The Methuselah Foundation has unveiled the Methuselah 300 monument in the US Virgin Islands, a lasting record of all of the generous donors who have helped fund the work of the Methuselah Foundation over the past decade: the M PrizeShow More Summary
It is no big secret that regular exercise and greater fitness leads to better health and a longer life expectancy, though it remains uncertain as to where the point of greatest benefit lies. What is the dose-response curve for exercise?...Show More Summary
The evidence for metformin to slightly slow the aging process is all over the map. It is sketchy and contradictory in comparison to the robust results from rapamycin, for example. This isn't preventing a coalition of researchers from...Show More Summary
Epigenetic changes occur constantly, altering the production of proteins in response to circumstances, and thus changing cell and tissue behavior. Some of these changes occur in reaction to the cell and tissue damage of aging, and are...Show More Summary
Here I'll point out a recent addition to the set of open data interfaces that are both interesting and relevant to aging research: the MitoAge database, cataloging mitochondrial DNA and longevity in a wide range of species. Mitochondria, the descendants of ancient symbiotic bacteria, swarm in herds inside our cells. Show More Summary
In some patients Parkinson's disease is associated with genetic variants, most likely because those differences increase susceptibility to damage in the small but critical population of neurons that are destroyed as the disease progresses. Show More Summary
A SHORT NOTE: Before I get to the holiday part of today's story, let me mention that I will soon be posting the annual gift ideas for elders column. If you have a suggestion or more, please forward them to...
Should we build rejuvenation therapies? Hell yes. Are we? Barely, as nowhere near enough of an effort is being made. This is an opinion piece by Aubrey de Grey of the SENS Research Foundation: Aging is a hot topic among the chattering classes these days. Show More Summary
Insults live at the bottom of the scale of socially appropriate behavior. Because our first tendency is to be polite, especially with people we don’t know very well, it’s not always clear whether to respond in kind or turn the other cheek. Here’s some guidance for how to handle these confusing situations.
Here I'll point out the latest in the Question of the Month series from the SENS Research Foundation, in which the staff are far more polite than I regarding the unmerited hype that seems to accompany both supplement research in general...Show More Summary
Type 1 diabetes is an autoimmune disease, type 2 diabetes is a lifestyle disease largely caused by being overweight, some researchers have suggested that Alzheimer's disease is a type 3 diabetes, and here evidence is presented for the...Show More Summary
Giving Tuesday is the Black Friday of the non-profit world, a collaborative event organized across the whole of the non-profit community in which activists and advocates raise awareness, coordinate activities, and inform the decisions that people make about charitable donations at the end of the year. Show More Summary
Even many old people deny it exists but ageism is a serious problem. In just one manifestation of its impact, age discrimination in the workplace begins as early as age 40 and picks up speed from there. Often, when workers...
A researcher here takes a skeptical look at telomerase studies, such as those shown to extend life in mice, most likely by boosting stem cell activity. There is a school of thought that suggests the role of telomerase in lengtheningShow More Summary
Here I'll point out a view of the great divide in aging research from the other side. I have long argued that the most important divide in the field of aging research is between (a) the minority position of those who see aging as anShow More Summary
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
From a mental health standpoint, you should be more likely to browse through the Facebook posts of your friends and acquaintances to make yourself feel better. The reality is that social networks can just as often stimulate the unpleasant emotions of shame and envy. Here's how to shrug off those posts that peeve you.
THE SHAMEFUL XENOPHOBIA OF OUR SMALL-MINDED POLITICIANS As has become evident in the past few days, the xenophobia, hatred and racism among a large number of our politicians and presidential candidates has moved on from prudence to hysteria. A small,...
Earlier this year researchers published evidence suggesting that rising levels of transthyretin (TTR) amyloid may contribute to age-related damage to cartilage tissue in joints and consequent development of osteoarthritis. Amyloids of...Show More Summary
Well, not exactly but it's just as good as far as I'm concerned. Let me explain. About three years ago, I set out to lose the 40 pounds I had allowed myself to gain after I retired in 2004. That...