There is comparatively little study of sirtuin 7 (SIRT7) in comparison to the better known and greatly overhyped sirtuin 1 (SIRT1). All members of the sirtuin family have broad influence over a range of fundamental cellular processes,...Show More Summary
A broad range of methods are under development to engineer T cells that can selectively attack cancer cells. If aggressive enough and selective enough, the immune system should in theory be able to tame and destroy most cancers, but the devil is in the details as is always the case in these matters. Show More Summary
The first practical outcome of tissue engineering research is not therapies, but rather improved tools for further scientific work in this and other fields. At present the structured tissue sections created in the laboratory are largely...Show More Summary
The most prevalent causes of blindness are degenerative and associated with aging, the result of loss of cells and structure in the retina. There are numerous other causes, including optic nerve damage that can result from trauma, but these are fortunately less common. Show More Summary
One of the good things the ageing of the huge baby boomer generation has spawned is an upsurge in research about old people, particularly brain and cognition research, and I follow it closely. Well, as much as possible. Most study.....
Researchers have discovered a novel approach to spur greater regeneration in heart tissue: The heart tissue of mammals has limited capacity to regenerate after an injury such as a heart attack, in part due to the inability to reactivate a cardiac muscle cell and proliferation program. Show More Summary
It is perfectly possible to build a tremendously successful business while failing to deliver on any of the initial motivating goals and ideals. The modern "anti-aging" industry is a perfect example of this point, written thousands of times over in the careers of salespeople and founders. Show More Summary
When public figures erroneously report on events that didn’t actually happen in their lives, the whole world knows about it. However, false memories are a common occurrence in everyone’s day-to-day thinking. Remembering what you want to remember may be more a matter of identity than of failing memory.
There are a surprisingly large number of studies on personality traits and psychological states as they relate to health status in aging. I can't help but feel that all those funds should perhaps have gone towards generating more practical outcomes in the sciences, but it is what it is. Show More Summary
On Monday's post about Donald Hall's Essays at Eighty, Crabby Old Lady made particular note of a couple of readers who picked up and ran with the poet's thought about what bores him: ”You know what I find boring?” commented...
Calorie restriction mimetic treatments are those that recreate at least some part of the calorie restriction response. Calorie restriction with optimal nutrition alters near every measure of metabolism and slows near every measure of...Show More Summary
Research institutions are willing to pour comparatively large sums into the pursuit of existing already developed and approved drugs that might, possibly, have some marginal, tiny effect on the course of degenerative aging. This is one...Show More Summary
It’s becoming socially more acceptable to admit to finding a mate online, but there remain many misconceptions about online dating. Find out your online dating IQ with this 8-item quiz that separates myth from reality.
It’s becoming socially more acceptable to admit to finding a mate online, but there remain many misconceptions about online dating. Find out what you know, and don't know, about online dating sites with this 8-item true-false quiz.
Mitochondria, the power plants of the cell, are important in aging. They are the descendants of symbiotic bacteria and contain their own DNA, separate from that in the cell nucleus. This mitochondrial DNA is just a remnant, however, as over the course of evolutionary time most of its genes have moved to the nucleus. Show More Summary
The brain is impacted by the processes of degenerative aging for decades before the damage rises to noticeable levels. When the technologies exist to repair this damage, treatments should ideally begin in the middle of life, not wait until there are obvious signs of degeneration. Show More Summary
About ten days ago, I wrote about being so forgetful now that I had gone to the store with only one item in mind and got home with six other things but not the apples I intended. According to the...
Scientist and advocate Aubrey de Grey is the co-founder of the SENS Research Foundation, one of the most important organizations in aging research today, given its goal of turning the focus of the scientific community towards the implementation of rejuvenation biotechnology. Show More Summary
Autophagy is one of the housekeeping processes responsible for recycling damaged mechanisms and structures in cells before they can cause further harm. A type of organelle called the lysosome performs the recycling, but lysosomal activity...Show More Summary
Investor and philanthropist Peter Thiel has given millions to support the rejuvenation biotechnology research programs funded by the SENS Research Foundation and Methuselah Foundation before it. He was one of the first wealthy individuals...Show More Summary