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HIF-1 and AMPK in Regulation of Mitochondrial Generation of Reactive Oxygen Species

2 weeks agoHealth / Aging : Fight Aging

Many of the varied genes and proteins that can be manipulated to extend longevity in lower animals are associated with mitochondrial function, and specifically the pace at which mitochondria generate reactive oxygen species (ROS) inShow More Summary

Enhanced Catalase in the Mitochondria Improves Muscle Function in Aging

2 weeks agoHealth / Aging : Fight Aging

Mitochondria are the cell's power plants, swarming in bacteria-like herds to create chemical energy stores. They bear their own DNA, distinct from that in the cell nucleus. This mitochondrial DNA can become damaged in aging and someShow More Summary

A Mechanism for Calorie Restriction to Reduce Both DNA Damage and Cellular Senescence

2 weeks agoHealth / Aging : Fight Aging

The practice of calorie restriction, consuming fewer calories while still obtaining optimal levels of dietary micronutrients, has been demonstrated to greatly improve measures of health in humans and slow the progress of near every measure of degenerative aging in numerous species in the laboratory. Show More Summary

The Psychology Behind the Crisis-Prone Personality

People who are continually in crisis mode not only lead unhealthy lives but also create havoc for those who know or work with them. Psychology has some answers to help understand what’s behind it all and how to help them live calmer, more even-keeled and ultimately happier lives. read more

Do You Live in a Good Aging-in-Place Community?

2 weeks agoHealth / Aging : Time Goes By

For years in repeated surveys, 89 or 90 percent of people polled say they want to “age in place.” Most frequently, that phrase means they want to stay in the homes where they currently live until they die or, at...

A Look at the Current State of Drug Treatments for Amyloidosis

2 weeks agoHealth / Aging : Fight Aging

Amyloids are formed from handful of types of misfolded proteins that interact to form insoluble deposits in tissues. The presence of amyloid grows with aging, and eventually causes the serious, fatal disruption of tissue function found in the family of amyloidosis conditions. Show More Summary

Female Survival Advantage Diminishes with Age

2 weeks agoHealth / Aging : Fight Aging

Women live longer than men, and while there is no shortage of theories as to why this is the case, the research community has yet to convincingly demonstrate which of them are correct. Adding an additional twist that will need to beShow More Summary

BioWatch News on Rejuvenation Biotechnology 2014

2 weeks agoHealth / Aging : Fight Aging

BioWatch News is a market analysis venture focused on biotechnology, especially medical research and development. This is a fairly common business model: find a niche and help to explain it to investors. People with a lot of money at stake in the market will pay a proportionally greater price for good articles and analysis. Show More Summary

It is Okay to Just Be Old

2 weeks agoHealth / Aging : Time Goes By

For five days last week you, dear readers, wrote this blog by responding to forum topics many of you had already suggested during the previous week. And a fine job you did of it. Lots of interesting opinions, thoughts, ideas...

Blocking Blood Vessel Inflammation to Diminish Atherosclerosis

2 weeks agoHealth / Aging : Fight Aging

Researchers have a found a way to selectively interfere with inflammatory processes in blood vessel walls so as to slow the onset of atherosclerosis: Normally, the lining of blood vessels, or endothelium [ignores] the many cells and other factors rushing by in the bloodstream. Show More Summary

A Look at Various Approaches to Prosthetic Vision

2 weeks agoHealth / Aging : Fight Aging

Artificial vision for the blind lies ahead, and this research and development proceeds in competition with regeneration medicine approaches that aim to reverse degeneration and damage in the eye. Some of the most advanced prototype devices...Show More Summary

Are You the Inspirational Type?

In a world full of inspirational quotes, it might seem that we're all looking for ways to become more motivated. As it turns out, some of us are more likely to get inspired than others. This 4-item test will show where you stand on the inspirational scale, and how becoming inspired can help you achieve your goals. read more

INTERESTING STUFF – 4 October 2014

2 weeks agoHealth / Aging : Time Goes By

FROM BIRTH TO AGE 80 IN FOUR MINUTES Age progression videos are always fun to watch. This one, a “live” painting, is by South Korean illustrator Seok Jeong-hyeon. THE ART OF THE OBIT For nearly 20 years, Margalit Fox has...

You Speak to the Audience You Have

2 weeks agoHealth / Aging : Fight Aging

Steve Aoki is a successful musician, but also, of late at least, an advocate for transhumanist goals for the near future that include rejuvenation research after the SENS model. This scientific paradigm is a path towards radical life...Show More Summary

TGB FORUM: Readers Write the Blog – Day 5

3 weeks agoHealth / Aging : Time Goes By

As I explained on Monday, while Peter Tibbles and Norma Gates are visiting from Melbourne, I am taking a mini-vacation and letting you, dear readers, write the blog based on your own topics. Today's comes from doctafil with so many....

Young Cognitive Function Predicts Aged Pulmonary Function

3 weeks agoHealth / Aging : Fight Aging

Many measurable differences in human ability and life course correlate with long-term health, age-related dysfunction, and mortality. Intelligence, social standing, and wealth are some of the more easily measured line items, but the reasons why these things correlate with better health and life expectancy remain to be proven. Show More Summary

Proposing Heterochronic Parabiosis as a Way to Win Half of the Palo Alto Longevity Prize

3 weeks agoHealth / Aging : Fight Aging

The recently announced Palo Alto Longevity Prize is split into two parts, with the second to be awarded for a demonstration that restores metabolic homeostasis in an aging mammal to that of a young mammal. The prize administrators picked heart rate variability as the surrogate measure of homeostasis, which is an interesting choice. Show More Summary

A Little Reverse Engineering of the Role of Inflammation in Age-Related Immune Dysfunction

3 weeks agoHealth / Aging : Fight Aging

Short term inflammation is a vital part of the immune response, necessary to keep us healthy in the face of life's many slings and arrows. Chronic inflammation is a different story, however, as it is a potent source of damage to tissues and bodily systems over the course of a lifetime. Show More Summary

The "Slow Aging with Drugs" Viewpoint

3 weeks agoHealth / Aging : Fight Aging

Most of that portion of the aging research community interested in intervening in the aging process to extend healthy life focus on near term drug discovery and reuse. They recognize that the gains here will be small and the process, like all drug development, will be enormously expensive. Show More Summary

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