People with narcissistic personality tendencies, who constantly need to see themselves as the center of attention, can be annoying to say the least. If you care about someone whose narcissism tends to get out of control, these 8 strategies will help you keep their egos, and your anger, under control. read more
Senescent cells rise in number with aging, in an evolved adaptation of developmental machinery that at least initially reduces cancer risk by removing potentially damaged cells from the cycle of division and replication. Many senescent...Show More Summary
Proteostasis is a shorthand term used to mean that the balance of proteins in cells remains steady and correct over time: proteins are produced and destroyed at more or less the same pace, relative levels of different proteins in different places in cells remain the same, levels of damaged proteins are low and consistent, and so forth. Show More Summary
Comparative study of the biology of aging in species with widely divergent life spans is undertaken by a number of groups in the broader research community. The idea here is that, especially in the case of similar species that nonetheless...Show More Summary
There is a range of evidence to suggest infection by various fungi, bacteria, and viruses might contribute to the development of Alzheimer's disease (AD), all of this being somewhat unrelated to evidence suggesting that Alzheimer's is a lifestyle disease created by many of the same root causes as type 2 diabetes, such as obesity and lack of exercise. Show More Summary
Aubrey de Grey is cofounder of the SENS Research Foundation, one of the few groups presently coordinating and funding serious scientific work on ways to repair the root causes of aging: Marty Nemko: You claim that the public is indifferent to, even resistant to, efforts to extend lifespan. Show More Summary
Last Wednesday, I offered up an extra copy I have of Julian Barnes' brilliant memoir of grief, Levels of Life. It was a random drawing and all you needed to do to participate was to leave a comment stating you...
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
THE ALS ICE CHALLENGE Unless you've been under a rock for the past week, you know about the ALS Ice Bucket Challenge during which mostly celebrities and politicians who want a few more minutes than usual in the spotlight sit...
There exists a very long history of people starting explicitly religious movements to achieve secular goals in the mundane world. A very broad range of such ventures can be found even in recent history, in this apostate age of comparatively weak and apolitical mainstream religious institutions. Show More Summary
Ever since Facebook launched in 2004, and even moreso following Twitter's online birth two years later, people who think they are in the know have been predicting the death of blogging – translation: long-form writing. The prognosticators often include the...
Transcranial magnetic stimulation (TMS) is a fascinating field of study in which it is clearly possible to affect the brain, but researchers are still in the comparatively early stages of finding out how to reliably produce and measure useful end results. Show More Summary
Cartilage regeneration and tissue engineering has proven more difficult than initially expected. It is a tissue with a deceptively complex structure, in which important mechanical properties necessary to its load-bearing role are derived from the details of that structure. Show More Summary
João Pedro de Magalhães is one of the few rising notables in the aging research community who has, from day one of his career, been absolutely and openly in favor of radical life extension through progress in medical science. To hisShow More Summary
On Tuesday's post about not having borne children and therefore having an old age without grandchildren, Karen Swift mentioned this in her comment: ”My first grandchild will arrive in November...I have been thinking a lot about exactly what kind of...
Many research groups in the stem cell field are engaged in a search for sources of useful tissue-specific cells in the body, developing means of identification and isolation. This runs in parallel with efforts to reprogram more easily obtained cells, such as from skin samples, into a range of different types for therapy and research. Show More Summary
A mountain of evidence exists to demonstrate that being sedentary will lead to greater ill health and a shorter life expectancy. As we inch closer towards the implementation of rejuvenation treatments at some uncertain point in the decades...Show More Summary
There are a score or more ways to reliably slow aging in mice, methods that include a few classes of drug, various single gene alterations, and calorie restriction. The most exceptional of these methods extends life by 60% or so, but most are in the much more modest 10-20% range at best. Show More Summary
I discovered the English writer, Julian Barnes, in 1984 with the publication that year of Flaubert's Parrot, and I haven't stopped reading him since. In the past decade, Barnes seems to have become almost as consumed with growing old, old...
This is an interesting technology demonstration that suggests an obvious pairing with regenerative treatments based on the use of stem cells or similar means to spur tissue repair. With regular scans it might be possible to preempt many...Show More Summary