A number of the aspects of Alzheimer's disease biochemistry have a strong similarity to aspects of type 2 diabetes biochemistry. Alzheimer's also has the same risk factors, such as the presence of excess visceral fat tissue. Some researchers have gone so far as to call for the classification of Alzheimer's as type 3 diabetes. Show More Summary
In this open access review paper, the authors make a case for more human trials in the development of stem cell therapies to treat neurodegenerative diseases. An abundance of caution and heavy regulatory burden drives greater use ofShow More Summary
There are two ways to provide evidence for a specific cellular mechanism to cause a specific age-related disease. The first, the better method, is to remove, block, or work around the mechanism, while changing as few other variables as possible. Show More Summary
THE PROBLEM About a month ago, I woke one morning with a mystery malady: randomly placed aches on the front, sides and back of my torso in about half a dozen specific locations which change from day to day. These...
A recent commentary celebrates the granting of an International Classification of Disease (ICD) code to sarcopenia, an important step in the lengthy formal definition of a disease. Sarcopenia is the characteristic age-related decline...Show More Summary
Back in 2015, Elizabeth Parrish underwent telomerase and follistatin gene therapy as a part of forming the startup BioViva: a human safety trial of one person, made public as a way to push the bounds of the current debate over when we should get started on human testing of these technologies. Show More Summary
New research suggests just how early in life the psychopath’s traits can be spotted.
Following the commercial shopping days of Black Friday and Cyber Monday is the day for non-profits and charitable donation, Giving Tuesday. It is a young idea, first announced in 2012, but a great idea, and one that has seen considerable adoption. Show More Summary
It’s well known that people high in narcissism have an endless need to look good. What’s less clear is why. A new study sheds light on why, and how, narcissists seek to seem ideal.
Approximately one third of people with Alzheimer’s disease use prescription medicines for pain after their diagnosis, reports a recent study. The use of analgesics was as common among persons with Alzheimer’s disease as it was among those of the same age without the disease, but there were significant differences in the types of medicines used.
Rates of obesity and high blood pressure, or hypertension, follow the increases in wealth and comfort that have spread through much of the world over the past 60 years. Regions that are in the process of transitioning from predominantly...Show More Summary
Researchers here investigate a class of drug that blocks interleukin-1 receptor activity, something that has been found to reduce cell death and improve regeneration following stroke. This form of interference in cellular metabolismShow More Summary
In the paper I'll point out today, researchers map an efficient form of protein quality control from stem cells and recreate it in somatic cells, producing extended life in nematode worms as a result. Proteins are large, complex molecules,...Show More Summary
With age, somatic cells such as neurons lose their ability to maintain the quality of their protein content. Pluripotent stem cells, on the contrary, do not age and have increased mechanism to maintain the integrity of their proteins. Show More Summary
EDITORIAL NOTE: This is a nuts-and-bolts post pulling together some information we are going to need before long. I know some readers don't want any more politics, but emboldened Republicans are hard bent on killing Medicare and they want to...
The comparative biology of aging and longevity, comparing the biochemistry of similar species with different life spans, is a good way to improve understanding of which aspects of our biology are important determinants of degeneration and age-related disease. Show More Summary
To what degree does regular exercise beyond the recommended minimum of 30 minutes a day improve long-term health and life expectancy? This and related questions on the shape of the dose-response curve for aerobic exercise remain open for debate. Show More Summary
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
We like to think that people can change, but when it comes to psychopathy, those odds seem low. New research suggests just how early in life the psychopath’s traits can be spotted.