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Tumors Elude Anti-Cancer Drugs Through "Fork Reversal" Repair

Health : Newswise Medical News

Saint Louis University researchers found the first evidence that cancer cells' DNA replication machinery can react to drug treatment with a repair process called fork reversal.

Rockefeller scientists first to reconstitute the DNA 'replication fork'

Academics / General Science : Science Codex

When a cell divides, it must first make a copy of its DNA, a fundamental step in the life cycle of cells that occurs billions of times a day in the human body. While scientists have had an idea of the molecular tools that cells use ...

Eukaryote process of programmed fork arrest determined

Academics / General Science : ScienceDaily: Science Society

New research has revealed the means by which cells accomplish programmed DNA replication arrest. The work describes the conditions that require a replication fork to stop, and in doing so explain why terminator sites on DNA don't al...

Small molecule inhibitor shows promise in precision cancer targeting

Academics / General Science : ScienceDaily: Science Society

Cancer cells with BRCA1 or BRCA2 gene mutations are key targets for cancer therapeutics. Yet, few agents can selectively eliminate cells deficient in BRCA, and none can do so without the risk of inducing drug resistance. Now scienti...

Malignant cells adopt a different pathway for genome duplication

Academics / General Science : Science Codex

Genomes must be replicated in two copies during cell division. This process occurs at structures called 'replication forks', which are equipped with enzymes and move along the separated DNA strands. In tumour cells, the replication ...


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