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Biochemists simulate a protein-folding chaperone's functional dance

Using a combination of computational and experimental techniques, a research team has demystified the pathway of interdomain communication in a family of proteins known as Hsp70s -- a top target of dozens of research laboratories trying to develop new anti-cancer drugs, antibiotics and treatments for Alzheimer's and Parkinson's diseases.

HPV vaccination rates especially low among childhood cancer survivors

(American Society of Clinical Oncology) The rate of human papilloma virus (HPV) vaccination in the United States is increasing, but remains lower than ideal. A new study suggests that survivors of childhood cancer receive the HPV vaccine at an even lower rate than their peers without cancer -- 24 percent versus 40 percent. Show More Summary

Pathway's power to boost, halt tumors may be promising cancer therapy target

(Penn State) A protein, called inositol-requiring enzyme 1 -- IRE1 -- may serve as a key driver in a series of molecular interactions that can both promote and, paradoxically, inhibit tumors in certain types of cancers, such as non-melanoma skin cancers, according to a team of molecular biologists. Show More Summary

Boosting immune cell memory to improve vaccines and cancer immunotherapy

Drugs that activate the cells' proteasome, or recycling center, tip the balance in favor of memory CD8+ T cells, studies on mice show. This approach could be used to improve how well vaccines and immunotherapies work and how long they last.

Complete remission of brain metastasis of difficult-to-treat tumor

Medical researchers report a remarkable treatment response in a patient participating in a clinical trial of a novel immune-system-based cancer therapy.

New app uses smartphone selfies to screen for pancreatic cancer

A new app could lead to earlier detection of pancreatic cancer simply by snapping a smartphone selfie. The disease kills 90 percent of patients within five years, in part because there are no telltale symptoms or non-invasive screening tools to catch a tumor before it spreads.

Mass. General team reports first response of central nervous system tumor to CAR T-cells

(Massachusetts General Hospital) In a letter to the New England Journal of Medicine, a Massachusetts General Hospital research team reports a remarkable treatment response in a patient participating in a clinical trial of a novel immune-system-based cancer therapy.

Combination of conventional and new drugs enhances tumor cell death

A group of researchers tested the therapeutic effect of a combination of conventional -- common anti-cancer agents -- and new drugs -- under clinical trials.

Concurrent treatment with OX40- and PD1-targeted cancer immunotherapies may be detrimental

Concurrent administration of the T-cell stimulating anti-OX40 antibody and the immune checkpoint inhibitor anti-PD1 antibody attenuated the effect of anti-OX40 and resulted in poor treatment outcomes in mice.

Statins linked to lower rates of breast cancer and mortality

A 14 year study in more than one million people has found that women with high cholesterol have significantly lower rates of breast cancer and improved mortality. The research suggests that statins are associated with lower rates of breast cancer and subsequent mortality.

Study paves the way for cancer treatments that might prevent relapses after radiotherapy

(Fundação de Amparo à Pesquisa do Estado de São Paulo) Brazilian researchers suggest that the combination of drugs that block a protein called PAF-R may increase radiotherapy's killing of tumor cells by one third. The experiments that...Show More Summary

10 million reasons that treatment of cancers caused by viruses may advance

(Louisiana State University Health Sciences Center) The National Institute of General Medical Sciences has awarded LSU Health New Orleans a $10 million grant over five years to support new basic research studies advancing the development new diagnostic and therapeutic approaches for virus-induced cancers.

HPV vaccination rates lag for vulnerable population of childhood cancer survivors

(St. Jude Children's Research Hospital) Research suggests health providers are key to boosting HPV vaccination rates of childhood cancer survivors, who, as a group, are at increased risk for second cancers associated with the human papillomavirus.

New app assesses radiation dosage in pediatric imaging

(SPIE--International Society for Optics and Photonics) An application giving neurosurgeons the ability to manipulate 3-D models of pediatric patients' neuroanatomy for tailoring radiation doses for accurate imaging has been developed by researchers from Duke University Medical Center and the Cleveland Clinic. Show More Summary

Scientists characterize regulatory DNA sequences responsible for human diseases

Scientists have developed an innovative system to identify and characterize the molecular components that control the activities of regulatory DNA sequences in the human genome.

DNA sensor plays critical role in cancer immunotherapy via response to unexpected DNA form

(UT Southwestern Medical Center) UT Southwestern Medical Center researchers report for the first time that tumors stressed by cancer immunotherapy release their mitochondrial DNA into nearby immune cells, triggering a host alert sys...

New ambitious research program receives big grant for research into leukemia

(University of Copenhagen The Faculty of Health and Medical Sciences) The newly established research program, 'Programme for Translational Hematology,' has just received DKK 100 million in funding from the Novo Nordisk Foundation.

Researcher identifies a new way to treat HIV

Medical treatment that targets human proteins rather than ever-mutating viruses may one day help HIV-positive people whose bodies have built a resistance to 'cocktails' currently used to keep them healthy. Now researchers have pinpointed a protein variant that can be targeted to prevent the human immunodeficiency virus from harming HIV-positive individuals.

Giving cancer-killing viruses a boost

(American Association for the Advancement of Science) Scientists have found a compound that helped a tumor-targeting virus kill liver cancer more effectively while sparing healthy cells, which could someday translate to a viable treatment approach in humans.

Putting it to the test

A rapid portable screening test for liver cancer has been created that doesn't involve sending a specimen to a blood lab and cuts the wait time for results from two weeks to two minutes. This inexpensive test can be administered wherever the patient is, which will be valuable for developing nations with little access to hospitals.

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