There are plenty of results from the past decade to illustrate that the methodology by which a therapy is delivered makes a great deal of difference to the outcome in patients. Here, for example, researchers have found a way to improve the performance of viruses engineered to preferentially target cancer cells. Show More Summary
With age, harmful waste products accumulate in cells as a normal side-effect of cellular processes. Some of these cannot be easily degraded and build up inside the recycling units called lysosomes, especially in the long-lived cells of the nervous system. Show More Summary
There is a month left to go in the SENS crowdfunding campaign that aims to push forward with an important component of a universal cancer therapy, a way to block the mechanisms of telomere lengthening that every type of cancer depends upon. Show More Summary
Researchers suggest, from an examination of epidemiological data, that stroke is for most patients a preventable occurrence largely driven by hypertension, inactivity, and obesity. In this the implication is that better life choicesShow More Summary
The protein gadd45a and its relatives in the same group are involved in many processes relevant to aging, and can be adjusted to modestly extend life in flies. Gadd45a is in particular implicated in muscle atrophy, a process that significantly...Show More Summary
As I set about writing today's post yesterday morning, pulling together notes and links on a health-related story, the teevee news droning in the background interrupted itself with the announcement of shootings in Baton Rouge. It took me a couple...
FIGHT AGING! NEWSLETTER July 18th 2016 Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent...Show More Summary
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
Whether you intend to or not, it’s very easy to get swept into the narcissistic bubble where you feel special and entitled. When that bubble bursts, how will you survive?
SECRETARY CLINTON COMMITS TO EXPANDING SOCIAL SECURITY At their appearance together last Tuesday (which this week feels like a month ago) as Senator Bernie Sanders endorsed Secretary Hillary Clinton for president, she adopted Sanders's position on Social Security. Here's the...
As regular readers will know, I've long considered the cryonics industry to be a sensible, necessary undertaking in an uncertain world. For those of us interested in longevity, the primary plan is to accelerate development of rejuvenation...Show More Summary
As hard as you try, you may find it impossible to get along with certain family members, coworkers, or acquaintances. This simple guide will give you the tricks you need.
Aging came into being very early in the history of life, resulting from the evolution of strategies to deal with the inevitable accumulation of metabolic waste and damaged molecules in single-celled organisms: operating any sort of machinery produces wear and byproducts, and this is just as true of biological machinery. Show More Summary
That headline is what legendary television producer Norman Lear says about ageing. He will be 94 on the 27th of this month, one of the top examples we have right now for fighting entrenched ageism for two reasons: He is...
It is known that the practice of calorie restriction, reducing calorie intake while still obtaining sufficient micronutrients, reduces inflammation in animals. This is one of many beneficial changes in the operation of metabolism observed...Show More Summary
Today I'll point out a brace of recent research materials, all of which focus on the aging brain. A great deal of aging research is focused on the effects of aging in the brain, in part driven by the large level of investment in Alzheimer's...Show More Summary
Without your realizing it, your beliefs about intimacy may be based more on myth than reality.
Researchers here cast doubt on nuclear DNA damage as a primary cause of decline in the stem cells population that is responsible for creating immune cells and blood cells. All cell populations accumulate random mutations in nuclear DNA over the course of aging. Show More Summary
It is known that greater levels of education correlate with greater life expectancy, but the novelty in the research here is a matter of just how far back in history this correlation can be shown to exist - it isn't dependent on access to very modern medicine. Show More Summary
Today I'll point out a great open access paper on the evolution of human telomere dynamics: telomere length, how that length changes over time, and especially how it changes with aging. This makes a good companion piece to another paper from last week that covered the differences in telomere dynamics between mice and humans. Show More Summary