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Betterhumans Aims to Run Senolytic Trials

last weekHealth / Aging : Fight Aging

Some of you may remember Betterhumans as one of a number of transhumanist community websites from years back, providing news and advocacy in service of efforts to improve the human condition. Extending healthy lifespan by engineering practical rejuvenation therapies has always been a core transhumanist goal. Show More Summary

Asking the Wrong Questions about Aging and Disease

last weekHealth / Aging : Fight Aging

Age-related diseases began as a matter of taxonomy. Presented with the immensely complex, mysterious, varied, and inscrutable happenings at the end of life, the first scientists, before science was even much defined, began by trying to categorize their observations. Show More Summary

Follicle-Stimulating Hormone in Long-Lived Mice

last weekHealth / Aging : Fight Aging

It has been quite a number of years since researchers first produced dwarf mice with disabled growth hormone or growth hormone receptors, some of which still hold the record for engineered mouse longevity. Using these mice as a point...Show More Summary

You and Me and Flu Season

EDITORIAL NOTE: Several readers suggested I replace the far right photo in the banner with a screen grab from the video interview I posted on Saturday. I thought that was a pretty good idea, so I did it. See above....

The Circular Relationship Between Senescent Cells and Chronic Kidney Disease

last weekHealth / Aging : Fight Aging

Growth in the number of senescent cells that linger in tissues is one of the root causes of aging. In this context, the open access paper noted here illustrates a couple of points that are worth bearing in mind while thinking about the biochemistry of aging, the first of which is that aging is a feedback loop of damage. Show More Summary

ELDER MUSIC: Classical Gas Part 7

This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...

Fight Aging! Newsletter, September 11th 2017

last weekHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

It's Harder to Spot a Psychopath than You Might Think

The most widely used test to diagnose a psychopath comes under scrutiny in a new analysis of how well psychologists can agree in rating real clinical cases.

INTERESTING STUFF – 9 September 2017

2 weeks agoHealth / Aging : Time Goes By

ALEX BENNETT INTERVIEWS WIFE No. 2: ME From 1965 to 1971, I was married to Alex Bennett, a radio talk show host who now does an interview program on the internet and on Wednesday, he interviewed me. This is a...

More Evidence for Senescent Cell Signaling to be a Cause of Age-Related Fibrosis

2 weeks agoHealth / Aging : Fight Aging

Regeneration and tissue maintenance are highly complex, regulated processes. Unfortunately, these processes run awry as the low-level molecular damage of aging increases over the years. Cells change their behavior, change the signals they produce, and one of the detrimental outcomes of these changes is fibrosis. Show More Summary

Some Advantages of Being Old

2 weeks agoHealth / Aging : Time Goes By

Crabby Old Lady and I have spent a lot of time here in the past couple of months writing about one of the big downsides of old age, serious medical problems. Let's do something different today. Here is a list...

Microbial Theories of Alzheimer's Disease are Gaining Support

2 weeks agoHealth / Aging : Fight Aging

The lack of concrete progress in the amyloid clearance approach to Alzheimer's disease, despite significant investment and many clinical trials over the past decade, has led to a great deal of theorizing in the research community. Is...Show More Summary

Oxidized Dopamine and Dysfunctional Lysosomes in Parkinson's Disease

2 weeks agoHealth / Aging : Fight Aging

This research improves on the established links between a few of the forms of molecular damage and cellular dysfunction that central to the SENS view of aging, at least in the case of Parkinson's disease. These are lysosomal failure,...Show More Summary

A Link Between Mechanisms of Calorie Restriction and Ketogenesis

2 weeks agoHealth / Aging : Fight Aging

Calorie restriction slows aging in most species and lineages tested to date, though the size of the effect on life span diminishes as species life span increases. Calorie restriction produces very similar short-term health benefits in humans and mice, but mice live as much as 40% longer as a result. Show More Summary

Human skin cells transformed directly into motor neurons

Scientists have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state. The technique makes it possible to study motor neurons of the human central nervous system in the lab. Unlike...Show More Summary

Connection between low oxygen levels, human gene discovered

Researchers have established a link between hypoxia, a condition that reduces the flow of oxygen to tissues, and HOTAIR, a noncoding RNA or molecule that has been implicated in several types of cancer.

Biologists slow aging, extend lifespan of fruit flies

In research that potentially could delay the onset of Parkinson's disease, Alzheimer's disease, cancer, stroke, cardiovascular disease, and other diseases of aging, biologists have produced a genetic one-two punch that significantly slowed aging and improved health in the middle-aged fruit flies they studied.

Eat fat, live longer?

As more people live into their 80s and 90s, researchers have delved into the issues of health and quality of life during aging. A recent mouse study sheds light on those questions by demonstrating that a high fat, or ketogenic, diet not only increases longevity, but improves physical strength.

Intermittent electrical brain stimulation improves memory

Intermittent electrical stimulation of an area deep inside the brain that degenerates in Alzheimer's appears to improve working memory, scientists report. Conversely, continuous deep brain stimulation, like the type used for Parkinson's and currently under study in humans with Alzheimer's, impairs memory, according to study.

Gcn4 Slows Aging in Yeast via Reduced Protein Synthesis

2 weeks agoHealth / Aging : Fight Aging

Many methods of modestly slowing aging in laboratory species are accompanied by reduced rates of protein synthesis and higher levels of activity by cellular maintenance processes such as autophagy. The research noted here is one of a...Show More Summary

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