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Specific inhibition of autophagy may represent a new concept for treatment of kidney cancer

Academics / General Science : Science Codex

CINCINNATI—New research at the University of Cincinnati (UC) suggests that kidney cancer growth depends on autophagy, a complex process that can provide cells with nutrients from intracellular sources. Researchers say in certain cir...

Dab2 regulates autophagy: New insights into mechanisms of chemo-resistance and metastasis

Academics / General Science : ScienceDaily: Science Society

Investigators report preclinical findings suggesting that disabled 2 (Dab2) serves as a molecular switch that regulates whether a tumor cell undergoes autophagy or apoptosis. Maintaining Dab2 by inhibiting cathepsin B could prevent ...

Potential New Treatment For Kidney Cancer By Specific Inhibition Of Autophagy

Health : Medical News Today

New research at the University of Cincinnati (UC) suggests that kidney cancer growth depends on autophagy, a complex process that can provide cells with nutrients from intracellular sources. Researchers say in certain circumstances ...

AACR news: Autophagy-addicted breast cancers killed by anti-malaria drug, chloroquine

Academics / General Science : Science Codex

The process of autophagy cleans cells – they wrap up the bad stuff and then dispose of it. And so it stands to reason that inhibiting autophagy would make cancer cells less able to cleanse themselves of chemotherapy and so more susc...

Stopping Cancer in Its Tracks

Health : Newswise Medical News

Inhibiting autophagy, the process cells use to degrade large intra-cellular cargo, effectively blocks tumor cell migration and breast cancer metastasis in tumor models. Metastasis is responsible for 90 percent of cancer deaths. Ther...

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