the degree of life extension is a question mark,...Show More Summary
The paper here provides an interesting perspective on the formation of solid aggregates of misfolded or damaged proteins with age, one of the distinguishing features of old tissues. There are numerous types of such aggregate, varying by tissue, and a mix of evidence for their contribution to specific aspects of aging or specific age-related diseases. Show More Summary
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary
Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model organisms. Yet, how these different aging genes and pathways are interconnected remains poorly understood. Show More Summary
A powerful class of antibiotics provides life-saving relief for people with cystic fibrosis; however, a new study for the first time reveals the levels at which high cumulative dosages over time significantly increases the risk of permanent hearing loss in these patients. Show More Summary
We tend to believe that a simple smile is enough to grease the social wheels of life. New research shows when suppression may be the better, and kinder, part of valor.
There is such an abundance this week of “interesting stuff” that I hardly knew where to begin. Here are some of them. MONOPOLY KILLS THE THIMBLE Yes, it's true. Last month, four million Monopoly fans voted on which game tokens...
A great diversity of microbial life dwells inside us all, largely in the gut, and these microbes interact with our tissues and immune system in ways that the research community has only recently started to map in earnest. There are a...Show More Summary
That headline is a more interesting question, I think, for people of the general age (50- or 60-plus) who read this blog than younger people. As it turns out, two new studies released just this week has some answers. One...
Misfolded transthyretin accumulates with age, forming solid amyloid deposits in tissues, particularly in the cardiovascular system. Amyloid disrupts proper function of cells and organs, and this is likely the majority cause of death in supercentenarians, the oldest humans. Show More Summary
Overpopulation is one of the great apocalyptic fears of our era, and like many of the rest of those fears, it is unfounded. If anything, the trajectory is for increased wealth to reduce population as children shift from being a necessary benefit to what is effectively a form of luxury good. Show More Summary
It has been a decade or so since the first induced pluripotent stem (iPS) cells were produced. Researchers discovered a recipe by which ordinary, limited, adult somatic cells could be reprogrammed into a state near identical to thatShow More Summary
An anti-diabetic drug can inhibit the growth of melanoma in older patients by activating an anti-aging gene that in turn inhibits a protein involved in metastatic progression and resistance to targeted therapies for the disease, new research indicates.
A new study has shown evidence linking the biology of aging with idiopathic pulmonary fibrosis, a disease that impairs lung function and causes shortness of breath, fatigue, declining quality of life, and, ultimately, death. Researchers believe that these findings are the next step toward a possible therapy for individuals suffering from idiopathic pulmonary fibrosis.
Older people who suffer from back pain have a 13 per cent increased risk of dying from any cause, research has found. The study of 4390 Danish twins aged more than 70 years investigated whether spinal pain increased the rate of all-cause and disease-specific cardiovascular mortality.