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The Trans-NIH Geroscience Interest Group

last weekHealth / Aging : Fight Aging

One of the active formal networks for scientists interested in treating aging as a medical condition is the Trans-NIH Geroscience Interest Group (GSIG), with a focus on public funded research and research groups. The thrust of theirShow More Summary

Digging in to the Mechanisms of A2E in Macular Degeneration

last weekHealth / Aging : Fight Aging

An accumulation of the metabolic waste compound A2E in the retina is associated with the progression of degenerative blindness via conditions such as macular degeneration, and there is strong indirect evidence for it to be a cause of the condition. Show More Summary

Functional Tooth Regrowth Demonstrated in a Canine Model

last weekHealth / Aging : Fight Aging

There has been considerable progress over the past decade towards the regrowth or tissue engineering of adult teeth via a number of different mechanisms. These include growing a tooth entirely outside the body, from a few cells, an approach that has a range of associated challenges regarding how to guide the growing tissues to form the right shape. Show More Summary

When Your Whole World Feels Empty

Fairly regularly, we discuss loneliness at this blog mainly due to the oft-repeated cultural belief that all old people who live alone are lonely. The general media pick up this idea from startling research reports that loneliness in elders leads...

A Tour of Some of the Molecular Damage Involved in Aging

last weekHealth / Aging : Fight Aging

The intricate molecular machinery found in cells only functions correctly when it is undamaged, meaning formed of the right atoms and bonds, and that often sizable structure correctly arranged into a particular three-dimensional shape. Show More Summary

A High Level View of Senescent Cell Clearance

last weekHealth / Aging : Fight Aging

This is a better than average popular science article on turning back the progression of aging by removing senescent cells from aged tissues; certainly the bar for article quality set by the mainstream press isn't high, but it is always pleasant to see more authors clearing it. Show More Summary

Fight Aging! Newsletter, March 20th 2017

last weekHealth / Aging : Fight Aging

Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and...Show More Summary

ELDER MUSIC: More Hooked on Classics

This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...


IMPEACHABLE Remember the music group, Peter, Paul and Mary? They were important protest singers back in the Sixties. Now, Peter Tibbles, who writes the Sunday music column here, has forwarded a new song from Noel Paul Stookey. Stookey's musical colleague,...

More on PCSK9 Inhibition to Dramatically Reduce Cholesterol Levels, Lowering the Risk of Later Cardiovascular Disease

last weekHealth / Aging : Fight Aging

There is good evidence for at least some methods of achieving dramatic reductions in blood cholesterol in humans to be safe and reduce the risk of age-related cardiovascular issues. To pick one of the underlying mechanisms involved in...Show More Summary

Indigenous South American group has healthiest arteries of all populations yet studied, providing clues to healthy lifestyle

An 80 year old from the Tsimane (pronounced chee-MAH-nay) group had the same vascular age as an American in their mid-fifties, suggests a new report. The Tsimane people -- a forager-horticulturalist population of the Bolivian AmazonShow More Summary

Keeping the elderly safe

A research team has studied the effectiveness of tailored physical therapy programs for the elderly to prevent falls, also known as the Steps to Avoid Falls in Elderly (SAFE) study.

Novel ICU delirium severity assessment tool developed

A novel easy-to-administer tool to score and track delirium severity in the ICU has been developed and validated, enabling clinicians to make better decisions about the brain health of ICU patients. Scales currently used in the ICU tell clinician if patient is experiencing delirium or not. Show More Summary

The Influence of Children on Late Life Mortality in Humans

last weekHealth / Aging : Fight Aging

Researchers here examine mortality data from one of the wealthier parts of the world, where more people have chosen not to have children, and thus there is a large enough data set to make useful comparisons between older people with and without children. Show More Summary

What Trumpcare Tells Us About Social Security

If you want to know what the Republicans in Congress will soon try to do to Social Security, pay attention to today's post. As we have discussed in these pages many times over the years, Republicans have wanted to kill...

Stochastic Nuclear DNA Damage in Aging

last weekHealth / Aging : Fight Aging

Nuclear DNA in every cell accumulates random mutational errors over time. DNA repair mechanisms are highly efficient, but nonetheless, some damage slips through. It is still an open question as to whether this damage is important over the course of the present human life span, at least beyond the matter of cancer risk. Show More Summary

Can Pregnancy Effects be Used to Argue For Changes in Cell Signaling as an Effective Approach to Treating Aging?

last weekHealth / Aging : Fight Aging

Over the past decade, a few research groups have provided evidence to suggest that pregnancy can enhance regeneration in the mother. The proposed mechanisms have largely involved capable stem cells from the fetus acting as a mild form of stem cell therapy when they find their way into the mother's tissues. Show More Summary

Trials of Autophagy Enhancement to Treat Parkinson's Disease

last weekHealth / Aging : Fight Aging

Researchers are planning trials of a repurposed drug in order to test the effectiveness of enhanced autophagy to treat Parkinson's disease, a condition characterized by loss of the small population of dopaminergenic neurons in the brain. Show More Summary

RNA Interference as a Treatment for Transthyretin Amyloidosis

last weekHealth / Aging : Fight Aging

In this paper, the authors discuss RNA interference (RNAi) as the basis for therapies to treat

Failure of Mitophagy and Mitochondrial Function in Kidney Disease

last weekHealth / Aging : Fight Aging

We modern humans are comparatively lightly affected when it comes to kidney failure as an age-related cause of death; it ranks fairly low in the list. We are primarily killed by cardiovascular issues and cancer. In some other species,...Show More Summary

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