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Death Rates from Alzheimer’s Disease Jump by 55 Percent How? Why?

By Bob DeMarcoAlzheimer's Reading RoomDeath rates from Alzheimer’s disease (AD) increased by 55 percent between 1999 and 2014, according to a study released by the Centers for Disease control and Prevention (CDC).The number of Alzheimer’s deaths at home also increased from 14 percent to 25 percent. Show More Summary

Rapid smell source localization: Mechanism discovered

Fundamental insights into the mechanism of smell localization have now been gained by researchers. This marks an important step in unraveling the entire neural odor localization mechanism, which is highly valuable to the study of memory diseases such as Alzheimer's. Show More Summary

Disrupted fat breakdown in the brain makes mice dumb

A new study opens a new perspective with regard to the development of dementia. The scientists blocked the breakdown of a certain fat molecule in the mouse brain. As a result the animals exhibited learning and memory problems. Also the quantity of Alzheimer-specific proteins in their brains increased significantly. The researchers now have a clue as to why the mice become dumb.

Tau prevents synaptic transmission at early stage of neurodegeneration

Tau proteins are involved in more than twenty neurodegenerative diseases, including various forms of dementia. These proteins clump together in patients’ brains to form neuronal tangles: protein aggregation that eventually coincides with the death of brain cells. Show More Summary

Flies the key to studying the causes of dementia

A research team has studied two structurally-similar proteins in the adult brain and have found that they play distinct roles in the development of dementia.

Patient's cells used to replicate dire developmental condition

A team of scientists has used the cells of AHDS patients to recreate not only the disease, but a mimic of the patient's blood-brain barrier in the laboratory dish using induced pluripotent stem cell technology.

What is survival among patients with Parkinson, Dementia with lewy bodies?

A new article compares survival rates among patients with synucleinopathies, including Parkinson disease, dementia with Lewy bodies, Parkinson disease dementia and multiple system atrophy with parkinsonism, with individuals in the general population.

Possible reasons for loss of smell

Studies have shown that loss of the sense of smell can be among the first warning signs of diseases such as Alzheimer's and Parkinson's. Now a researcher wants to shift the search for clues about this process back even further, to find...Show More Summary

Shortage of progranulin is a frequent cause of frontotemporal dementia

Researchers have revealed a novel function for progranulin in lysosomes: it acts as chaperone of the lysosomal protease cathepsin D.

In Huntington's disease, traffic jams in the cell's control center kill brain cells

Working with mouse, fly and human cells and tissue, researchers report new evidence that disruptions in the movement of cellular materials in and out of a cell's control center -- the nucleus -- appear to be a direct cause of brain cell death in Huntington's disease, an inherited adult neurodegenerative disorder.

Antibiotic doxycycline may offer hope for treatment of Parkinson's disease

Doxycycline, an antibiotic used for over half a century against bacterial infections, can be prescribed at lower doses for the treatment of Parkinson's disease, say researchers.

Overweight/obese people with diabetes at increased risk of brain abnormalities

Overweight and obese individuals with early stage type 2 diabetes (T2D) had more severe and progressive abnormalities in brain structure and cognition compared to normal-weight study participants, research indicates.

Low levels of 'memory protein' linked to cognitive decline in Alzheimer's disease

This discovery may lead to important research and may one day help experts develop new and better therapies for Alzheimer's and other forms of cognitive decline.

Brain stimulation restores memory during lapses, research shows

Electrical stimulation delivered when memory is predicted to fail can improve memory function in the human brain, a team of neuroscientists shows for the first time. That same stimulation generally becomes disruptive when electrical pulses arrive during periods of effective memory function.

Antibody helps detect protein implicated in Alzheimer's, other diseases

Damaging tangles of the protein tau dot the brains of people with neurodegenerative diseases like Alzheimer's and boxer's dementia. Now, a team of scientists has found a way to measure tau levels in the blood that accurately reflects levels of tau in the brain. The study, in mice and a small group of people, could be the first step towards a non-invasive test for tau.

Crucial 'traffic regulator' in neurons discovered by cell biologists

Cell biologists have discovered the protein that may be the crucial traffic regulator for the transport of vital molecules inside nerve cells. When this traffic regulator is removed, the flow of traffic comes to a halt. 'Traffic jams' are reported to play a key role in neurodegenerative diseases such as Alzheimer's and Parkinson's disease.

Homing in on plaque-causing protein in ALS and dementia

Scientists have made advances in understanding how damaging plaques build up in neurodegenerative illnesses like ALS and dementia.

Family History of Alzheimer’s May Alter Gene That Increases Risk of Alzheimer's

Does family history play a role in Alzheimer's disease? By Alzheimer's Reading Room I get asked this question all the time - if my dad or mom had Alzheimer's am I going to get it?The exact causes of Alzheimer's disease are not yet fully understood. Show More Summary

How to Understand and Foster Self Esteem in People Living with Dementia

Self esteem relates to confidence in one's own worth or abilities. By Marie Marley and Teepa Snow Alzheimer's Reading Room Self-esteem is defined as “a confidence and satisfaction in oneself.” Synonyms include:self-respect, self-regard, pride, dignity, morale, self-confidence, and self-assurance. Show More Summary

Are You a Good Dementia Detective?

If you are a good Dementia cop, you probably learned that your Alzheimer's patient is not guilty of a crime. If you are a bad Dementia cop, you are probably upset all the time by the behavior of your Alzheimer's patient. It is pretty...Show More Summary

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