Every school classroom seems to have a class clown. The nightmare of most teachers, we know very little about what happens to them when they enter the world of work, home, and community. When they grow up, these “wits” or jokesters can also create havoc to the other adults who inhabit their world.
Amyloids are misfolded proteins that gather to form solid aggregates in tissues. Their presence grows with age and some types of amyloid are known to contribute to the pathology of specific age-related conditions: amyloid-? in Alzheimer's disease and misfolded transthyretin in senile systemic amyloidosis for example. Show More Summary
There has been some interest in deeper investigations of metabolism and aging in mammals via the study of hibernating species. For any stable altered state of metabolism, such as the calorie restriction response or hibernation, a greater understanding of the mechanisms involved may shed light on a range of issues. Show More Summary
The old are not as physically aged as they used to be. Today's old people are in better shape than their predecessors, with access to better medicine and having been exposed to a lesser burden of infectious disease and other causes of cell and tissue damage over the course of a lifetime. Show More Summary
You are STILL not getting a regular blog post. I'm going slowly, carefully and taking a lot of rest breaks so I don't pull out what's left of my hair. It is times like these that I desperately crave cigarettes....
A greater level of fitness in mid-life is shown in many large studies to correlate with improved health and greater life expectancy. The data from this study shows that increased fitness correlates with lower mortality from cardiovascular...Show More Summary
A number of researchers have pointed out similarities between some of the risk factors and mechanisms of type 2 diabetes and Alzheimer's disease, a few even going so far as to suggest that Alzheimer's should be classified as type 3 diabetes:...Show More Summary
There are days in life, it is said, that will become so troublesome there is no point in getting out of bed. I say nay. I say there are entire weekends in that category and now I know they can...
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
Without realizing it, you communicate our emotions to others through our behavior as well as our words. In the best of all possible worlds, you would communicate only the positive, and not the negative emotions to those in your social world. By communicating "micro-affections," you and your relationships will benefit.
MORE DATING FOLLOWUP You will recall we discussed elder dating in three posts over the past week or so. Darlene Costner send one more update for us. Enjoy: Daughter: Daddy, I am coming home to get married. Take out your...
Most threads of aging research start in studies of very short-lived species, most commonly the nematode worm C. elegans. These animals are cheap to maintain over the course of a study, live for only a few weeks, and are probably better understood at the cellular and genetic level than any other species. Show More Summary
It’s becoming socially more acceptable to admit to finding a mate online, but there remain many misconceptions about online dating. Find out your online dating IQ with this 8-item quiz that separates myth from reality.
Targeting myostatin and related biochemistry is well demonstrated to increase muscle mass and strength in mammals such as laboratory mice. There are even rare natural mutants, including a few cows and humans, who lack normal myostatin and are as a result exceptionally strong in comparison to their peers. Show More Summary
[PERSONAL NOTE: I've not been feeling well for a couple of days – a bad cold or mild flu (this year's vaccine missed a strain or two) – so when I take a few minutes off from napping, I'm writing...
The systematic loss of muscle mass and strength with age is given the name sarcopenia. One of the potential contributing causes involves progressive dysfunction in processing of the amino acid leucine, and this might in theory be partially offset by leucine supplementation in the diet. Show More Summary
The lesson to take away from the last fifteen years of study of the genetics of longevity is that genetic variation in humans is simply not all that important throughout most of life. Aging is caused by damage, and certainly during the...Show More Summary
Using the recent development of killifish as a model organism as a starting point, this popular science article looks at some of the more recent high profile developments in the study of aging. It largely takes the longevity dividend party line of talking about extending healthy life span without extending overall life span, however. Show More Summary
A number of lines of research suggest that the benefits of calorie restriction for health and longevity largely derive from increased cellular housekeeping processes such as autophagy. For example, the calorie restriction response requires neuropeptide Y (NPY), and here researchers explore the linkage of NPY with autophagy. Show More Summary
Or, for that matter, any other kind of information? There are some general rules of thumb that anyone with even minimal critical thinking skills probably uses: • Who is doing the writing? What are his/her credentials? (If there is n...