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A Focus on NLRP3 in Inflammatory and Age-Related Disease

last weekHealth / Aging : Fight Aging

Raised levels of chronic inflammation play an important role in degenerative aging, as well as in many medical conditions. Much of this inflammation in aging is driven by systemic changes, as it is very similar in every individual: it...Show More Summary

Advanced Glycation End-Products in Neurodegenerative Disease

last weekHealth / Aging : Fight Aging

Advanced glycation end-products (AGEs) of various types are both generated in the body and arrive via the diet. Some are short-lived and easily broken down, but still a problem in people with abnormal metabolisms, such as diabetics,Show More Summary

A Speculative Example of Slowing Aging via Plasma Transfer

last weekHealth / Aging : Fight Aging

As a result of parabiosis research there is presently some interest in exploring transfer of blood from young donors and direct alteration of levels of circulating proteins to try to impact the progression of aging in the old. Making...Show More Summary

On Aging by Maya Angelou

In between naps last week during the several days' recovery following my dental surgery, I read. Not any of the several books I am currently working through – I didn't think I would have much recall, given the effects of...

SENS Research Foundation Newsletter, February 2015

last weekHealth / Aging : Fight Aging

The SENS Research Foundation coordinates fundamental research into the technologies needed for future rejuvenation treatments. There is in fact a very clear roadmap leading from where we are today to the means to repair the cellular and molecular damage that causes aging. Show More Summary

ELDER MUSIC: 1970 Again

This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...

INTERESTING STUFF – 14 February 2015

2 weeks agoHealth / Aging : Time Goes By

HAPPY VALENTINE'S DAY EVERYONE I completely missed Valentines Day until I had finished writing today's Interesting Stuff but I caught myself. So here is a holiday ditty - well-suited to such a blog as this - from Henry Lowenstern wh...

5 Ways to Get Your Unwanted Emotions Under Control

Being able to control your emotions is key to your happiness as well as your relationships. With these 5 strategies, you’ll be able to feel better and react more effectively to challenges both large and small.

Targeting Interleukin-10 to Spur Immune Cells into Clearing Amyloid From the Brain

2 weeks agoHealth / Aging : Fight Aging

The immune system incorporates a large number of very sophisticated mechanisms for clearing debris, killing errant cells and pathogens, and removing unwanted metabolic waste. Therefore many research groups aim to harness and steer immune...Show More Summary

The Prospect of Using Antioxidants to Suppress Damage Following Stroke or Other Brain Injury

2 weeks agoHealth / Aging : Fight Aging

Much of the damage done following an ischemic stroke occurs when blood flow returns: there is a sudden and overwhelming production of reactive molecules and cells die as a result. Given sufficiently potent and safe antioxidants, this...Show More Summary

Dental Week Departures

2 weeks agoHealth / Aging : Time Goes By

Dear god. I take a couple of days off and a large chunk of my personal media landscape decamps from the scene. BRIAN WILLIAMS NBC Nightly News anchor Brian Williams was suspended without pay for six months for inflating his...

Killifish as a Platform for the Study of the Biochemistry of Aging

2 weeks agoHealth / Aging : Fight Aging

There are many trade-offs to be made in aging research, and most of them involve the balance between expended resources and time on the one hand and the expectation value of knowledge gained on the other. The challenge inherent in the...Show More Summary

Ongoing Recovery From Dental Implants

2 weeks agoHealth / Aging : Time Goes By

Thank you all for your kind words yesterday. One thing: I'm as dentist-phobic as all the rest of you but it's not like I had a choice. Well, except for walking around toothless which I didn't see as an option....

Proposing Dialysis-Like Blood Filtration and Augmentation in Order to Slow Aging

2 weeks agoHealth / Aging : Fight Aging

Parabiosis research in which the circulatory systems of a young and old mouse are connected has led to a cataloging of differences in circulating factors in old versus young blood. Researchers have demonstrated that resetting the levels...Show More Summary

Mitochondrial and Cytoplasmic Oxidative Stress Have Opposing Effects on Lifespan in Nematode Worms

2 weeks agoHealth / Aging : Fight Aging

Oxidative stress refers to higher levels of oxidizing molecules present in and around cells, causing more damage by reacting with protein machinery that must then be repaired. Work over the past two decades has show that raising or lowering...Show More Summary

Comparing Aging and Chronic Kidney Disease

2 weeks agoHealth / Aging : Fight Aging

Chronic kidney disease (CKD) is a particular unpleasant condition, not least because it accelerates many of the other manifestations of aging, but also because there is comparatively little that can be done to treat it at this time.Show More Summary

Oops – Out of Commission Today

2 weeks agoHealth / Aging : Time Goes By

Sorry there is no post today. I neglected to work ahead this time and, more particularly, I miscalculated how tired I would feel after two-hours of dental surgery yesterday morning for a bunch of implants. I'll be back tomorrow or,....

Towards Eternal Youth For All

2 weeks agoHealth / Aging : Fight Aging

The progression of degenerative aging is presently the greatest cause of pain and suffering in the world, so why are we not all greatly in favor of working towards medical technologies capable of preventing the detrimental results of...Show More Summary

The Intricate Interplay of Aging and Cancer

2 weeks agoHealth / Aging : Fight Aging

Aging and cancer have evolved hand in hand, and numerous aspects of our biology play an important role in both. At the simplest, highest level we have things like the decline in stem cell activity and tissue maintenance with age as a...Show More Summary

Disappointing Comments on Longevity Science From Bill Gates

2 weeks agoHealth / Aging : Fight Aging

In a recent Reddit discussion, philanthropist Bill Gates had this to say about the present growth in research aimed at extending healthy life spans: It seems pretty egocentric while we still have malaria and TB for rich people to fund things so they can live longer. Show More Summary

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