The research noted here is a good example here of inventively combining presently available technologies to achieve a positive result. The scientists involved have demonstrated a way to work around paralysis following spinal cord injury to allow physical activity. Show More Summary
Results were recently published for the first trial of CPHPC as a therapy to clear out age-related deposits of the type of amyloid formed from misfolded transthyretin, normally responsible for transporting the thyroid hormone thyroxine in blood and cerebrospinal fluid. Show More Summary
Stem cell activity declines with age, resulting in increased tissue frailty and dysfunction. Researchers are finding a variety of ways to increase the activity of old stem cell populations, with most of this work focusing on the better known and characterized muscle and bone marrow stem cells. Show More Summary
Researchers can measure the level of noise in the signals of neural circuits in the brain, and see that it is higher in older brains. The proximate cause of this noise is an open question. With an eye to finding out more about the mechanisms...Show More Summary
...that is, the beginning of autumn today. And welcome again to the annual Time Goes By falls prevention blog post. I know I bang on about this, but it is important, crucial even, and besides, if I don't do it...
Researchers have recently demonstrated in pigs the integration of an engineered kidney organoid, a few centimeters of kidney tissue grown from stem cells. The tissue functions as a kidney should, but it is far from full size, and does not bear all of the hallmarks of the real thing. Show More Summary
We know that the quality of a couple’s relationship influences each partner’s satisfaction, and that the quality of sleep influences feelings of an individual’s well-being. It turns out that your satisfaction with your relationship, combined with features of your personality, may actually affect the timing of your and your partner’s sleep-wake cycles during the night.
Here researchers construct a model to try to identify the precise mechanisms by which the buildup of 7-ketocholesterol (7KCh) in cells with age contributes to the development of macular degeneration. 7-ketocholesterol is one of the forms...Show More Summary
The tight junctions between cells of the blood brain barrier are a part of the system controlling passage of molecules between the blood system and brain tissue. They appear to change and fail with age, and this may be one of the ways in which ongoing clearance of amyloid-? falters, allowing the buildup of amyloid associated with Alzheimer's disease. Show More Summary
Today an update on the MitoSENS mitochondrial repair project showcased at the Lifespan.io crowdfunding site: after a few weeks of publicity, more than 200 backers have pledged more than $20,000 of the original $30,000 goal. Congratulations are due the Lifespan.io team and their supporters on the progress to date. Show More Summary
We know that people high on psychopathy and related traits lurk in the “dark side” of personality, but what about its opposite? Having a “bright side” to your personality may sound positive, but it can create its own shadows in your life. See how you rate on these 13 typical qualities of the colorful (but still dark) personality.
This article looks at a few recent papers providing initial evidence for nuclear pore dysfunction to be a important contributing cause of at least some forms of Amyotrophic lateral sclerosis (ALS). This is perhaps of general interest...Show More Summary
The use of carefully structured scaffolds to guide tissue regrowth where it would not normally happen shows considerable promise as an approach to regenerative medicine. Here is a recent example of the state of the art for nerve regrowth: Nerve regeneration is a complex process. Show More Summary
One of the most important people in the ageing “business” is Joseph F. Coughlin. He is the founder and director of the MIT Age Lab in Cambridge, Massachusetts, that since 1999 has been working to improve the quality of life...
This Sunday Elder Music column was launched in December of 2008. By May of the following year, one commenter, Peter Tibbles, had added so much knowledge and value to my poor attempts at musical presentations that I asked him to...
When something goes wrong in your life, is your first reaction to blame someone else? If so, you’re engaging in the very common behavior of the blame game. Unfortunately, there are no winners in this game, so knowing the 5 reasons for why you do this will benefit your relationships.
WHAT RONALD REAGAN REALLY SAID The bazillion Republican presidential candidates are tripping all over themselves trying to be “Reaganesque” when in truth, as my friend Jim Stone emailed, they apparently know little about him. Take a look: Nicely done. REASONS...
Here I'll point out a recent review of approaches to treat one of the more common synucleinopathies, conditions related to - and thought to be caused by - the abnormal accumulation of ?-synuclein in tissues. The pathologies of numerous...Show More Summary
The stiffening of blood vessels due to cross-linking in the extracellular matrix and other factors such as calcification is known to cause hypertension, and the elevated blood pressure of hypertension causes progressive damage to brain tissue. Show More Summary
In this research, partly funded by the SENS Research Foundation, the authors investigate improvements to one type of immunotherapy aimed at clearance of amyloid. Amyloids of numerous types build up in tissues with aging to cause harm...Show More Summary