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At age 74, I am healthy, happy enough and curious about what each new day might bring. I am also grateful that I live in one of five U.S. states that allows physician-assisted suicide. It's not something I dwell on...
Here I'll point out a recent update on one line of targeted cancer therapies presently under development. These forms of treatment will ultimately replace the much less discriminating therapies of today, and will be used to control and clear cancers with few side-effects for the patient. Show More Summary
The changes involved in producing induced pluripotent stem cells from ordinary somatic cells, such as those from a skin sample, are accompanied by mitochondrial rejuvenation, a clearance of mitochondrial damage associated with aging....Show More Summary
Here I'll point out a couple of recent research publications on the topic of blood pressure in aging. Blood pressure is an useful metric in the progression of aging, not least because it can be cheaply and reliably measured. It is also...Show More Summary
It is interesting to see more researchers willing to place timelines on the regeneration or tissue engineering of replacement limbs, as is the case here. It is a sign of confidence and progress in the foundations of the field. So far...Show More Summary
Tissue engineers cannot yet construct sufficiently complex extracellular matrix structures with the correct mechanical and other properties to support the growth of entire organs from scratch. This is why the use of decellularized organs...Show More Summary
We know the long-term care (LTC) insurance industry wants to storm America with its expensive and nebulous products, but few "experts" present a complete picture: the economic downsides of LTC insurance, the alternatives, and the possibilities for better insurance products in the future. Show More Summary
Today I'll point out an interesting open access paper in which the authors discuss what is probably an aspect of the observation that greater proteostasis correlates with greater longevity. Proteostasis is just a fancy way of sayingShow More Summary
Every day alarms are raised about the the burdens old people place on society. The growing “silver tsunami” will make life awful for everyone else we are told. From government to employment to media and more, the conventional wisdom is...
Filtration in biology is a tractable problem to solve, to build devices that can carry out at least part of the function of organs like the kidneys by removing unwanted substances from the blood. There are already numerous fairly effective means of carrying out dialysis outside the body, for example. Show More Summary
The use of pigs to expand the supply of donor organs for human patients is coming closer to reality. A number of new technologies are enabling researchers to remove the various blocking issues in cross-species transplantation: cheap and efficient gene therapy, decellularization, and so forth. Show More Summary
A group of UK researchers have recently banded together to coordinate research into cryonics and cryobiology, the low-temperature preservation of tissues. Only small collections of cells can presently be reversibly cryopreserved, but there is a strong incentive to build the means to reversibly preserve whole organs and other large tissue structures. Show More Summary
For most of us, there’s plenty to worry about in our lives. However, some people seem to figure out how to keep their worries down to a minimum. Whether you’re a chronic or sometime worrier, you can benefit from learning their secre...
Wnt signaling has long been investigated in connection with the processes of adult regeneration and embryonic development. This latest news notes progress towards a class of therapies that inhibit the Wnt pathway, potentially producing...Show More Summary
Exercise is known to improve health and modestly slow the progression of age-related degeneration. Here is one example of numerous ongoing research programs that seek to define the effects of exercise on specific aspects of the aging...Show More Summary
Here I'll point out a recent popular science article on the mechanisms underlying the correlation between cancer and obesity. It is well known and well proven by the scientific community that being overweight is bad for you, even if large sections of the public appear to be solidly in a state of denial on this topic. Show More Summary
As you know, there is no cost-of-living-adjustment (COLA) for Social Security recipients in 2016. It is only the third time in 40 years that this has happened and when you recall that 47% of unmarried recipients and 22% of married.....
Researchers are working on the assessment of patterns of autoantibodies in the blood as a way to determine progression towards Alzheimer's disease and other age-related conditions. The levels of these autoantibodies appear to reflect...Show More Summary
Researchers find an association between reduced mortality and increased daily walking distance in a long-term study that used pedometers to measure participant activity. The 10,000 steps mentioned as a reference point sums to about five...Show More Summary