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Melanoma tumors use interferon-gamma mutations to fight immunotherapy

Melanoma tumors use genetic mutations in a prominent immune response pathway to resist the immunotherapy ipilimumab, researchers report. These findings open the door to testing an array of IFN-y genes prospectively as a predictor for response to ipilimumab and for exploring new combinations to defeat IFN-y-related resistance.

New design of engineered arginine depleting enzymes as multi-potent anti-cancer agents

A novel multi-potent drug removes arginine from the blood and kills cancer cells, report scientists. Arginine is an essential amino acid for the growth of cancer cells.

Scientists spot genes that make some sarcomas less aggressive

A set of genes they say make sarcoma cells less aggressive has been discovered by researchers. They hope to turn the discovery into new therapeutic approaches to fight metastatic cancers.

Landmark Map Reveals the Genetic Wiring of Cellular Life

A new map breaks away from the old way of studying genes one at a time, showing how genes interact in groups to shed light on the genetic roots of diseases.

New hope in fight against aggressive, often hard to treat brain tumor

A potential way of stopping one of the most aggressive types of brain tumor from spreading has now been identified by researchers, which could lead the way to better patient survival. Glioblastoma is one of the most common types of malignant brain tumors in adults. Show More Summary

Immune and targeted therapies with radiation therapy improves outcomes for melanoma brain metastases patients, say researchers

Researchers have sought to determine if patients with melanoma brain metastases treated with immune and targeted therapies had improved outcomes over patients treated with conventional chemotherapy. They retrospectively analyzed data...Show More Summary

Tattoo therapy could ease chronic disease

A temporary tattoo to help control a chronic disease might someday be possible, according to scientists who tested newly created antioxidant nanoparticles.

Sweet news: Sucralose is not linked to cancer, study finds

In a society where obesity is increasingly recognized as a risk factor for disease, low- and no-calorie ingredients are logical choices for those wishing to manage their weight.  However, some people have concerns that sucralose, a no-calorie...Show More Summary

Sharpshooting nanoparticles hit the target

Multi stimuli-responsive nanocapsules selectively deliver drugs to exactly where they are needed, say researchers. The researchers created the multifunctional nanocapsules by wrapping magnetic iron oxide nanoparticles inside a biocompatible polymer coat that could be tuned to respond to acidity or temperature. Show More Summary

Swarms of magnetic bacteria could be used to deliver drugs to tumors

One of the biggest challenges in cancer therapy is being able to sufficiently deliver chemotherapy drugs to tumors without exposing healthy tissues to their toxic effects. Magnetic bacteria are a promising vehicle for more efficiently delivering tumor-fighting drugs, researchers have demonstrated.

Key requirement for regulatory T cell function discovered

A key requirement for the function of regulatory T cells—immune cells that play a critical role in many biological processes, from suppressing inflammation and deadly autoimmunity to helping tumors evade immune attack—is now better understood thanks to new research. Show More Summary

New insights into potent cancer tumor suppressor gene

TP53 is one of the most potent genes in the human genome at preventing cancer and hence is termed a tumor suppressor gene, explain researchers. The TP53 gene has even greater anti-cancer activity than previously thought, a new study suggests.

Unexpected cause of mutation in cancer identified

Researchers looking for a missing cause of a common type of mutation in breast cancer cells have uncovered the biochemical culprit and found that it may also be a general source of mutation in other cancer types.

New strategy identified for treating acute myeloid leukemia

A promising new approach to the treatment of acute myeloid leukemia (AML) has been discovered by a team of researchers. In their report, the investigators have identified a crucial dysfunction in blood cell development that underlies...Show More Summary

Neutrophils are key to harnessing anti-tumor immune response from radiation therapy, study finds

Combining targeted radiation therapy with a neutrophil stimulant enhances anti-tumor immunity, according to new research into cancer immunology.

Shedding light on the mutational landscape of the most common pediatric cancer

Genomic alterations have been discovered in pediatric relapsed ALL that cause both therapy resistance and improved clinical response to multi-agent chemotherapy treatment.

New immunotherapy for leukemia shows promise in small clinical trial

'Training' immune cells boosts effectiveness in patients with acute myeloid leukemia (AML), report scientists. A small clinical trial provides evidence that the immune system's "natural killer" cells can be dialed up in the laboratory, trained to recall that activation and then effectively unleashed to destroy cancer cells in some patients.

Gene therapy technique may help prevent cancer metastasis

A new gene therapy technique being developed is showing promise as a way to prevent breast cancer tumors from metastasizing. The treatment uses microRNAs -- small noncoding RNA molecules that regulate gene expression -- to control metastasis.

Decisions in a pinch: Receptor tyrosine kinases control mechanosensors

The role of receptor tyrosine kinases in the regulation of the cellular mechanosensory machinery is now better understood, This discovery has relevance for understanding the basis of cancerous growth and developmental abnormalities.

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