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Tapping evolution to improve biotech products

Scientists can improve protein-based drugs by reaching into the evolutionary past, a new paper proposes. As a proof of concept for this approach, the research team showed how "ancestral sequence reconstruction" or ASR can guide engineering of the blood clotting protein known as factor VIII, which is deficient in the inherited disorder hemophilia A.
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Scientists can improve protein-based drugs by reaching into the evolutionary past, a paper published in Nature Biotechnology proposes.


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