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New Cancer Cell Mapping Initiative Launches

In recent years, progress in genome sequencing has made it possible to decipher hundreds of mutations found in a patient’s tumor. But in only a few cases do scientists understand how these mutations give rise to cancer or indicate what treatments to pursue. More puzzling still, the mutations found in each patient are almost always […]

Is It Time For Precision/Personalized Medicine?

This blog was originally published on the Medpage Today website on January 22, 2015. It is reposted here with permission. ++++++++++++ Are we prepared for the genomics revolution? The President's proposed Precision Medicine Initiative...Show More Summary

Why Is Pancreatic Cancer So Aggressive?

Pancreatic cancer is often lethal, with fewer than a third of patients surviving even early stage disease. New research from the University of Michigan Comprehensive Cancer Center helps explain why this is the case. The researchers found a gene known to be involved in nearly 90 percent of pancreatic cancers promotes cancer growth and spread. The […]

In New Orleans’ Efforts To Make Bars and Casinos Smoke Free, It’s The Musicians’ Songs That Are the Sweetest.

Let's call it the Battle of New Orleans, 2015. As I write this, I am traveling from a meeting of the New Orleans City Council where testimony was heard regarding a new ordinance which would prohibit smoking in the city's famed bars and the local casino. Show More Summary

Many Women May Not Need Hysterectomy After All

It is estimated that one in three women in the United States will have had a hysterectomy by the age of 60. Although the numbers of hysterectomies are decreasing, a new study of more than three thousand women in Michigan who underwent hysterectomy for benign indications reveals that alternatives to hysterectomy are being underused and […]

Women with Atypical Hyperplasia Have a Higher Risk of Breast Cancer

A new Mayo Clinic study has found that women with atypical hyperplasia of the breast have a higher risk of developing breast cancer than previously thought. Results of the study appear in a special report on breast cancer in the New England Journal of Medicine. Atypical hyperplasia of the breast is a precancerous condition found […]

Cell’s “Biological Clock” May Hold Key to Promising Cancer Therapy

Cell biologists at UT Southwestern Medical Center have targeted telomeres with a small molecule called 6-thiodG that takes advantage of the cell’s ‘biological clock’ to kill cancer cells and shrink tumor growth. Dr. Jerry W. Shay, Professor and Vice Chairman of Cell Biology at UT Southwestern, and colleague, Dr. Woodring E. Wright, Professor of Cell Biology and Internal […]

New Therapy Doubles Survival Rates for Stage 4 Lung Cancer Patients

A clinical trial that combined stereotactic body radiation therapy with a specific chemotherapy regimen more than doubled survival rates for certain stage 4 lung cancer patients, UT Southwestern Medical Center cancer researchers report. Show More Summary

To Prevent Cancer After Radiation, Scientists Reprogram Stem Cells

The body has evolved ways to get rid of faulty stem cells. A University of Colorado Cancer Center study published today in the journal Stem Cells shows that one of these ways is a “program” that makes stem cells damaged by radiation differentiate into other cells that can no longer survive forever. Radiation makes a stem cell […]

Whole-Genome Sequencing Can Successfully Identify Cancer-Related Mutations

UT Southwestern Medical Center cancer researchers have demonstrated that whole-genome sequencing can be used to identify patients’ risk for hereditary cancer, which can potentially lead to improvements in cancer prevention, diagnosis, and care. Show More Summary

Understanding How Lung Cancer Spreads

UK scientists have taken microscopic images revealing that the protein ties tethering cells together are severed in lung cancer cells – meaning they can break loose and spread, according to research recently published in Cell Reports. The researchers at the Cancer Research UK Manchester Institute discovered that the ties which lash cells together – controlled […]

How Red Wine Prevents Cancer

Alcohol use is a major risk factor for head and neck cancer. But an article published in the November issue of the journal Advances in Experimental Medicine and Biology shows that the chemical resveratrol found in grape skins and in red wine may prevent cancer as well. “Alcohol bombards your genes. Your body has ways to repair […]

Synthetic Molecule JK-31 Helps Fight Cancer

A study recently published in the journal PLOS ONE reports that the synthetic molecule JK-31 blocks the signalling of a “growth factor” chemical that promotes the creation of networks of blood vessels to feed tumours. Researchers at the University of Leeds have made a new synthetic anti-cancer molecule that targets two key mechanisms in the spread […]

New Form of Testing May Speed up Childhood Cancer Diagnosis

Each year almost 1,600 children are diagnosed with cancer in the UK. These cancers tend to behave differently to cancers in adults and therefore require different treatments. The researchers, from the University of Cambridge and Addenbrooke’s Hospital in Cambridge, found unique molecular fingerprints for 11 types of children’s tumors, which could be used to develop […]

Number Of Skin Cancers And Costs Of Treatment Have Increased Dramatically Reinforcing Need For Prevention

The numbers about skin cancer incidence and costs in the United States are worse than anyone expected. That's the message that comes from a report published recently in the American Journal of Preventive Medicine on research from the...Show More Summary

Defining Value in Cancer Care Depends On Your Perspective

(This blog was originally posted on Medpage Today and is reprinted here with permission) +++++++++++ Value. A simple word with lots of meanings, all of which depend on the context of the moment. Value in healthcare -- especially in cancer care -- is certainly no exception. Show More Summary

Prostate Cancer Patients Surveyed

A comparison of five-year sexual function outcomes, as reported by patients treated with external beam radiotherapy (EBRT) versus combination EBRT plus brachytherapy, indicates that the utilization of vessel-sparing radiation therapy makes cure possible without compromising long-term sexual function. Show More Summary

CanceRX 2014: We Need Innovative Approaches To Support Cancer Drug Development

What if you were sitting in the room with some of the best financial and scientific minds in the country and someone asked how many of you would be willing to contribute a modest sum of money to create a company with the potential of...Show More Summary

Kidney Cancer Study Confirms Aristolochic Acid Is a Carcinogen

Kidney cancer kills more than 140,000 people every year. In Central Europe, incidence rates have been increasing dramatically. New research by the international Cancer Genomics of the Kidney consortium reveals an important connection between kidney cancer and exposure to aristolochic acid, an ingredient in some herbal remedies. Show More Summary

Prostate Cancer Recurrence Risk Much Greater Due to Elevated Cholesterol and Triglyceride Levels

Higher levels of total cholesterol and triglycerides, two types of fat, in the blood of men who underwent surgery for prostate cancer, are associated with increased risk for disease recurrence, according to a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. “While laboratory studies support an […]

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