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Factor that doubles the risk of death from breast cancer identified

Researchers have discovered that the risk of death from breast cancer is twice as high for patients with high heterogeneity of the estrogen receptor within the same tumor as compared to patients with low heterogeneity. The study shows that the higher risk of death is independent of other known tumor markers and also holds true for Luminal A breast cancer.

Creation of synthetic horsepox virus could lead to more effective smallpox vaccine

Researchers created a new synthetic virus that could lead to the development of a more effective vaccine against smallpox. The discovery demonstrates how techniques based on the use of synthetic DNA can be used to advance public health measures.

Can mice really mirror humans when it comes to cancer?

A new study is helping to answer a pressing question among scientists of just how close mice are to people when it comes to researching cancer. The findings reveal how mice can actually mimic human breast cancer tissue and its genes, even more so than previously thought, as well as other cancers including lung, oral and esophagus.

New method to stop cells dividing could help fight cancer

Researchers have used a new strategy to shut down specific enzymes to stop cells from dividing. The method can be used as a strategy to fight cancer.

MIT Portugal is developing a Compression sleeve for breast cancer patients

(MIT Portugal Program) The project developed by the MIT Portugal PhD Student at the University of Minho Carlos Gonçalves, was considered the most innovative of the 9 projects incubated during 10 weeks by Startup Nano, a pioneer incubation...Show More Summary

New gene variant linked to deadly prostate cancer

Researchers have confirmed for the first time a mechanistic link between the gene HSD17B4 and deadly, treatment-resistant prostate cancer. The research shows that men who lack a certain subtype of the gene may be more susceptible to aggressive prostate cancer that does not respond to treatment.

CancerSEEK: Generalized screening for multiple cancer types

(American Association for the Advancement of Science) Researchers have developed a noninvasive blood test based on combined analysis of DNA and proteins that may allow earlier detection of eight common cancer types. In more than 1,000 patients, their method, dubbed CancerSEEK, detected cancer with a sensitivity of 69 to 98 percent (depending on cancer type).

Scientists identify potential target genes to halt progression of thyroid cancer

(Fundação de Amparo à Pesquisa do Estado de São Paulo) Research shows that expression of 52 microRNAs falls as the disease becomes more aggressive. Restoring levels of these molecules in the tumor could be a novel therapeutic strate...

Distorted view amongst smokers of when deadly damage caused by smoking will occur

Smokers have a distorted perception on when the onset of smoking-related conditions will occur, according to a new study.

New drug combination helps kickstart the immune system to fight back against cancer

(King's College London) Scientists from King's College London have found a way to boost the immune system to help it fight back against cancer. The breakthrough involves the first ever use of a combination of chemotherapy and a drug being trialed as a treatment for neonatal jaundice, that together help kick start the body's natural defenses.

Presurgical targeted therapy delays relapse of high-risk stage 3 melanoma

(University of Texas M. D. Anderson Cancer Center) A pair of targeted therapies given before and after surgery for melanoma produced at least a six-fold increase in time to progression compared to standard-of-care surgery for patients with stage 3 disease, researchers at The University of Texas MD Anderson Cancer Center report in Lancet Oncology. Show More Summary

Patients with blood cancer precursor at risk of developing cancer even after 30 years

(Mayo Clinic) Patients with monoclonal gammopathy of undetermined significance are at risk of progressing to multiple myeloma or a related cancer -- even after 30 years of stability. These are the findings of a study by Mayo Clinic researchers published in the Wednesday, Jan. 17, issue of the New England Journal of Medicine.

Mammogram rates increase after ACA eliminates co-payments

(Brown University) A new study finds that screening mammogram rates increased after the Affordable Care Act eliminated out-of-pocket costs.

New way to target the growth of breast cancer cells

Researchers have found a new way of halting the growth of breast cancer cells. The researchers explored a new way to starve cancer cells from their molecular energy source. They hope that their discoveries can be further developed into a new way of treating breast cancer, and possibly other types of cancer.

Normal tissue BRCA1 methylation associated with risk for high-grade ovarian cancer

Normal tissue BRCA1 methylation is associated with risk for high-grade ovarian cancer and may occur as a prenatal event.

Modular gene enhancer promotes leukemia and regulates effectiveness of chemotherapy

Every day, billions of new blood cells are generated in the bone marrow. The gene Myc is known to play an important role in this process, and is also known to play a role in cancer. Scientists have now found that just how big a role Myc plays is determined by a distant section of DNA that contains a cluster of gene enhancers.

Novel precision medicine trial for metastatic pancreatic cancer

(Columbia University Medical Center) The Lustgarten Foundation has awarded Columbia University's Herbert Irving Comprehensive Cancer Center (HICCC) a three-year grant, as part of its Translational Clinical Program, to test a new precision medicine approach to the treatment of metastatic pancreatic cancer.

Review examines the pros and cons of surgery to reduce the risk of cancer

(Wiley) Genetic testing is commonplace for many inheritable cancer syndromes, and with that comes the knowledge of being a gene carrier for some patients. Many guidelines recommend that gene carriers take certain steps, such as surgery, to reduce their risk of developing cancer. Show More Summary

New research could significantly accelerate drug discovery

(University of Maryland School of Medicine) Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. Show More Summary

Patient-derived organoids may help personalize the treatment of gastrointestinal cancers

(Wiley) A new BJS (British Journal of Surgery) review highlights the potential of 3-D organoid models derived from patient cells to help personalize therapy for individuals with gastrointestinal cancers.

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