Mice lacking p21 can regenerate small wounds without scarring, something that is not normally possible in adult mammals. Separately, SDF-1 has been identified as a signal to recruit and activate stem cells, and efforts are underway build regenerative therapies on this basis. Show More Summary
This Monday begins the Democrats' turn to present, over the next four days, their vision for the future of the United States. Last week, the Republicans – well, never mind. The party hardly matters anymore. It is Trump unleashed now...
The press here reports on the positive results of a recent small trial of the introduction of stem cells during bypass surgery for heart attack survivors. Stem cell therapies have over the past decade demonstrated highly variable outcomes in patients, and the methodology of delivery has been shown to be very important. Show More Summary
FIGHT AGING! NEWSLETTER July 25th 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent...Show More Summary
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
In a time when opinions are key to almost any dialogue between people, you may wonder- what’s the best way to express yours? This simple approach will help you find your voice.
THE LAST CAROUSEL CRAFTSMEN Remember carousels? I loved them when I was a kid. I still do. I suppose for today's kids they seem tame compared to the thrill rides at big amusement parks. Too bad. They are so beautiful...
Science News recently lumped together a few popular science articles on aging research into a special issue on the subject. As the blurb notes, aging is very much neglected in comparison to its importance, and accepted despite the damage it does. Show More Summary
Most aging research starts in short-lived species far removed from our own in the tree of life. There is a trade-off involved: it is much cheaper to explore and experiment with interventions in aging in a short-lived species, but the more distant the species the less likely that the results will be useful for longer-lived mammals. Show More Summary
The stem cells responsible for muscle growth and regeneration are perhaps the best studied of such populations. It seems that most of the new and interesting insights into the nuts and bolts of stem cell biology are coming from this part of the field, in any case. Show More Summary
So far in my old age – I am 75 – I have been lucky in my health (I say that with multiple knockings on wood). I have no intrusive afflictions, no conditions, no diseases, nothing that requires medication. I...
Five years from now, it will be possible to take a trip overseas to have most of the senescent cells that have built up in your tissues cleared away via some form of drug or gene therapy treatment. That will reduce your risk of suffering...Show More Summary
Researchers have demonstrated the ability to build organoids of many different tissue types, starting with just a cell sample. The open access paper linked here is one example of many at the present time. These organoids are tiny sections...Show More Summary
Most people and most organizations consider the present to be a good model for the future, and base long-term plans on present trends. They are always surprised by change, despite living in an era characterized by rapid change driven by technological progress. Show More Summary
In recent news, researchers have identified CD47, mainly of interest in cancer therapies up until this point, as a potential therapeutic target to diminish the vicious circle of mechanisms that causes fatty plaques to grow in blood vessel walls. Show More Summary
The dark side of getting ahead involves cheating and sabotaging others. Lab research comparing the two sexes finds the dark side is more likely to be inhabited by men.
Cytomegalovirus (CMV) is one of the most prevalent of the many forms of persistent herpesvirus that our immune system cannot effectively clear from the body. It has few obvious immediate effects in most people, and you probably never noticed when you were first infected. Show More Summary
When I moved to Oregon in 2010, and needed a new physician, I used the internet to track down the geriatricians in my area. About half the listings included a note that the doctor was not taking new patients. When...
This popular science article examines a few of the current efforts to build the foundation for therapies to treat aging and its consequences, with a particular focus on parabiosis research in which the circulatory systems of old and young individuals are linked. Show More Summary
Always getting what you want is tempting, but also unrealistic. With some grit and goal-setting, you can get close.