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Pimavanserin: Relief from psychosis in dementia, without devastating side-effects

New research has found that pimavanserin significantly improves psychosis symptoms in people with Alzheimer's disease, without the devastating side-effects of currently used antipsychotics. The research found an even greater benefit in those with the most severe psychotic symptoms.

Alzheimer's disease reversed in mouse model

Researchers have found that gradually depleting an enzyme called BACE1 completely reverses the formation of amyloid plaques in the brains of mice with Alzheimer's disease, thereby improving the animals' cognitive function. The study raises hopes that drugs targeting this enzyme will be able to successfully treat Alzheimer's disease in humans.

Ivanka Trump, Social Security and Valentine's Day

TIME GOES BY DONATION WEEK REMINDER This is day three of the 2018 TGB donation drive to help support the increasing costs of maintaining Time Goes By. You can read the details on Monday's post. Whether you donate or not,...

Liver Organoids Come Ever Closer to Natural Liver Tissue

last weekHealth / Aging : Fight Aging

Tissue engineers continue to improve the quality of their creations. The liver is one of the easier organs to work with, given the much greater regenerative capacity of liver cells. It is, nonetheless, an organ with a complex small-scale internal structure, and getting that right is a process of incremental advances. Show More Summary

DNA Machinery that can Sabotage the Blood Supply of Tumors

last weekHealth / Aging : Fight Aging

Researchers have been building simple molecular machines out of DNA for some years now. This approach to molecular machinery is well suited to applications that involve conditional activation based on the proteins present in the surrounding...Show More Summary

Weaponizing the Biochemistry of Huntington's Disease as a General Cancer Therapy

last weekHealth / Aging : Fight Aging

An interesting observation that has arisen over the years of epidemiological study of human age-related disease is that there are a number of distinct inverse relationships between incidence of cancer and incidence of some forms of neurodegeneration. Show More Summary

Medical cannabis significantly safer for elderly with chronic pain than Opioids

A new study found cannabis therapy is safe and efficacious for elderly patients who are seeking to address cancer symptoms, Parkinson's disease, post-traumatic stress disorder, ulcerative colitis, Crohn's disease, multiple sclerosis, and other medical issues. Show More Summary

Identity in Borderline Personality Disorder: A New Approach

Borderline personality disorder is often thought of in terms of early development of the self. A new measure of identity shows the continuing role of identity in adulthood.

Evidence for Tau Accumulation and Failing Cerebrospinal Fluid Clearance to be the Starting Point for Alzheimer's Disease

last weekHealth / Aging : Fight Aging

Alzheimer's disease might be considered as the consequence of the related, interacting buildup of two primary forms of metabolic waste in the brain, tau and amyloid-?. Either, independently, can cause neurodegeneration, but they have a complicated relationship with one another in which the presence of both makes the pathology worse. Show More Summary

Inhibition of Wnt Signaling as a Treatment for Osteoarthritis

last weekHealth / Aging : Fight Aging

Researchers here find that inhibition of Wnt signaling can improve the state of cartilage and joint function in a mouse model of osteoathritis. Wnt and its closely related proteins are a complex topic, but the short version is that they are involved in the regulation of growth, regeneration, and embryonic development. Show More Summary

Can Two Dozen Marginal Ways to Treat Aging be Combined into One Useful Therapy?

last weekHealth / Aging : Fight Aging

Comparatively little work on combinations of therapies takes place in the research community. I suspect this to be a matter of regulatory incentives. For example there is little room for commercial entities to be able to make money by combining established treatments owned by other entities. Show More Summary

Annual TimeGoesBy Donation Week 2018

Here I am having been annoyed all week by the constant drumbeat of NPR's winter donation drive and now find myself kicking off the annual donation drive for TimeGoesBy. Inconsistency thy name is Ronni. I'll try to keep the irritatio...

There are Many Possible Paths to Immunotherapy for Senescent Cell Destruction

last weekHealth / Aging : Fight Aging

Rising numbers of senescent cells are one of the root causes of aging, a process that arises from the normal operation of youthful metabolism, yet results in accumulated damage and failure over time. Senescent cells generate signaling...Show More Summary

Jagged-1 as a More Selective Signal to Spur Bone Regrowth

last weekHealth / Aging : Fight Aging

Researchers here report on a more selective way to trigger the accelerated or enhanced regeneration of bone tissue, delivering jagged-1 to injuries rather than the bone morphogenetic proteins (BMPs) that have been used in the past. It...Show More Summary

One in five older adults experience brain network weakening following knee replacement surgery

A new study finds that 23 percent of adults age 60 and older who underwent a total knee replacement experienced a decline in activity in at least one region of the brain responsible for specific cognitive functions. Fifteen percent of patients declined across all brain networks the team evaluated.


2 weeks agoHealth / Aging : Time Goes By

This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...

Fight Aging! Newsletter, February 12th 2018

2 weeks agoHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

What Can a Man’s Finger Size Tell you About His Sex Appeal?

When it comes to predicting the sex appeal of a man, new research claims it all boils down to the length of one of his fingers. But is this claim valid?

INTERESTING STUFF – 10 February 2018

2 weeks agoHealth / Aging : Time Goes By

THE OLDEST RESTAURANT IN THE WORLD Botin Restaurant has been open for business every day for the past 293 years. In that time, since 1725, the oven fire has never been extinguished. ”According to deputy manager Luis Javier Sànchez Alvarez,...

A Few Recent Advances in Tissue Engineering and Regenerative Medicine

2 weeks agoHealth / Aging : Fight Aging

The tissue engineering and regenerative medicine communities are too large and energetic to do more than sample their output, or note the most interesting advances that stand out from the pack. The publicity materials I'll point out here are a recent selection of items that caught my eye as they went past. Show More Summary

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