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Multiple sclerosis: Newly discovered signal mechanism causes T cells to turn pathogenic

Multiple sclerosis is an autoimmune disease in which the body's immune system attacks the patient's own cells. In this case, modified T cells destroy the myelin sheath surrounding nerve cells. Myelin protects the neural pathways and is thus essential to the ability of nerve cells to transmit information. Show More Summary

Where MS and Depression Overlap

Multiple sclerosis can, as we all know too well, affect every part of the body that is controlled by the central nervous system. That means it can affect every part of the body. The way in which MS attacks the brain, coupled with our system’s way of fighting back, can also lead to clinical depression. […]

10 Ways to Avoid Becoming Invisible With an Invisible Disease

My name is Trevis L. Gleason, and I live with multiple sclerosis (MS). MS is a neurodegenerative disease of the central nervous system that can affect all aspects of life — the visible and the invisible. I must admit to you that this post was begun as a lament about the very real prospect of […]

Finding Your New Normal

It's 9 am on a Friday morning as I sit patiently awaiting an IV so I can begin my infusion. I make small talk with the nurses after taking my routine pregnancy test to ensure my heavy-duty medicine doesn't harm my apparent unborn child. Show More Summary

The Moment

Life altering events come in various forms. It could be one brief moment, a snapshot in time; or perhaps extend over a week, months or even a year. Sometimes it’s pretty obvious to recognize; in other instances, it might not fully register or become clear until later...

Bedside Thoughts

I write this from my wife’s bedside in an acute respiratory rehabilitation unit in a South Florida hospital. We are beginning our 7 th week of hospitalization. You may ask yourself, “What does the journey of this couple have to do with...Show More Summary

It’s Time to Check in With Yourself

Every month, we try to do a little check-in with one another (and ourselves) to see how our MS symptoms are acting that day. We’ve been doing this for a long time — nearly as long as the Life with Multiple Sclerosis blog has been running. It’s a place to gauge our disease and how […]

Mapping the biology of drug-resistant multiple sclerosis

People suffering from multiple sclerosis have relied on a drug called interferon-beta to prevent flare-ups of the disease and avoid its crippling neurological symptoms. But interferon-beta treatment has its downsides: the drug is expensive, it can cause flu-like side-effects, and for up to half of patients, it simply doesn't work. Show More Summary

There’s Value in Being an Expert Patient

It’s not often that I think of myself as an MS “patient.” Like many of you, I try to think of myself as a person living with multiple sclerosis. I’m not afflicted by it, I’m not an “MSer” (though I do understand why many identify with this moniker), and please don’t ever call me an […]

A Kidney Stone Plus Old MS Symptoms Try My Patience

I don’t remember exactly where I heard or read a phrase about being the beneficiary of other people’s patience. I do seem to remember that it was in a negative context and that it had to do with the decline of existence. Something like, “with nothing left but to be the beneficiary of other people’s patience…” I’m beginning […]

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