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Researchers find a potential target for anti-Alzheimer treatments

Scientists have identified a gene that may provide a new starting point for developing treatments for Alzheimer’s disease (AD). The USP9 gene has an indirect influence on the so-called tau protein, which is believed to play a significant role in the onset of Alzheimer’s disease. This discovery may open a new door to developing active ingredients to treat Alzheimer’s disease.

Glial Cell Gene Expression Changes as a Potential Biomarker of Aging

last weekHealth / Aging : Fight Aging

The development of robust and reliable biomarkers that reflect biological age is a necessary step for the future development of rejuvenation therapies. The existence of such biomarkers will make it much less expensive and time-consuming...Show More Summary

Transplant of Engineered Retinal Tissue Restores Light Sensitivity in Blind Mice

last weekHealth / Aging : Fight Aging

One of the challenges inherent in testing potential methods of restoring lost retinal function is that mice cannot readily explain the degree to which their sight is restored. So the researchers here can demonstrate restored light sensitivity...Show More Summary

News About Old People - 11 January 2017

Here are a few items I want to tell you about that do not quite fit Saturday's Interesting Stuff and are also not big enough or meaty enough for a post of their own. Even so, I think you might...

'Dementia gene' may guard against decline associated with parasitic disease

New research suggests that carriers of the Apolipoprotein E4 allele, which is the single strongest genetic predictor of Alzheimer's disease and is associated with cognitive decline and cardiovascular disease, may have a reduced risk of cognitive decline associated with parasitic diseases.

Protein build-up may trigger inflammation associated with Alzheimer's and other conditions

A recent review article points to the 'trigger' for the inflammatory response, caused by the immune system, that precedes Alzheimer's disease and other neurological conditions.

Amyloid and Tau have Synergistic Effects on the Progression of Alzheimer's Disease

last weekHealth / Aging : Fight Aging

Alzheimer's disease is both an amyloidosis and a tauopathy. The dysfunction and death of neurons is driven by rising levels of amyloid-? and altered forms of tau, both of which form solid deposits in brain tissue. The accumulation of...Show More Summary

The Key to Overcoming Insecurity

There are many possible sources of insecurity, but, according to new research, there’s one easy way to make those feelings go away.

What's the Best Way to Judge a Psychopath's Empathy?

We need the people we place our trust into to show they're empathic. New research shows why baby-kissing becomes such an important measure of psychopathy.

Older adults with obesity less responsive to memory training than those with lower BMIs

In first study to compare results of cognitive training by BMI category, scientists found that memory training provided only one-third the benefit to older adults with obesity than benefit it provided to older adults without obesity...

Glia, not neurons, are most affected by brain aging

The difference between an old brain and a young brain isn't so much the number of neurons but the presence and function of supporting cells called glia. In a new article, researchers who examined postmortem brain samples from 480 individuals...Show More Summary

Can a Psychopath Kiss a Baby, and Mean It?

Kissing a baby is often used as the supreme metaphor for showing you are an honest person. New research shows why it’s so important to us when judging someone’s true character.

The Adventurous are Undergoing Enhancement Gene Therapies

last weekHealth / Aging : Fight Aging

As I've been saying for the past couple of years, gene therapies are straightforward enough and cheap enough to carry out that people are doing it, usually quietly, but it is happening. You only have to be connected enough to know a biotechnologist or two with the right skills, as the example here shows. Show More Summary

GSK-3 Inhibitors Can Spur Tooth Regeneration to Fill Cavities

last weekHealth / Aging : Fight Aging

There are a number of very promising lines of work in dental regenerative medicine these days, in regenerating parts of teeth or whole teeth, and in preventing the causes of cavities and gum disease. Here, researchers have developedShow More Summary

Reviewing the Evidence for PAPP-A as a Target to Modestly Slow Aging in Mammals

last weekHealth / Aging : Fight Aging

Today I'll point out a review of one protein, pregnancy-associated plasma protein-A (PAPP-A), for which levels can be reduced or interactions inhibited in order to slow aging in mice. A decade ago, researchers claimed life extension on a par with calorie restriction in a study of mice lacking PAPP-A. Show More Summary

High cholesterol intake and eggs do not increase risk of memory disorders

A relatively high intake of dietary cholesterol, or eating one egg every day, are not associated with an elevated risk of dementia or Alzheimer's disease. Furthermore, no association was found in persons carrying the APOE4 gene variant that affects cholesterol metabolism and increases the risk of memory disorders, report researchers at conclusion of a new study.

Call To Action Now: Senate Confirmation Hearings This Week

EDITORIAL NOTE: This is much longer than I intended and that's just how it is today. There's more stuff to know these days than my ability, sometimes, to summarize. Remember when I told you last week that...

A Profile of UNITY Biotechnology

last weekHealth / Aging : Fight Aging

An accumulation of senescent cells is one of the causes of aging, and periodic removal of senescent cells is therefore one of the foundations for near future rejuvenation therapies. The first generation of these treatments will likely...Show More Summary

Addressing Naturalistic Objections to Extending Healthy Human Life Spans

last weekHealth / Aging : Fight Aging

Here I'll point out another of the articles going up at the Life Extension Advocacy Foundation, this time on the topic of the naturalistic fallacy where it occurs in opposition to healthy life extension. Our community would like to build...Show More Summary

Fight Aging! Newsletter, January 9th 2017

last weekHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

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