A lot of important, even crucial things in life are really dry and boring to read. This is one of them. So I've arranged a treat for you at the end, but only if you read all the way through....
The work noted here is targeted at curing autoimmune conditions by removing the misconfigured immune cells that attack important infrastructure in tissues. This is good news for all autoimmunity in which the relevant biochemistry isShow More Summary
As we all well know, the adaptive component of the immune system deteriorates with age for a number of reasons. There is the toll of cell and tissue damage, there is a structural issue in which too many cells become uselessly devoted...Show More Summary
In the scientific commentary I'll point out today, the authors advocate for the expansion of efforts to target mutations of the cancer suppressor gene TP53, encoding the protein p53, as a path to cancer therapies that might be broadly applicable to many cancer types. Show More Summary
Why do narcissists tend to view themselves in the most positive light possible?
Aging kills all of us eventually, given how little today's medical technology can do to intervene in the causes of age-related degeneration, but along the way there is a quite a distribution of outcomes in health and frailty. Some people live longer than others, obviously. Show More Summary
This is a fairly interesting take on reducing the impact of heart attacks. It isn't the best approach to the situation, which is to find methods of prevention, but rather a matter of engineering the heart to be more resilient to temporary...Show More Summary
While aging is complex, and so is diet, the recommendations are fairly straightforward: practice calorie restriction and you'll find that most of the other pieces of a sane diet fall into place by themselves, as it is very hard to assemble a calorie restricted diet out of anything other than healthy food. Show More Summary
Researchers continue to search for better methods of 3-D printing to build tissues, approaches capable of producing the correct structural properties in the resulting product. Cartilage is a challenge in particular, as while it is aShow More Summary
I just made that up: elder tweens. The word “tween” is new since I was young and although the age parameters vary depending on who is talking, it is the name given to an unofficial stage of life somewhere between...
Researchers have recently investigated one of the numerous mechanisms by which regular exercise acts to improve brain function over the long term. In this case, there is a chain of interactions that leads via cathepsin B to the better known brain-derived neurotrophic factor (BDNF) that then boosts neurogenesis, the creation of new brain cells. Show More Summary
There are any number of ways to make mice live a little longer by slowing the accumulation of cell and tissue damage that causes age-related degeneration. Processes such as the cellular repair mechanisms of autophagy, for example, influence...Show More Summary
We want and expect our romantic partners to be completely open, but when they fall short, these are the 4 mistakes you need to avoid.
We want and expect our romantic partners to be completely open, but when they fall short, what’s the best way to cope?
Using a mouse model of Parkinson's disease, researchers here demonstrate that c-Abl is associated with the accumulation of misfolded and toxic ?-synuclein that is involved in the progression of this degenerative condition. They manage...Show More Summary
You might find this interview interesting. It is illustrative of the views of many in the industry, with the primary focus being on continued exploration of the molecular biochemistry of aging in order to identify drug targets and drug...Show More Summary
Is aging a disease? The answer to that question really only matters to the degree that it can be used to bring funding into the better portions of aging research, those focused on treating aging as a medical condition. All age-related disease is caused by aging. Show More Summary
You might not think that the Brexit vote in the United Kingdom last week falls under the purview of a blog about growing old. And on the face of it, you would be correct. But not this time. If you've...
Nicotinamide mononucleotide (NMN) is one of a small number of molecules that might very modestly slow some of the effects of aging, based on a few initial results from animal studies. Recently, news has emerged of a forthcoming small trial in humans to be conducted by the Japanese research community. Show More Summary
Laura Deming has worked with the SENS Research Foundation and others on the molecular biology of aging, and a few years back helped organize the Longevity Fund to invest in startups relevant to the treatment of aging as they emerged....Show More Summary