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Novel biomarkers for future dementia risk

Medical researchers have identified novel biomarkers of risk for future dementia.

Enhancement of neurotrophic factor signaling may improve memory functions

Treatments targeted to enhance brain neurotrophic factor signaling could improve memory functions in Alzheimer's disease even though they don't alter brain amyloid burden, according to recent research.

'Epigenetic landscape' is protective in normal aging, impaired in Alzheimer's disease

Researchers profiled the epigenomic landscape of Alzheimer's brains, specifically in one of the regions affected early in AD, the lateral temporal lobe. They compared these to both younger and elderly cognitively normal control subjects. Show More Summary

Polygenic risk score may identify Alzheimer's risk in younger populations

For the first time, scientists have determined that an Alzheimer's disease (AD) polygenic risk score can be used to correctly identify adults with mild cognitive impairment (MCI) who were only in their 50s.

'Filter' hones GWAS results to help researchers avoid dead ends

A genetics research team has solved a dilemma facing researchers who use genomewide association studies (GWAS) by developing a new approach that strategically 'filters' which genes are worth further study. The researchers hope this strategy...Show More Summary

Stem-cell study points to new approach to Alzheimer's disease

Improving the trafficking of brain-cell proteins to reduce toxic buildup holds possibilities for new therapies against Alzheimer's disease.

A neuron can cause a domino effect

If the sense of smell disappears, this can indicate a disease such as Alzheimer's or Parkinson's disease. However, unlike previously assumed, general degenerations in the nervous system do not play a leading role in the loss of the sense of smell with increasing age, but individual nerve cells or classes of nerves are decisive.

ALS-linked protein's journey into nervous system cells more complex than we thought

Scientists have developed a better understanding of a key protein associated with brain diseases including ALS (motor neuron disease) and dementia by studying how it enters central nervous system cells.

Unpacking asymmetric cell division

Scientists have found a new role for proteins that play important roles in asymmetric division, which may play a role in tumor formation or neurodevelopmental disorders.

Early Stage Alzheimer’s Perspective

It isn't easy to identify early stage Alzheimer's, it is easy to rationalize their behaviors by simple believing they are getting old. By Elaine C Pereira Alzheimer's Reading Room Having lived my mother’s journey through Alzheimer’s,...Show More Summary

The onset of Alzheimer's disease: The importance of family history

A new study shows that the closer a person gets to the age at which their parent exhibited the first signs of Alzheimer's, the more likely they are to have amyloid plaques, the cause of the cognitive decline associated with the disease, in their brain.

How to Cope With Your Emotions When Your Loved One Has Hallucinations

A hallucination uccurs when a person sees, hears, feels, tastes, or smells something that isn’t there. by Marie Marley Alzheimer's Reading Room “Marie,” my life partner, Ed, shouted by phone from his memory care facility. “I was beaten...Show More Summary

Study finds alcohol use the biggest risk factor for dementia

Alcohol use disorders are the most important preventable risk factors for the onset of all types of dementia, especially early-onset dementia. by Alzheimer's Reading Room This study looked specifically at the effect of alcohol use disorders,...Show More Summary

Film Memento helped uncover how the brain remembers and interprets events from clues

In the Christopher Nolan film Memento (2000) the protagonist suffers from long-term memory loss and is unable to retain new memories for no longer than a few minutes. The events unfold in reversed chronological order. The results deepen...Show More Summary

Cellular recycling caught in the act

Researchers have observed a normal physiological process, called "self-eating", that cells use to recycle their components. They developed an accurate technique that visualizes how mitochondria, cells’ energy factories, are fused with lysosomes, cells’ recycling machines, in order to get material destroyed and recycled. Show More Summary

Sleep Medications for Alzheimer's and Dementia Patients

I often have family caregivers request medications to help people living with Alzheimer's and related dementia to sleep. By Rita Jablonski Alzheimer's Reading Room Medications have their place in Alzheimer's care, but only AFTER all of the suggestions listed below have been followed. Show More Summary

People with Alzheimer's Can Be Moody, Distrustful, Stubborn, Aggressive, Mean, and Discombobulated

People living with Alzheimer's or dementia can be moody, distrustful, stubborn, aggressive, and mean. Lets just say they become easily Discombobulated. by Bob DeMarco Alzheimer's Reading Room It is very difficult to understand people living with Alzheimer's and dementia. Show More Summary

Amyloid protein transmission through neurosurgery

Amyloid beta pathology -- protein deposits in the brain - might have been transmitted by contaminated neurosurgical instruments, suggests a new study. Researchers studied the medical records of four people who had brain bleeds caused by amyloid beta build-up in brain blood vessels. Show More Summary

Everyday activities associated with more gray matter in brains of older adults

Higher levels of lifestyle physical activity are associated with more gray matter in the brains of older adults, according to a new study.

Can Nicotinamide Riboside Help Prevent Alzheimer's?

The supplement nicotinamide riboside (NR) – a form of vitamin B3 – prevented neurological damage and improved cognitive and physical function in a new mouse model of Alzheimer’s disease. by Alzheimer's Reading Room The results of the...Show More Summary

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