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New mechanisms of gene inactivation may prevent aging and cancer

Every cell in our body contains the complete DNA library. So-called methyl groups regulate that in body tissues only the genetic information is expressed that is indeed needed in this tissue. Now, for the first time, researchers verified that a lack of methyl groups in the gene body leads to an incorrect gene activation and, as a consequence, may lead to the emergence of cancer.

Novel 'barcode' tracking of T cells in immunotherapy patients identifies likely cancer-killers

A new discovery makes an important step in identifying which specific T cells within the diverse army of a person's immune system are best suited to fight cancer.

Do Fitness Trackers Help Us Lose Weight? The New York Times Says “No”; I Say “Not So Fast”

I am devoted to my fitness tracker, having used it for several years to remind me to be active, monitor my diet and improve my sleep. Now the New York Times tells me it doesn’t make a difference, at least when it comes to the weight loss part of the program. Show More Summary

Broad cancer vaccine may be out of reach

(BioMed Central) The high level of genetic diversity between individual tumors suggests that if it were to be developed, a broad cancer vaccine would be unlikely to work for more than 0.3 percent of the population, according to new research published in the open access journal Genome Medicine.

Death rates from cancer will fall faster in men than in women in Europe in 2017

Death rates from cancer in the European Union (EU) are falling faster in men than in women, according to the latest predictions for European cancer deaths in 2017. Compared with 2012, death rates in men will fall by just over eight percent to 132 per 100,000 of the population in 2017, while in women the decline will be around four percent to 84.5 per 100,000.

Gene mutations cause leukemia, but which ones?

New research sought to better understand one 'typo' in a standard leukemia assay, or test. The study, however, encountered a new problem: an issue with the model system itself.

Novel mutation may be linked to prostate cancer in African-American men

(PLOS) Researchers have identified a novel mutation that may be associated with prostate cancer in African-American men, according to a new study published in PLOS Computational Biology. Scientists have long known that a huge variety of DNA mutations can lead to cancer. Show More Summary

Tumor protein could hold key to pancreatic cancer survival

A diagnosis of pancreatic cancer is often a death sentence because current chemotherapies have little impact on the disease. In a new study, researchers were able to slow down growth and spread of tumors by targeting this protein in stellate cells in animal models, in combination with current chemotherapies.

Study reveals PGK1 enzyme as therapeutic target for deadliest brain cancer

(University of Texas M. D. Anderson Cancer Center) Discovery of a dual role played by the enzyme phosphoglycerate kinase 1 (PGK1) may indicate a new therapeutic target for glioblastoma, an often fatal form of brain cancer, according to researchers at The University of Texas MD Anderson Cancer Center.

Direct-to-consumer genomics: Harmful or empowering?

In a new study, a research explores questions that stem from new advances in direct-to-consumer DNA tests, which have the effect of separating the physician-patient relationship from access to new personal health data.

Compounds that show potent anti-cancer activity in breast and colon tumor cell lines

Potential drugs have shown low toxicity in non-tumor cell lines, which could decrease side effects during chemotherapy, researchers suggest.

PI3K/mTOR inhibitors may be effective against some uterine sarcomas

The protein P-S6S240 may serve as an indicator of poor prognosis for patients with a hard-to-treat type of uterine sarcoma called leiomyosarcoma, and preclinical data suggest that patients whose tumors have this protein may respond to PI3K/mTOR inhibitors.

Why is pancreatic cancer so hard to treat? Stroma provides new clues

(Cold Spring Harbor Laboratory) Why are pancreatic tumors so resistant to treatment? One reason is that the 'wound'-like tissue that surrounds the tumors, called stroma, is so dense, likely preventing cancer-killing drugs from reaching the tumor. A team has now discovered heterogeneity in the fibroblast portion of the stroma, opening up the possibility of targeted treatment.

Measuring patients' muscles to predict chemotherapy side effects

Measuring patients' muscle mass and quality could potentially help doctors better identify patients at high risk for toxic side effects that could require hospitalizations, researchers report.

Protein once thought exclusive to neurons helps some cancers grow, spread, defy death

How we think and fall in love are controlled by lightning-fast electrochemical signals across synapses, the dynamic spaces between nerve cells. Until now, nobody knew that cancer cells can repurpose tools of neuronal communication to fuel aggressive tumor growth and spread.

Incarceration linked to excess burden of cancer, new study finds

(St. Michael's Hospital) People who spend time in jails and prisons are more likely to develop certain types of cancer than the general population in Ontario, according to a study published today in the open-access journal PLOS ONE.They were also more than 50 per cent more likely to die from cancer than the general population in Ontario, the study found.

CAR T cells more powerful when built with CRISPR, researchers find

Researchers have harnessed the power of CRISPR/Cas9 to create more-potent chimeric antigen receptor (CAR) T cells that enhance tumor rejection in mice.

Nature study suggests new therapy for Gaucher disease

(Cincinnati Children's Hospital Medical Center) Scientists propose in Nature blocking a molecule that drives inflammation and organ damage in Gaucher, and maybe other lysosomal storage diseases, as a possible treatment with fewer risks and lower costs than current therapies. Show More Summary

Superfluid is now helping brain surgeons

A superfluid, which resembles brain tissue, makes ultrasound images easier to interpret during an operation. This will make it easier for surgeons to remove brain tumors more accurately, say researchers.

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