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How statins aid the immune system

Statins protect against cardiovascular disease in more ways than previously thought. In a new study, researchers are able to show the immunological effects of statins, and present a new hypothesis on why satins are effective at preventing heart attacks.

Skin cancer: Drug combination could improve immunotherapy

The results of studies show that the effect of immunotherapy on malignant melanoma (black skin cancer) can be improved by combining it with other cancer treatments. However, the results also show that this combination can lead to an increase in side-effects. Show More Summary

Blood pressure drug may boost effectiveness of lung cancer treatment

A blood pressure drug may make a type of lung cancer treatment more effective, suggests a new study. Almost 2 million people are diagnosed with lung cancer every year worldwide and it is the top international cancer killer. The team studied a lung cancer drug called erlotinib which can be used to treat between 10 and 30 per cent of lung cancer patients.

Regulatory RNA essential to DNA damage response

It iss essential for cells to quickly ascertain whether it's possible to repair mistakes or to self-destruct for the good of the organism. That's because cells with a damaged genome often begin to flout the standard rules of growth and become cancerous. Show More Summary

Iron nanoparticles make immune cells attack cancer

Iron nanoparticles can activate the immune system to attack cancer cells, according to a study. The nanoparticles, which are commercially available as the injectable iron supplement ferumoxytol, are approved by the Food and Drug Administration to treat iron deficiency anemia.

Tapping evolution to improve biotech products

Scientists can improve protein-based drugs by reaching into the evolutionary past, a new paper proposes. As a proof of concept for this approach, the research team showed how "ancestral sequence reconstruction" or ASR can guide engineering of the blood clotting protein known as factor VIII, which is deficient in the inherited disorder hemophilia A.

How cancer’s 'invisibility cloak' works

Researchers have discovered how cancer cells become invisible to the body's immune system, a crucial step that allows tumors to metastasize and spread throughout the body.

Medulloblastoma patients should receive both chemotherapy and radiation post-surgery

The addition of chemotherapy to postoperative treatment for adults with medulloblastoma improves survival, new research demonstrates. Medulloblastoma (MB) is the most common brain tumor in children, but is relatively rare in adults. Chemotherapy use in adult MB is largely based on pediatric outcomes, and its effectiveness has been unclear.

Custom-tailored strategy against glioblastomas

Glioblastomas are incurable malignant brain tumors. Usually the patients affected survive for only a few months. In addition, every tumor is quite different, which makes treatment very difficult. Researchers have now developed a completely new method as the basis for creating custom-tailored, two-stage therapies. Show More Summary

Melanoma tumors use interferon-gamma mutations to fight immunotherapy

Melanoma tumors use genetic mutations in a prominent immune response pathway to resist the immunotherapy ipilimumab, researchers report. These findings open the door to testing an array of IFN-y genes prospectively as a predictor for response to ipilimumab and for exploring new combinations to defeat IFN-y-related resistance.

New design of engineered arginine depleting enzymes as multi-potent anti-cancer agents

A novel multi-potent drug removes arginine from the blood and kills cancer cells, report scientists. Arginine is an essential amino acid for the growth of cancer cells.

Scientists spot genes that make some sarcomas less aggressive

A set of genes they say make sarcoma cells less aggressive has been discovered by researchers. They hope to turn the discovery into new therapeutic approaches to fight metastatic cancers.

Landmark Map Reveals the Genetic Wiring of Cellular Life

A new map breaks away from the old way of studying genes one at a time, showing how genes interact in groups to shed light on the genetic roots of diseases.

New hope in fight against aggressive, often hard to treat brain tumor

A potential way of stopping one of the most aggressive types of brain tumor from spreading has now been identified by researchers, which could lead the way to better patient survival. Glioblastoma is one of the most common types of malignant brain tumors in adults. Show More Summary

Immune and targeted therapies with radiation therapy improves outcomes for melanoma brain metastases patients, say researchers

Researchers have sought to determine if patients with melanoma brain metastases treated with immune and targeted therapies had improved outcomes over patients treated with conventional chemotherapy. They retrospectively analyzed data...Show More Summary

Tattoo therapy could ease chronic disease

A temporary tattoo to help control a chronic disease might someday be possible, according to scientists who tested newly created antioxidant nanoparticles.

Sweet news: Sucralose is not linked to cancer, study finds

In a society where obesity is increasingly recognized as a risk factor for disease, low- and no-calorie ingredients are logical choices for those wishing to manage their weight.  However, some people have concerns that sucralose, a no-calorie...Show More Summary

Sharpshooting nanoparticles hit the target

Multi stimuli-responsive nanocapsules selectively deliver drugs to exactly where they are needed, say researchers. The researchers created the multifunctional nanocapsules by wrapping magnetic iron oxide nanoparticles inside a biocompatible polymer coat that could be tuned to respond to acidity or temperature. Show More Summary

Swarms of magnetic bacteria could be used to deliver drugs to tumors

One of the biggest challenges in cancer therapy is being able to sufficiently deliver chemotherapy drugs to tumors without exposing healthy tissues to their toxic effects. Magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs, researchers have demonstrated.

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