Neuroscientists who study memory have long believed that when we recall an event, our brains turn on the same hippocampal circuit that was activated when the memory was originally formed. However, neuroscientists have now shown, for the first time, that recalling a memory requires a 'detour' circuit that branches off from the original memory circuit.
Alzheimer's disease (AD) represents the leading cause of dementia worldwide. Currently, challenges in making an early and definitive diagnosis of AD limit opportunities to intervene with disease-modifying therapies before substantial neurodegeneration occurs. Show More Summary
Navigation in mammals including humans and rodents depends on specialized neural networks that encode the animal’s location and trajectory in the environment, serving essentially as a GPS, findings that led to the 2014 Nobel Prize in Medicine. Show More Summary
To determine why more aerobically fit individuals have better memories, scientists used magnetic resonance elastography (MRE), which measures the elasticity of organs, and found that fit individuals had a firmer, more elastic hippocampus—a region of the brain associated with memory.
Guilt may be the most annoying of the "seven deadly emotions" of Alzheimer's caregiving. It's right up there with resentment, worry, fear, anger, loneliness, and grief. By Paula Spencer ScottAlzheimer's Reading RoomGuilt is especially bothersome because it tends to be the least rooted in reality. Show More Summary
Researchers can reverse memory loss in mice by interfering with the enzyme that forms the blockade. The enzyme, known as HDAC2, turns genes off by condensing them so tightly that they can't be expressed.
Human-computer interactions, such as playing video games, can have a negative impact on the brain, says a new Canadian study. For over 10 years, scientists have told us that action video game players exhibit better visual attention, motor control abilities and short-term memory. But, could these benefits come at a cost?
Researchers have devised a new way to monitor sleep without any kind of sensors attached to the body. Their sensor uses low-power radio waves that detect small changes in body movement caused by the patient's breathing and pulse, then translates those measurements into sleep stages: light, deep, or rapid eye movement (REM).
In the largest functional brain imaging study to date, researchers compared 46,034 brain SPECT (single photon emission computed tomography) imaging studies provided by nine clinics, quantifying differences between the brains of men and women.
Researchers have discovered that defects in the transport of lysosomes within neurons promote the buildup of protein aggregates in the brains of mice with Alzheimer's disease. The study suggests that developing ways to restore lysosome transport could represent a new therapeutic approach to treating the neurodegenerative disorder.
I wondered if instead of complaining, could I replace the "bad" patterns of behavior that come along with dementia, patterns that were driving me crazy, with "new" more positive patterns of behavior? Always Be Kinder Than You Feel By...Show More Summary
Even when Alzheimer's is at an advanced stage you can get through to the patient using these simple communication techniques. By Carole B. Larkin Alzheimer's Reading RoomI had an ah ha moment reading this Parade Magazine article (which I edited for length). Show More Summary
A new study provides extensive evidence of Alzheimer’s disease pathology in the brains of aged chimpanzees, our closest living relatives. By Alzheimer's Reading Room This research adds to a growing number of studies using an evolutionary...Show More Summary
The search for new drugs and treatments for Alzheimer's disease has been like the search for the holy grail. While Alzheimer's science is advancing - every single clinical trial over the last 14 years has failed to produce a single successful new drug.One of the biggest problems is that Alzheimer's patients tend to decline at different rates. Show More Summary
The protein amyloid beta is believed to be the major cause of Alzheimer's disease. Substances that reduce the production of amyloid beta, such as BACE inhibitors, are therefore promising candidates for new drug treatments. Scientists have recently demonstrated that one such BACE inhibitor reduces the amount of amyloid beta in the brain. Show More Summary
For decades, researches have been investigating the underlying foundations of Alzheimer's disease to provide clues for the design of a successful therapy. Breakthrough insights reveal the molecular basis of the hereditary form of Alzheimer's disease that strikes early in life.
Pamela Kelley addresses the complex issue of what preparations we might be making for our own end of life, and for those living with Alzheimer's. She also takes on the issue of VSED - voluntary stopping eating and drinking for those with advanced dementia. Show More Summary
Findings by a team of researchers offer hope for the development of new therapies targeting cell loss in the brain associated with Alzheimer's disease Researchers lead byArizona State University-Banner Health neuroscientist Salvatore...Show More Summary
Researchers have captured the first three-dimensional snapshots of the AMPA-subtype glutamate receptor in action. The receptor, which regulates most electrical signaling in the brain, is involved in several important brain activities, including memory and learning.
Although dementia is most often seen in adults, childhood or adolescent dementia does occur. A team of researchers believes that established therapeutic drugs might be effective against childhood dementia.