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New method to fight malaria found by scientists

Scientists have discovered a new way to slow down malaria infections, providing a possible new target for antimalarial drugs. The team are already working with pharmaceutical companies to use this knowledge to develop new antimalarials -- an important step in the battle against drug resistant malaria.

Terminal cancer patients can be unwilling to face prognosis

Just under 10% of patients diagnosed with terminal cancer did not know their prognosis and had no interest in finding out, suggests a new report.

How high-fat diet impacts colorectal cancer

A specific molecular pathway has been discovered that plays a key role in the link between a high-fat diet and tumor growth in the colon. The research team showed in pre-clinical models that cancer stem cell growth in the colon was enhanced by a high-fat, Western diet.

New brain cancer drug targets revealed

Researchers have developed a new method to screen brain tumor cells and identify potential drug targets missed by traditional methods. The team successfully used their technique to find a new drug target in glioblastoma that, when inhibited, significantly extended survival in preclinical mouse models.

Visualizing whole-body cancer metastasis at the single-cell level

A new method to visualize cancer metastasis in whole organs at the single-cell level has now been developed by researchers. A new study describes a new method that combines the generation of transparent mice with statistical analysis to create 3-D maps of cancer cells throughout the body and organs.

Watching cancer spread in a mouse

A new method has been developed to image cancer at the single-cell level by using chemical techniques to make whole mouse bodies and organs highly transparent. Combining their preparation with existing imaging technology, they were able...Show More Summary

Freeze-frames of enzymes in action have implications for a new cancer treatment concept

Structural biologists shed light on how a family of enzymes called TUTases regulate let-7, an essential regulator of development that is dyregulated in lung and kidney cancers, among others. The team used x-ray crystallography to capture...Show More Summary

3D-printed robot aims to fight cancer

The world’s smallest and most accurate 3D-printed biopsy robot has been revealed by developers.

Female cancer survivors are one-third less likely to achieve pregnancy than women in general population

For the first time, a large population study has quantified the chance of pregnancy after treatment for cancer diagnosed in girls and women aged 39 or under. This landmark study, which linked all cancers diagnosed in Scotland between...Show More Summary

New way to tackle cancer cells

Scientists have introduced, for the first time, the organelle-localized self-assembly of a peptide amphiphile as a powerful strategy for controlling cellular fate.

Liquid biopsies: A non-invasive look at treatment response

A new study shows that so-called "liquid biopsies", blood tests that detect circulating tumour DNA (ctDNA), may not only sound an early alert that a treatment's effect is diminishing, but may also help explain why -sometimes offering clues about what to do next.

How telomeres protect cells from premature senescence

Researchers have further uncovered the secrets of telomeres, the caps that protect the ends of our chromosomes. They discovered that an RNA molecule called TERRA helps to ensure that very short (or broken) telomeres get fixed again. The work provides new insights into cellular processes that regulate cell senescence and survival in aging and cancer.

Subtle molecular changes along the upper digestive tract could guide cancer therapy

Based on a new molecular study of tissues biopsied from various parts of the upper digestive tract, researchers have identified significant, if subtle, differences in gene mutations and other factors that could help in developing more tailored treatment options for cancer patients.

New mechanism found for keeping DNA protein in line

Electrostatic forces known as phosphate steering help guide the actions of an enzyme called FEN1 that is critical in DNA replication and repair, finds a new study. The findings help explain how FEN1 distinguishes which strands of DNA to target, revealing key details about a vital process in healthy cells as well as providing new directions for cancer treatment research.

Cancer researchers overestimate reproducibility of preclinical studies

Cancer scientists overestimate the extent to which high-profile preclinical studies can be successfully replicated, new research suggests.

Why the immune system fails to see cancer

A critical strategy that some cancers may be using to cloak themselves has been uncovered by investigators. The researchers have found evidence of this genetic program across 30 human cancers of the peripheral tissue, including melanoma skin cancer.

Test identifies breast cancer patients with lowest risk of death

A molecular test can pinpoint which patients will have a very low risk of death from breast cancer even 20 years after diagnosis and tumor removal, according to a new clinical study. As a result, 'ultralow' risk patients could be treated less aggressively and overtreatment avoided, leading to fewer toxic effects.

Manipulating 'signaling' molecules to control cell migration

A mechanism in amoebae that rapidly changes the way cells migrate by resetting their sensitivity to the naturally occurring internal signaling events that drive such movement has now been discovered by researchers, outlines a new report.

Promising new therapeutic approach for debilitating bone disease

A new type of therapeutic could greatly reduce bone disease in patients with the bone cancer, multiple myeloma. Multiple myeloma is a cancer that develops in bone, causing progressive bone destruction, bone fractures, and often devastating pain. Show More Summary

Treatment benefits patients with thalassaemia and HCV

Many individuals with the blood disorder thalassaemia also carry the hepatitis C virus (HCV) due to contaminated transfusions before 1990. Due to the co-existence of iron overload (from repeated blood transfusions), these patients are at increased risk of developing liver cancer. Show More Summary

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