Post Profile






A Long-noncoding RNA Regulates Repair of DNA Breaks in Triple-Negative Breast Cancer Cells

Using a clinically guided genetic screening approach, researchers identified a non-coding RNA that is overexpressed in triple-negative breast cancer cells and regulated by the tumor suppressor p53 and the activated cell surface protein, EGFR. This molecule enhances the repair of DNA breaks by serving as a scaffold that links two other proteins in the repair machinery.
read more

share

Related Posts


Cancer Cells Aided By Enzyme To Avoid Genetic Instability

Health : Medical News Today

Cancer cells are resourceful survivors with plenty of tricks for staying alive. Researchers have uncovered one of these stratagems, showing how cells lacking the tumor suppressor BRCA1 can resume one form of DNA repair, sparing them...

Researchers Identify PHF20, A Regulator Of Gene P53, Critical For Normal Cell Growth And Tumor Suppression

Health : Medical News Today

Researchers at Moffitt Cancer Center and colleagues have identified PHF20, a novel transcriptional factor, and clarified its role in maintaining the stability and transcription of p53, a gene that allows for both normal cell growth ...

New Study Shows Promise for Preventing Therapy Resistance in Tumor Cells

Health : Newswise Medical News

A new study led by University of Kentucky researchers suggests that activating the tumor suppressor p53 in normal cells causes them to secrete Par-4, another potent tumor suppressor protein that induces cell death in cancer cells. T...

Development Of White Fat Cells Controlled By Long Noncoding RNAs

Health : Medical News Today

Whitehead Institute researchers have identified a previously unrecognized layer of genetic regulation that is necessary for the generation of undesirable white fat cells. When this regulation is disrupted, white fat cells are unable...

Discovered the role of noncoding 5S rRNA in protecting the p53 tumor suppressor gene

Academics / General Science : ScienceDaily: Science Society

Researchers have discovered a role for ribosomal 5S RNA in the formation of a complex that regulates the stability of p53. Normally, p53 prevents healthy cells from becoming tumorigenic.

Comments


Copyright © 2016 Regator, LLC