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Chemical array draws out malignant cells to guide individualized cancer treatment

Melanoma is a particularly difficult cancer to treat once it has metastasized, spreading throughout the body. Researchers are using chemistry to find the deadly, elusive malignant cells within a melanoma tumor that hold the potential to spread. Show More Summary

Sweetening connection between cancer and sugar

Scientists have found that some types of cancers have more of a sweet tooth than others.

Preliminary: BRCA variations may work alongside COMT variation to reduce breast cancer

Researchers find through looking at genetic data sets of presumed cancer-free women who carry BRCA 1/2 variants, the co-occurrence of a rare COMT genetic variant in some women. This research outlines a strategy for looking at large genetic data sets for clues as to why a genetic carrier may never develop the associated diseases.

Many patients with early-stage breast cancer receive costly, inappropriate testing

A study shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.

A new way to slow cancer cell growth

Researchers have identified a new way to potentially slow the fast-growing cells that characterize all types of cancer. By removing a specific protein from cells, they were able to slow the cell cycle, which is out of control in cancer. Show More Summary

In fruit fly and human genetics, timing is everything

Using fruit flies, researchers have discovered a cascade of molecular signals that program gene activity to drive the fly from one stage of maturation to the next, like a baby turning into an adult. Part of this programming involves alterations to the way DNA is packaged. Show More Summary

Brain microenvironment makes HER2-positive breast cancer metastases resistant to treatment

A novel mechanism behind the resistance of breast cancer brain metastases to HER2- or PI3K-targeted therapies has been discovered, and a treatment strategy has now been identified that may overcome this resistance.

Metals from Bolivian mines affect crops and pose potential health risk, study suggests

Exposure to trace metals from potatoes grown in soil irrigated with waters from the Potosi mining region in Bolivia, home to the world's largest silver deposit, may put residents at risk of non-cancer health illnesses, researchers w...

Mathematical modeling can identify ways to limit aggressive tumor cell growth

Mathematical models can be used to predict how different tumor cell populations interact with each other and respond to a changing environment, research suggests.

Where body fat is carried can predict cancer risk

Carrying fat around your middle could be as good an indicator of cancer risk as body mass index (BMI), according to new research.

Breakthrough in better understanding acute myeloid leukemia

A study has made a breakthrough in the understanding of how different genetic mutations cause acute myeloid leukemia.

New guidance for targeting residual ovarian tumors

Researchers who are working on an implantable device that could make intraperitoneal chemotherapy more bearable have published a new study that offers insight into how to improve chemotherapy strategies for ovarian cancer, and how to determine which patients would be most likely to benefit from their device.

Tracking cancer's signaling pathways

Malignant melanoma is one of the most common and dangerous types of cancer. Researchers have investigated how and why brown pigmented moles turn into malignant melanoma using innovative robot technology. The insights gained can simplify methods of diagnosis in the future; furthermore, they suggest that certain cosmetic products and creams should be avoided.

Just one alcoholic drink a day increases breast cancer risk, exercise lowers risk

Drinking just one glass of wine or other alcoholic drink a day increases breast cancer risk, finds a major new report.

Flexible new method for early cancer diagnosis

Earlier discovery of cancer and greater precision in the treatment process are the objectives of a new method recently developed. Investments are now being made to roll out this innovation across healthcare and broaden the scope of the research in this field.

A new T-cell population for cancer immunotherapy

For the first time, scientists have described a new T cell population that can recognize and kill tumor cells. T lymphocytes (short T cells) are a special type of cells that recognize germs and protect our body from infections. Their second important job is to ride the body of harmed cells, such as tumor cells.

Injecting activator of a powerful tumor suppressor directly into the cancer increases tumor destruction, decreases toxicity

Directly injecting a tumor with an agent that activates a natural, powerful tumor suppressor enhances the drug's capacity to attack the tumor both locally and where it spreads, scientists report.

Study redefines HPV-related head and neck cancers

Much of what we thought we knew about the human papilloma virus (HPV) in HPV-related head and neck cancers may be wrong, according to researchers who analyzed data from The Human Cancer Genome Atlas. Head and neck cancers involving HPV are on the rise, and many experts believe we are seeing the start of an epidemic that will only get worse in the coming years.

An elegans solution: Worm genetic screen maps cell-to-cell communication in human cancer

Researchers have developed a cross-species genetic screen in worms to follow cell-to-cell communication in human cancer. The genome-wide screen is being used to chart a roadmap between mesodermal cells and epithelial cells in the tumor microenvironment.

RNA molecule that shields breast cancer stem cells from immune system

Researchers have identified a small RNA molecule that helps maintain the activity of stem cells in both healthy and cancerous breast tissue. The study suggests that this 'microRNA' promotes particularly deadly forms of breast cancer and that inhibiting the effects of this molecule could improve the efficacy of existing breast cancer therapies.

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