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A Desire for Improved Vaccine Effectiveness as the Spur to Invest in Potential Methods of Immune System Rejuvenation

4 hours agoHealth / Aging : Fight Aging

In the same way that the regenerative medicine field cannot evade addressing the aging of stem cells, the vaccination research community cannot evade addressing the aging of the immune system. The reasons are much the same in both case:...Show More Summary

Wnt Signaling and p53 in the Progression of Heart Failure

4 hours agoHealth / Aging : Fight Aging

If at the bottom of aging are root causes, and at the top of aging are end results, meaning organ and tissue failure and age-related disease, then the majority of aging research is focused on the middle layer of the problem in between. Show More Summary

Marketing to Baby Boomers - The Power of Generational Experiences and Values

13 hours agoHealth / Aging : Boomers

Generational Sociology and Boomers Karl Mannheim, a founding father of the field of sociology, conceived the essence of generational theory through a seminal 1923 essay entitled "The Problem of Generations." Mannheim insisted that when...Show More Summary

The Old-Fashioned Approach to Delivery and Targeting of Gene Therapy for Arthritis

16 hours agoHealth / Aging : Fight Aging

Sometimes the old-fashioned, simple solution is more than sufficient for the task at hand. In today's open access review paper, researchers discuss the delivery and targeting of gene therapies to arthritic joint tissue via the simple...Show More Summary

A new assessment method for active aging

Researchers have developed a new indicator for assessing active aging. Active aging refers to having initiative and doing things the aging person considers important. The indicator consists of a series of questions, which can be presented either in an interview or as a questionnaire. A score describing active ageing is calculated based on the responses. 

Great Big Fat Good News About Cancer

At first, I wrote this post with a long and winding introduction to the news – this great big fat good news - but that doesn't seem fair so I'm redoing it and adding what had been intro material as...

Evidence for Human Species Longevity to be a Matter of Many Small Adaptations

yesterdayHealth / Aging : Fight Aging

Why do humans live so much longer than other, short lived species? The researchers here provide evidence to suggest that it is a matter of many small changes, with the specific area of investigation being the the cellular repair mechanisms of autophagy. Show More Summary

Even Modest Changes in Calorie Intake and Weight can Ruin any Study of Health

yesterdayHealth / Aging : Fight Aging

Calorie restriction has a large beneficial effect on health and longevity in mice, and as a result any number of studies carried out over the past century were ruined - usually without the researchers noticing - because no attempt was made to control for calorie intake and weight. Show More Summary

Fight Aging! Newsletter, January 22nd 2018

yesterdayHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

ELDER MUSIC: Classical Gas Part 9

2 days agoHealth / Aging : Time Goes By

This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...

Which Personality Disorders Do Your Favorite Actors Have?

You may believe that all actors have narcissistic traits in a professional that rewards egotism. New research on the personalities of real actors shows you're only partly right.

Slower walking speed in the elderly may be explained by loss of muscle strength and mass

Research has found that elderly people walk at a slower speed and tire more quickly because of loss of strength and mass in leg muscles. Using computer simulations they found that these physiological changes explain the slower walking speed preferred by the elderly, and that a focus on building up these leg muscles may be the only effective way to improve elderly walking.

INTERESTING STUFF – 20 January 2018

3 days agoHealth / Aging : Time Goes By

LIVE JAZZ EVERY SUNDAY IN HARLEM APARTMENT Every Sunday, Marjorie Eliot and Rudel Drears open the doors of their Harlem apartment to anyone in the mood for jazz. At first, this was a way for Marjorie to honor her son’s...

Senescent Cells are Large, which Suggests a Few Simpler Paths to Assays for Senescence Level in Human Subjects

3 days agoHealth / Aging : Fight Aging

The rise in number of senescent cells with age is one of the root causes of degenerative aging. Somatic cells become senescent when they reach the Hayflick limit on replication, or become damaged, or encounter a toxic environment. They cease replication, and either self-destruct or are destroyed by the immune system. Show More Summary

Crabby Old Lady and Protest/Donation Fatigue

4 days agoHealth / Aging : Time Goes By

But first – we have a winner in Monday's random drawing for a book of essays by Ursula K. Le Guin titled No Time to Spare. The random number generator spoke and Karin Bendel's name came up. The book has...

The Prospect of Filtering Harmful Factors from Old Blood

4 days agoHealth / Aging : Fight Aging

The Life Extension Advocacy Foundation volunteers here interview Irina and Michael Conboy, two of the more influential scientists involved in parabiosis research. When the circulatory systems of an old mouse and a young mouse are connected,...Show More Summary

Suggesting that Only Minimal Loss of Synapses Occurs in Alzheimer's Disease

4 days agoHealth / Aging : Fight Aging

There are signs from past years to suggest that Alzheimer's disease is a reversible condition, at least in its earlier stages. In other words, that there is little loss of the structures holding the data of the mind, and the condition degrades the operation of the mind, not its underpinnings. Show More Summary

Aubrey de Grey on Ending Aging and the Relative Merits of Various Approaches

4 days agoHealth / Aging : Fight Aging

Here is the transcript of an interview, published last week, with Aubrey de Grey, advocate and coordinator of rejuvenation research, originator of the Strategies for Negligible Senescence (SENS) scientific programs, and cofounder of the Methuselah Foundation and SENS Research Foundation. Show More Summary

Evidence for mTOR to be Involved in Vascular Aging and thus Vascular Dementia

5 days agoHealth / Aging : Fight Aging

Research into mTOR and aging is becoming quite diverse. Researchers here present evidence for mTOR to be involved in the aging of the vasculature, and thus also in the development of vascular dementia. One of the noteworthy aspects of...Show More Summary

Torin1 as an Example of the Search for Better Rapalogs, with a Focus on Autophagy

5 days agoHealth / Aging : Fight Aging

A sizable portion of the research community interested in intervening in the aging process searches for ways to mimic naturally occurring stress responses, those linked to a slowing of aging in animals. Much of this research in some way involves TOR, the target of rapamycin, and attempts to improve upon rapamycin as a drug candidate to inhibit TOR. Show More Summary

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