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Genetic Anomalies Linked to Breast Cancer in African American Families

The “Jewels in our Genes” study, led by University at Buffalo researcher Heather Ochs-Balcom, has uncovered previously unknown segments of DNA shared by African American family members who have breast cancer. “The discovery of these regions supports our hypothesis that there are still undiscovered breast cancer genes that may be unique to African Americans,” says […]

There’s No Reason to Exclude Cancer Survivors from Advanced Stage Lung Cancer Trials

A study by researchers from UT Southwestern Medical Center has found that the common practice of excluding patients with a prior cancer diagnosis from lung cancer clinical trials may not be medically justifiable. Having previously had cancer did not impact clinical outcomes in advanced lung cancer patients and these patients therefore should be considered for […]

New Lung Screening Guidelines Provide More Accurate Results

Lung screening is recommended for people age 55-80 who have smoked at least 30 pack years and are either current smokers or quit within the last 15 years. According to a new retrospective study, a set of guidelines developed to help standardized lung cancer screening would have generated considerably fewer false-positives than the National Lung Screening Trial […]

FDA Approves New Drug for Patients with Advanced Breast Cancer

The U.S. Food and Drug Administration today approved a potentially groundbreaking new drug to treat women with advanced breast cancer, signaling a new treatment strategy to arrest tumor growth and extend the time before the cancer worsens. The drug, IBRANCE (palbociclib) was studied in 165 post-menopausal breast cancer patients with advanced ER+, HER2- disease who […]

Rutgers Cancer Institute of New Jersey Investigators to Explore Melanoma Metastasis

The mechanism by which small cellular vesicles promote melanoma metastasis (spread of disease), will be further explored by investigators at Rutgers Cancer Institute of New Jersey and the Ernest Mario School of Pharmacy at Rutgers University. Show More Summary

New Cancer Cell Mapping Initiative Launches

In recent years, progress in genome sequencing has made it possible to decipher hundreds of mutations found in a patient’s tumor. But in only a few cases do scientists understand how these mutations give rise to cancer or indicate what treatments to pursue. More puzzling still, the mutations found in each patient are almost always […]

Is It Time For Precision/Personalized Medicine?

This blog was originally published on the Medpage Today website on January 22, 2015. It is reposted here with permission. ++++++++++++ Are we prepared for the genomics revolution? The President's proposed Precision Medicine Initiative...Show More Summary

Why Is Pancreatic Cancer So Aggressive?

Pancreatic cancer is often lethal, with fewer than a third of patients surviving even early stage disease. New research from the University of Michigan Comprehensive Cancer Center helps explain why this is the case. The researchers found a gene known to be involved in nearly 90 percent of pancreatic cancers promotes cancer growth and spread. The […]

In New Orleans’ Efforts To Make Bars and Casinos Smoke Free, It’s The Musicians’ Songs That Are the Sweetest.

Let's call it the Battle of New Orleans, 2015. As I write this, I am traveling from a meeting of the New Orleans City Council where testimony was heard regarding a new ordinance which would prohibit smoking in the city's famed bars and the local casino. Show More Summary

Many Women May Not Need Hysterectomy After All

It is estimated that one in three women in the United States will have had a hysterectomy by the age of 60. Although the numbers of hysterectomies are decreasing, a new study of more than three thousand women in Michigan who underwent hysterectomy for benign indications reveals that alternatives to hysterectomy are being underused and […]

Women with Atypical Hyperplasia Have a Higher Risk of Breast Cancer

A new Mayo Clinic study has found that women with atypical hyperplasia of the breast have a higher risk of developing breast cancer than previously thought. Results of the study appear in a special report on breast cancer in the New England Journal of Medicine. Atypical hyperplasia of the breast is a precancerous condition found […]

Cell’s “Biological Clock” May Hold Key to Promising Cancer Therapy

Cell biologists at UT Southwestern Medical Center have targeted telomeres with a small molecule called 6-thiodG that takes advantage of the cell’s ‘biological clock’ to kill cancer cells and shrink tumor growth. Dr. Jerry W. Shay, Professor and Vice Chairman of Cell Biology at UT Southwestern, and colleague, Dr. Woodring E. Wright, Professor of Cell Biology and Internal […]

New Therapy Doubles Survival Rates for Stage 4 Lung Cancer Patients

A clinical trial that combined stereotactic body radiation therapy with a specific chemotherapy regimen more than doubled survival rates for certain stage 4 lung cancer patients, UT Southwestern Medical Center cancer researchers report. Show More Summary

To Prevent Cancer After Radiation, Scientists Reprogram Stem Cells

The body has evolved ways to get rid of faulty stem cells. A University of Colorado Cancer Center study published today in the journal Stem Cells shows that one of these ways is a “program” that makes stem cells damaged by radiation differentiate into other cells that can no longer survive forever. Radiation makes a stem cell […]

Whole-Genome Sequencing Can Successfully Identify Cancer-Related Mutations

UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer, which can potentially lead to improvements in cancer prevention, diagnosis, and care. Show More Summary

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