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Buffalo Bills vs. New England Patriots Betting Odds, Analysis, NFL Pick

The New England Patriots (3-0) may not yet know who their starting quarterback will be Sunday when they host the Buffalo Bills in an AFC East matchup. But the Patriots are solid home favorites as they try to beat the Bills for the 24th time in 26 meetings with Tom Brady set to return in Week 5. Point spread: The Patriots opened as four-point favorites; the total was not available early in the week, according to sportsbooks monitored by Odds Shark.
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