Immune cells play an important role in regeneration, though this is yet another aspect of the immune system as a whole that is understood in outline but the all-important details remain a big blank space in the middle of the map. The...Show More Summary
[EDITORIAL NOTE: It tells you something about Crabby's week, if not life, that you are getting missives (read: complaints) from her two days in a row. Aren't you lucky. Every day, Crabby Old Lady struggles to keep up with email....
Alzheimer's disease is the name given to the end state of rising amyloid levels in the brain: it is the stage at which the patient has a lot of amyloid and is severely impacted by it. But we will all suffer increased levels of amyloid to some degree, and we will all be negatively affected by it to some degree. Show More Summary
The first stage of success in tissue engineering of any specific organ is to produce small sections of tissue that are close enough to the real thing to be used in research. Given a methodology to reliably produce these tissue sections...Show More Summary
I don't normally point out funding press materials, preferring to focus on the other end of the research process, but this one, drawn to my attention by the Healthspan Campaign newsletter, contains a good overview of the current state of knowledge regarding the persistent herpesvirus called cytomegalovirus (CMV) and its role in immune aging. Show More Summary
Before she even gets started, let Crabby Old Lady be clear: she is deeply grateful that so far – at age 73 – she has escaped the common conditions and diseases of old age. No arthritis, heart disease, diabetes, high...
One of the root causes of degenerative aging is the accumulation of sugary metabolic wastes known as advanced glycation end-products that are in some cases very hard to for our evolved biochemistry to break down. Some types can form cross-links, gluing together important proteins such as those making up the supporting extracellular matrix scaffold. Show More Summary
Researchers are digging in to some of the proximate mechanisms that lead to menopause, and making some progress by the looks of it. This is a good example of the general approach to aging taken by the research community: start at the...Show More Summary
We live in an age of rapidly advancing biotechnology, and research communities are on the verge of developing actual, real, working rejuvenation treatments. Given the funding there are lines of research under way today that might take the ills of aging and turn them back. Show More Summary
Everyone can relate to relationship break-up strategies that failed miserably. The key to minimizing the pain is to adjust the strategy to your personality and that of your partner. It may even be possible for you to improve your relationship breakup strategy with a simple mental adjustment. read more
Cell therapies and tissue engineering benefit from being able to use a patient's own cells as a starting point. If the patient is old, as is the case for most potential uses of regenerative medicine, cells are tissues are damaged and dysfunctional. Show More Summary
”This has to be one of the modern circles of hell, stroke. Or should we call it our plague? One day my mother is walking two miles on the beach and doing crossword puzzles in ink. The next day her...
Researchers here uncover an interesting role for one of the forkhead box (FOX) proteins, and the potential basis for a treatment for pulmonary hypertension: An estimated 100 million people worldwide suffer from pulmonary hypertension. Show More Summary
Citations in an academic paper have some similarities to links in the web, or at least in the case where those links are a result of human choice and consideration. Considered in the abstract, a citation is a vote of attention rather than an opinion on the contents of the cited paper. Show More Summary
If you read Peter Tibbles' Elder Music column yesterday, you know that he and Norma Gates, the Assistant Musicologist, traveled all the way from Melbourne to visit me in Oregon. Oh, okay. The journey wasn't just to see me. They...
Mitochondria are the bacteria-like power plants of the cell, thousands to each cell, and each mitochondrion bearing its own DNA separate from that in the cell nucleus. Damage to this DNA is important in aging, and in a variety of diseases. Show More Summary
Given a donor blood vessel, researchers can strip it of its cells to leave just the extracellular matrix structure. This can then be repopulated with a patient's own cells, making it possible to transplant the blood vessel without risk of rejection. Show More Summary
Cryonics involves the low-temperature preservation of the recently deceased, and as an industry it has been around for some decades. Using modern techniques and if the preservation is accomplished with speed, this can result in a good preservation of the fine structure of the brain, and thus of the data that makes up the mind. Show More Summary
The open access paper quoted below provides some insight into increasing sophistication of the work involved in identifying longevity-related genes and proteins in mammals. Many of these have been discovered over the past twenty years, leading to numerous ways to alter the operation of metabolism in order to slow aging and thus extend healthy life. Show More Summary
The evolution of cell therapies will most likely be towards treatments that alter cell type and behavior in place, drawing from the existing pool of cells and changing them to suit the needs of the patient. Given sufficient control over...Show More Summary