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Crosstalk analysis of biological networks for improved pathway annotation

Researchers at Stockholm University and Science for Life Laboratory have developed a new computer algorithm for analysing gene function called BinoX, which was e-published in Nucleic Acids Research on September 22 (Ogris et al., 2016a). The method, developed by Professor Erik Sonnhammer's research group, associates experimentally derived gene lists and known pathways. It does this in a new way, by employing a large gene network and determining if a gene list and a pathway has more network links than expected, using the binomial distribution.
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