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Nanodiscs catch misfolding proteins red-handed

When proteins misfold, accumulate and clump around insulin-producing cells in the pancreas, they kill cells. Now, researchers have obtained a structural snapshot of these proteins when they are most toxic, detailing them down to the atomic level.

Crabby Old Lady and the Things They Don't Tell You About Getting Old

9 hours agoHealth / Aging : Time Goes By

Crabby Old Lady will be here in a moment but for a few sentences this is me, Ronni. After I wrote today's post, members of the U.S. Federal Communications Commission (FCC) voted on Friday to kill Net Neutrality. A couple...

Cellular Senescence and Stem Cell Decline in Age-Related Cardiac Hypertrophy Caused by Hypertension

10 hours agoHealth / Aging : Fight Aging

Cellular senescence is one of the causes of aging; senescent cells accumulate in tissues, and their inflammatory and other disruptive signaling causes considerable harm. With the newfound and rapidly spreading interest in senescent cells...Show More Summary

Pineapple Fund Donates $1 Million In Bitcoins to the SENS Research Foundation

11 hours agoHealth / Aging : Fight Aging

The Pineapple Fund is one of the more sensible responses to sudden wealth that I've seen in my time, a charitable giving initiative set up by someone who finds themselves a multi-millionaire as a result of the enormous rise in the valuation of blockchain initiatives over the past couple of years. Show More Summary

Working on a More Detailed View of Muscle Stem Cell Aging

23 hours agoHealth / Aging : Fight Aging

The population of stem cells that supports muscle tissue is one of the better studied classes of such cell. Stem cells enable tissue maintenance and regeneration by delivering a supply of new daughter somatic cells that can multiple to make up losses, and through signaling that alters cell behavior. Show More Summary

The SENS Research Foundation Comments on Calico's Research into Apparent Rejuvenation in Oocytes

yesterdayHealth / Aging : Fight Aging

The normally secretive California Life Company, or Calico, recently shared some of their investigations into the rejuvenation that takes place in the earliest stages of the reproductive process - parents are old and children are young,...Show More Summary

Modest Physical Activity in Old Individuals Correlates with Reduced Cardiovascular Disease Risk

yesterdayHealth / Aging : Fight Aging

The study noted here can be added to the list of those that find modest activity to associate with reduced risk of cardiovascular disease risk in old people. This sort of finding is a comparatively recent development in epidemiology because it relies upon the use of accelerometers, of the sort found in every mobile device these days. Show More Summary

Idle Thinking on the Outcome when the Political Establishment Notices that Rejuvenation Therapies are Imminent

yesterdayHealth / Aging : Fight Aging

The political establishment is a plague upon the land; this is generally true of any era. We are fortunate to live in an age in which the level of impact is less brutal and more bureacratic than it has been, and in a region in whichShow More Summary

AG Sessions Aiming For Marijuana Prosecutions

2 days agoHealth / Aging : Time Goes By

Today's story is an update of one from 23 October 2017 titled Cannabis and Chemo about my first visit to a marijuana dispensary to see if I could find relief for my insomnia. Over-the-counter sleep aids don't work for me...

Cellular Senescence as a Failed Anti-Cancer Strategy

2 days agoHealth / Aging : Fight Aging

The evolution of multi-cellular life is in essence the story of a tooth and nail struggle with cancer, one that continues even now. Complex structure, regeneration, and growth are all required in higher forms of life, but that combination...Show More Summary

Easy Ways to Tell Whether You’re an Inadvertent Narcissist

There are several basic keys to understanding who’s a narcissist but what about if the narcissist is you? New research shows how to tell if without realizing you’re one yourself.

A Discussion of Cellular Senescence in Age-Related Macular Degeneration

2 days agoHealth / Aging : Fight Aging

Cellular senescence is one of the root causes of aging. A small fraction of the large number of cells that become senescent every day fail to self-destruct, and instead linger in tissues to secrete a mix of inflammatory and other harmful signals. Show More Summary

An Interview with Doug Ethell of Leucadia Therapeutics

2 days agoHealth / Aging : Fight Aging

Leucadia Therapeutics is a startup company focused on Alzheimer's disease, noteworthy for being one of the few ventures to depart from the orthodoxy of immunotherapy to clear amyloid and tau protein aggregates. The Leucadia staff are...Show More Summary

Epigenetic aging linked to bipolar disorder

Bipolar disorder may involve accelerated epigenetic aging, which could explain why persons with the disorder are more likely to have -- and die from -- age-related diseases, according to researchers.

People say they want to live longer -- if in good health

Individually most people only want to live long lives if they will be healthy, according to a new study.

Death Receptors as Biomarkers for Cardiovascular Mortality

3 days agoHealth / Aging : Fight Aging

Researchers here present evidence for the appropriately named death receptors to be biomarkers for cardiovascular disease risk, an indirect measure of the damage accumulating in the vascular system over the course of aging, and its effects on cellular biochemistry. Show More Summary

Yet More Evidence for Impaired Drainage of Cerebrospinal Fluid in Aging

3 days agoHealth / Aging : Fight Aging

Leucadia Therapeutics is one of the young companies shepherded by the Methuselah Fund, in this case working on an Alzheimer's treatment predicated on a theory of the disease that views impaired drainage of cerebrospinal fluid as an important cause. Show More Summary

Asking the Right Question: Do You Want to Live Longer, if Good Health is Guaranteed?

3 days agoHealth / Aging : Fight Aging

Historically, the public at large has shown themselves to be quite disinterested in living longer. Over the years I've been aware of the longevity science movement, it has always been a challenge to expand the community towards greater acceptance, support, and funding. Show More Summary

Rethinking Ageism

4 days agoHealth / Aging : Time Goes By

There has been a surge recently in the number of print media stories about ageism. Two I've seen are important. In November, Joseph F. Coughlin, who is founder and director of MIT’s AgeLab, noted in Time magazine that old people...

Young Plasma Improves Liver Function in Old Rats by Boosting Autophagy

4 days agoHealth / Aging : Fight Aging

In the research here, injections of blood plasma from young rats are shown to improve autophagy and liver function in old rats. This is interesting given the so far mixed evidence for young to old plasma transfer to be beneficial. There...Show More Summary

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