Most of the Round of 16 ties in the 2012 Copa Libertadores don't kick off for another week, but two of them get underway on Wednesday. Three of the five Brazilian sides that have advanced are in action. One tie is a Brazilian-on-Brazilian clash, while the other features Neymar and Ganso leading their team into La Paz.
Bolivar vs. Santos FC
Wednesday, 8:50 p.m. ET
Santos FC are favorites to progress in this tie, but they'll need to limit the damage they suffer on Wednesday to take a decent aggregate score back home.