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Deficiencies in repair of DNA identified in many types of solid tumors

(Georgetown University Medical Center) A new investigation of more than 48,000 stored tumor samples finds evidence of a key deficiency in a repair mechanism designed to keep DNA from being mutated and causing cancer.

Tumor cells get stiff before becoming invasive

(Instituto Gulbenkian de Ciencia) A study published now on Nature Communications shows that breast cancer cells undergo a stiffening state prior to acquiring malignant features and becoming invasive. The discovery made by a researchShow More Summary

Breast cancer risk is more affected by total body fat than abdominal fat

(Society for Endocrinology) A reduction in overall body fat, rather than abdominal fat, is associated with lower levels of breast cancer markers. The study published in Endocrine-Related Cancer, found that levels of several breast cancer risk markers were reduced in postmenopausal women who lost total body fat, rather than just belly fat. Show More Summary

Some mother cells kick DNA damage 'down the road' to offspring, CU study says

(University of Colorado at Boulder) A new University of Colorado Boulder study has shown that some dividing human cells are 'kicking the can down the road,' passing on low-level DNA damage to offspring, causing daughter cells to pause in a quiescent, or dormant, state previously thought to be random in origin.

Pitt analysis determines odds of a hookah non-smoker taking first puff

(University of Pittsburgh Schools of the Health Sciences) A positive attitude toward and desire to take up hookah smoking are the most likely predictors of a young adult becoming a hookah tobacco smoker, University of Pittsburgh researchers found in the first nationally representative analysis of hookah use by young adults over an extended follow-up period.

Clinics should choose women's breast screening appointment times to improve attendance

(Queen Mary University of London) For women who miss a breast screening appointment, giving a fixed date and time for a new appointment could improve poor attendance and be a cost-effective way to shift national participation trends, according to an analysis led by Queen Mary University of London (QMUL).

Metabolic peculiarities betray the identity of relapse-causing breast cancer cells

(JCI Journals) Relapsing breast cancer is a leading cause of cancer-related death in women, and relapse-causing tumor cells are difficult to identify and target during remission. In a study published this week in the JCI, research led...Show More Summary

Cell changes drive breast cancer relapse

(European Molecular Biology Laboratory) Relapse is now the main cause of death for breast cancer patients. Researchers at EMBL have found that, in mice, the tumor cells that survive therapy and eventually cause a relapse have specific traits that distinguish them from healthy cells. Show More Summary

Tumor-trained T cells go on patrol

(Garvan Institute of Medical Research) In cancer, immune cells infiltrate tumors -- but it hasn't been known which immune cells exit the tumor or where they go next.Garvan researchers have shown that activated T cells are the main immune...Show More Summary

WSU researchers deliver first 'nanotherapeutics' to tumor

(Washington State University) For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

New finding affecting immune reconstitution related to B cells

(Children's Hospital Los Angeles) Researchers from the Children's Center for Cancer and Blood Diseases at Children's Hospital Los Angeles examined the mechanisms of B cell immune reconstitution in pediatric patients who had undergone...Show More Summary

Study: New blood test is more accurate in predicting prostate cancer risk than PSA

(Cleveland Clinic) A team of researchers led by Cleveland Clinic have demonstrated that a new blood test known as IsoPSA detects prostate cancer more precisely than current tests in two crucial measures -- distinguishing cancer fromShow More Summary

Strategy significantly boosts colorectal screening for groups with low rates

(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger Comprehensive Cancer Center researchers and collaborators report in the Journal of the American Medical Association Internal Medicine that providing one-on-one support and customized tools for decision-making increased screening rates for patients at two community health centers in North Carolina and New Mexico.

Simple post-surgery step significantly reduces bladder cancer recurrence

(SWOG) It's just one step. Flushing the bladder with a common chemotherapy drug after a cancerous tumor is surgically removed reduces the chances of that cancer returning. Canadian and European clinical trials have proven this true and now a major US study has done the same. Show More Summary

Cutting smoking rates could save the NHS £67 million a year

(Cancer Research UK) If smoking rates dropped to 5 percent in the UK by 2035, the NHS could save £67million in just one year, according to research published in Tobacco Control today.

First study of Oncolytic HSV-1 in children & young adults with cancer indicates safety, tolerability

(Nationwide Children's Hospital) HSV1716 -- an oncolytic herpes simplex virus-1 -- has been studied in adults via injection into the brain and superficial tumors. Now, a team of researchers at Nationwide Children's Hospital and Cincinnati...Show More Summary

Molecular imaging reveals mechanism for resistance to immune checkpoint blockade

(Massachusetts General Hospital) A study from Massachusetts General Hospital investigators has identified a surprising mechanism for resistance to immune checkpoint blockade. The study finds in a mouse model that an antibody-based drug designed to block the immunosuppressive molecule PD-1 is removed from its target T cells by macrophages.

Tumor-dwelling immune cells thwart cancer immunotherapy

(American Association for the Advancement of Science) Researchers have caught tumor-associated immune cells called macrophages in the act of stealing checkpoint inhibitor antibodies away from their intended T cell targets, and blocking this thievery led to improved therapeutic responses in tumor-bearing mice.

Team uncovers novel epigenetic changes in leukemia

(University of Texas Health Science Center at San Antonio) UT Health San Antonio researchers discovered epigenetic changes that contribute to one-fifth of cases of acute myeloid leukemia (AML), an aggressive cancer that arises out of the blood-forming cells in bone marrow. Show More Summary

Biologists identify key step in lung cancer evolution

(Massachusetts Institute of Technology) MIT biologists have identified a major switch that occurs as lung adenomas transition to more aggressive adenocarcinomas -- and that blocking this switch prevents the transition. The findings suggest drugs interfering with this switch could be useful in treating early-stage lung cancers.

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