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HPV vaccine also prevents uncommon childhood respiratory disease, study suggests

(Infectious Diseases Society of America) The vaccine that protects against cancer-causing types of human papillomavirus (HPV) also prevents an uncommon but incurable childhood respiratory disease, according to a new study published in The Journal of Infectious Diseases.

Cancer drug parity laws lower costs for many, but not everyone

(UNC Lineberger Comprehensive Cancer Center) State laws designed to ensure that the pill form of cancer drugs is not costlier than treatments given through an infusion in a clinic or hospital have had a mixed impact on patients' pocketbooks, according to University of North Carolina Lineberger Comprehensive Cancer Center researchers. Show More Summary

Th1/17 hybrid T cells offer potent and durable anti-tumor response in preclinical model

(Medical University of South Carolina) Adoptive cell therapy for cancer involves harvesting T cells from a patient and expanding and sometimes modifying them in the laboratory before reinfusion. It has been challenging to create T cells that are both potent and durable. Show More Summary

Cell signaling interaction may prevent key step in lung cancer progression, study shows

A novel cell signaling interaction that may prevent a key step in lung cancer progression, new findings reveals.

Scientists create a recipe to make human blood-brain-barrier

A defined, step-by-step process to make a more exact mimic of the human blood-brain-barrier in the laboratory dish has now been detailed by researchers in a new report. The new model will permit more robust exploration of the cells, their properties and how scientists might circumvent the barrier for therapeutic purposes.

UK study shows cell signaling interaction may prevent key step in lung cancer progression

(University of Kentucky) New findings from University of Kentucky faculty published in Scientific Reports reveals a novel cell signaling interaction that may prevent a key step in lung cancer progression.

Misregulated protein breakdown promotes leukemias and brain cancer

An enzyme that is responsible for the breakdown of specific amino acids in food plays a key role in the development of leukemias and brain cancer, scientists have now reported. The researchers have hence discovered a surprising link between energy metabolism and the so-called epigenetic code. Show More Summary

How cells detect, mend DNA damage may improve chemotherapy

Human cells have a way of detecting and mending DNA damage caused by some common chemotherapy drugs, according to a new study. The findings could have important implications for treating cancer.

Fighting cancer with cancer: 3-D cultured cells could drive precision therapy

(University of Michigan) Honeycomb-like arrays of tiny, lab-grown cancers could one day help doctors zero in on individualized treatments for ovarian cancer, an unpredictable disease that kills more than 14,000 women each year in the United States alone.

Chronic stress hormones may promote resistance to EGFR inhibitors in lung cancer patients

(University of Texas M. D. Anderson Cancer Center) Elevated levels of chronic stress hormones, such as those produced by psychological distress, may promote resistance to drugs commonly used to treat lung cancer patients with EGFR mutations, according to new research from The University of Texas MD Anderson Cancer Center. Show More Summary

Misregulated protein breakdown promotes leukemias and brain cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) An enzyme that is responsible for the breakdown of specific amino acids in food plays a key role in the development of leukemias and brain cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now reported in Nature. Show More Summary

How cells detect, mend DNA damage may improve chemotherapy

(Washington University School of Medicine) Human cells have a way of detecting and mending DNA damage caused by some common chemotherapy drugs, according to a new study from Washington University School of Medicine in St. Louis. The findings could have important implications for treating cancer.

How chronic inflammation tips the balance of immune cells to promote liver cancer

(University of California - San Diego) Chronic inflammation is known to drive many cancers, especially liver cancer. Researchers have long thought that's because inflammation directly affects cancer cells, stimulating their division and protecting them from death. Show More Summary

Breast cancer recurrence risk lingers years after treatment ends

(Michigan Medicine - University of Michigan) Even 20 years after a diagnosis, women with a type of breast cancer fueled by estrogen still face a substantial risk of cancer returning or spreading, according to a new analysis from an international team of investigators published in the New England Journal of Medicine.

First mathematical model that predicts immunotherapy success

Researchers have created the first mathematical model that can predict how a cancer patient will benefit from certain immunotherapies, according to a study.

Bringing natural killer cells to the tumor battlefield

By studying melanoma, a highly malignant form of skin cancer, medical researchers have revealed a mechanism by which the immunosuppressive environment can be switched to an immunosupportive one. They found that if autophagy -- the intracellular recycling process -- is blocked in tumor cells, they produce cytokines that attract NK cells. Show More Summary

Tumor analysis post-surgery provides breakthrough in how patients respond to treatment

Researchers have developed a new platform for assessing anti-cancer drug efficacy in lung cancer that is more reflective of patient response than previously used model systems. The platform relies on the derivation of 'explants' from tumor tissue obtained fresh from surgery and treatment of these samples ex vivo with anti-cancer drugs. Show More Summary

IUDs may have a surprising benefit: Protection against cervical cancer

IUD use is associated with a dramatic decrease in the incidence of cervical cancer, a new study has found.

Immune cell policing offers insights into cancer, autoimmune disease

Cutting off energy production in regulatory T cells impairs their function, new research has discovered.

Fat cells may inactivate chemotherapeutic drug

(American Association for Cancer Research) Adipocytes, or fat cells, can absorb and metabolize the chemotherapeutic agent daunorubicin, reducing the effectiveness of the drug and potentially contributing to poorer treatment outcomes...

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