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An Interview with Ilia Stambler on the History and Future of Longevity Science

last weekHealth / Aging : Fight Aging

Ilia Stambler is, I think, perhaps the foremost historian in our longevity science community at this time. That position was earned by setting forth to do the hard work of assembling a history of advocacy and efforts to extend healthy life spans. Show More Summary

Reduced Efr3a Promotes Neurogenesis in the Hippocampus

last weekHealth / Aging : Fight Aging

The brain generates new cells at a fairly sedate pace in the process known as neurogenesis, slowly integrating newly created cells into existing neural circuits. This enables some modest degree of repair of damage, but also appears to be important in the normal operation of the mind. Show More Summary

Interleukin-7 and Immunosenescence

last weekHealth / Aging : Fight Aging

Researchers here examine what is known of the role of interleukin-7 (IL-7) in the gradual decline and malfunction of the aging immune system. In the old, the immune system is both more active, producing chronic inflammation that drives...Show More Summary

The Importance of the Comey Firing

If, earlier this week, the friend to whom I said I believe the U.S. is in the midst of a slow-moving coup had called me out for being hyperbolic, I would not have disagreed. That is, until I ran across...

Increased Adenosine Slows Cartilage Degeneration in Osteoarthritis

last weekHealth / Aging : Fight Aging

All age-related diseases are complex enough to have many facets through which they can be viewed, each facet being just one stage or one contributing cause, or one viewpoint on the disease process as a whole. An entire ecosystem of theory and potential therapies can be built within one facet without ever having to consider other mechanisms. Show More Summary

The Aging of Lymphatic Vessels

last weekHealth / Aging : Fight Aging

All of the the body's systems are impacted by aging. Damage to cells and tissues occurs as a consequences of the normal operation of metabolism, and leads to a chain of cause and consequence that ultimately produces functional declines and age-related disease. Show More Summary

Exercise Correlates with Longer Average Telomere Length

last weekHealth / Aging : Fight Aging

Average telomere length as presently measured in white blood cells is a terrible measure of biological age. The pattern of decreasing length over time only shows up in statistical data over large populations, and even then you'll find studies in which this doesn't happen. Show More Summary

Confirming Age-Associated B Cells as an Important Cause of Autoimmunity

last weekHealth / Aging : Fight Aging

Most of the better known and more common forms of autoimmune disease are not all that age-related, though incidence for many of them ticks upwards with age as the immune system becomes ever more dysfunctional in later life. There are...Show More Summary

Thioredoxin Reductase Correlates with Species Longevity

2 weeks agoHealth / Aging : Fight Aging

Researchers here summarize current data on thioredoxin reductase and longevity across a range of species, finding a correlation for the mitochondrial variant of this protein. There are numerous proteins for which one can point to correlations...Show More Summary

An Exploration of Mechanisms of Hair Greying, but not Yet Linked to Aging

2 weeks agoHealth / Aging : Fight Aging

This research is an example of the way in which both the mainstream press and research publicity materials are sometimes quite terrible. The researchers involved have explored some of the cellular biochemistry that is necessary to the pigmentation of hair. Show More Summary

Sex and Old People

2 weeks agoHealth / Aging : Time Goes By

On Monday we talked about language, certain words that are offensive to some people, so why not move right along to talking about sex today, elder sex, and see how it goes. When I began this blog in 2004, the...

The Best Way to Satisfy a Narcissist's Need for Pride

Pride is one of those double-edged emotional swords that can go before your downfall or help you achieve your goals. New research shows when it’s most likely to help, not hurt.

There's a Fine Line Between Pride and Narcissism

Pride is one of those double-edged emotional swords that can go before your downfall or help you achieve your goals. New research shows when it’s most likely to help, not hurt.

Enhanced Autophagy as a Potential Basis for Treating Neurodegenerative Conditions

2 weeks agoHealth / Aging : Fight Aging

The consensus in the scientific community is that useful therapies can be built on the safe enhancement of autophagy. This has been the case for many years now, but unfortunately, and despite a broad and ongoing range of research initiatives, there has yet to be any significant progress on the path from laboratory to clinic in this part of the field. Show More Summary

The Mistaken Belief that Rejuvenation Therapies Will Not Arrive in our Lifetimes

2 weeks agoHealth / Aging : Fight Aging

If you ask those who are skeptical, disinterested, or even hostile towards work on the basis for rejuvenation therapies, many of them justify their positions with - among other items - a belief that rejuvenation is a far future possibility, not something that will arrive in their lifetimes. Show More Summary

Cannabinoid Metabolism and Age-Related Memory Decline

2 weeks agoHealth / Aging : Fight Aging

Researchers here demonstrate a role for cannaboids in the age-related decline of memory function. Levels of natural cannaboids decline with aging, and the researchers provide evidence for this to be a proximate cause of the loss of memory function in later life. Show More Summary

Fight Aging! Invests in the Methuselah Fund

2 weeks agoHealth / Aging : Fight Aging

As you might recall, the Methuselah Foundation recently formalized its years of non-profit activities as an incubator of biotechnology startups to launch the Methuselah Fund. The goal remains the same: to accelerate the development of rejuvenation biotechnology by funding promising young companies in important areas of medicine. Show More Summary

Prevention of Stroke and Prevention of Dementia Overlap

2 weeks agoHealth / Aging : Fight Aging

Aging is a process in which a smaller number of mechanisms produce a larger range of consequences. This is true at the start of the chain of cause and effect, in which cell and tissue damage outlined in the SENS rejuvenation research programs produces a large range of secondary dysfunctions. Show More Summary

Towards a Soft Synthetic Retina

2 weeks agoHealth / Aging : Fight Aging

Researchers have made the first steps towards generating a soft synthetic replacement for the retina that is capable of generating electrical signals in response to light. A great deal of work is yet to be accomplished in order to turn...Show More Summary

Profanity and Crabby Old Lady

2 weeks agoHealth / Aging : Time Goes By

EDITORIAL NOTE: Ted Carr, who worked in the tech industry during some its most exciting years, retired about six years ago. He now hosts a podcast called Retirement Journeys – Real-Life Experience that Informs, Engages and Inspires and in February,...

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