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Terminally ill cancer patients fare poorly after surgery

(University of California - Davis Health System) Patients with disseminated advanced cancer who undergo surgery are far more likely to endure long hospital stays and readmissions, referrals to extended care facilities and death, UC Davis researchers have found.

A CSIC study aims to identify new bacterial regulators to improve human and animal health

(Spanish National Research Council (CSIC)) A project led by the Spanish National Research Council (CSIC) researcher, Alejandro Toledo-Arana, at the Institute of Agro biotechnology (a centre shared between CSIC, the Public UniversityShow More Summary

Genetic hallmarks of acute lymphoblastic leukemia subtype uncovered

Genetic changes underlying a type of B-precursor acute lymphoblastic leukemia have now been identified by a research team.

Active agent from the Caribbean sea cucumber could improve treatment for malignant pleural mesothelioma

Researchers have discovered a new option for treating malignant pleural mesothelioma. For the first time in the world, they were able to show in a preclinical study, both in the cell culture and in the animal model, that trabectedin,...Show More Summary

Big data methods under development at UGA will help tackle diseases

(University of Georgia) The University of Georgia's Ping Ma will use a new grant to crunch big data numbers, not uncommon for a statistics professor. What is unusual is that his work may help save lives.

New subtypes of lung cancer can lead to personalized therapies with better outcome

(Baylor College of Medicine) Analysis of vast amounts of molecular data from a set of more than 1,000 non-small cell lung cancers identifies distinct subtypes, each with its own molecular profile and potentially different response to therapy.

Fighting cancer with the power of immunity

(Massachusetts Institute of Technology) Researchers at MIT's Koch Institute for Integrative Cancer Research have developed a new strategy for using immunotherapy to treat cancer. The researchers used a combination of four different therapies...Show More Summary

Tumor markers can reveal lethality of bladder cancers, guide treatment

(University of Chicago Medical Center) Tumor cells collected during the removal of a cancerous bladder and transplanted into mice with weakened immune systems could help physicians rapidly identify high-risk cancers, determine prognosis and refine the use of biomarkers to personalize care for patients with this common cancer.

Study determines efficacy of 2 drugs to treat a form of leukemia

(Boston University Medical Center) Researchers have determined that two Phase 1 drugs (CX-4945 and JQ1) can work together to efficiently kill T-cell acute lymphoblastic leukemia cells while having minimal impact on normal blood cell...

A key to unlocking the mystery of triple negative breast cancer

(McGill University Health Centre) The study suggests screening breast cancer patients for the prolactin receptor could improve the prognosis for patient and may help them avoid unnecessary and invasive treatments. The researchers found that prolactin hormone was able to reduce the aggressive behavior of cancerous cells. Show More Summary

Study suggests that autophagy inhibitors could improve efficacy of chemotherapies

(JCI Journals) This week in the JCI, research led by Jayanta Debnath at UCSF has shown that inhibiting autophagy does not impair the immune response to tumors during chemotherapy, providing support for the idea that combining autophagy inhibitors with certain chemotherapies may aid cancer treatment.

What proportion of cancer deaths are attributable to smoking around the US?

(The JAMA Network Journals) The proportion of cancer deaths attributable to cigarette smoking varied across the United States but was highest in the South, where nearly 40 percent of cancer deaths in men were estimated to be connected to smoking in some states, according to a new article published online by JAMA Internal Medicine.

New guideline on calcium and vitamin D supplementation

(American College of Physicians) A new evidence-based clinical guideline from the National Osteoporosis Foundation and the American Society for Preventive Cardiology says that calcium with or without vitamin D intake from food or supplements that does not exceed the tolerable upper level of intake should be considered safe from a cardiovascular standpoint.

Polymer scaffolds build a better pill to swallow

Nanoparticle drugs can make it easier for medications to reach their targets, say researchers. The researchers have developed a polymeric 'scaffold' that helps drugs that often have trouble entering the bloodstream, such as anti-cancer agents, form highly stable nanoparticles with improved bioavailability.

Chemical inhibitor may provide lung cancer treatment

A chemical inhibitor that limits the growth of lung tumor cells has been identified by a team of researchers. The inhibitor works by partially disrupting glycosylation, the addition of sugar chains to proteins.

Insight on ovarian cancer

In a recent study, researchers have demonstrated that the tumors release substances called cytokines to attract macrophages.

Anti-cancer effects found in natural compound derived from onions

Research has found that a natural compound isolated from onions, onionin A (ONA), has several anti-ovarian cancer properties. This discovery is a result of research on the effects of ONA on a preclinical model of epithelial ovarian cancer (EOC) both in vivo and in vitro. This research comes from the same group that found ONA suppressed pro-tumor activation of host myeloid cells.

New compound shows promise in treating multiple human cancers

A newly discovered compound has been shown by researchers to block a protein that is essential for the sustained growth of up to a quarter of all cancers.

Study links changes in collagen to worse pancreatic cancer prognosis

The first evidence linking a disturbance of the most common protein in the body with a poor outcome in pancreatic cancer has been uncovered by a team of researchers.

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