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Use of a Mitochondrially Targeted Antioxidant Fails to Reduce Sarcopenia

Regular readers will be at least passingly familiar with the commercial development of mitochondrially targeted antioxidant compounds that has taken place over the past decade. This initially attracted attention in this community because the evidence suggests that these molecules can modestly slow the progression of aging, though unfortunately not to the same degree as interventions like calorie restriction, which to my eyes at least means that serious life extension efforts are better directed elsewhere.
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Reporting on a Recent Study of Mitochondrially Targeted Antioxidant SkQ1

Health / Aging : Fight Aging

Here, researchers report on a recent study of the ability of mitochondrially targeted antioxidants to modestly increase healthy life span in lower animals such as the flies used here. Mitochondria are important in the progression of...

Mitochondrially Targeted Antioxidant SS-31 Reverses Some Measures of Aging in Muscle

Health / Aging : Fight Aging

Antioxidants of the sort you can buy at the store and consume are pretty much useless: the evidence shows us that they do nothing for health, and may even work to block some beneficial mechanisms. Targeting antioxidant compounds to ...

More Robust Data on the Effect of Mitochondrially Targeted Antioxidants on Fly Life Span

Health / Aging : Fight Aging

In recent years a few research groups have been working on a class of antioxidant compounds that can be ingested but nonetheless target themselves to mitochondrial in our cells. These compounds extend life in laboratory animals, pro...

The Slow Progression of Mitochondrially Targeted Antioxidants

Health / Aging : Fight Aging

It was going on a decade ago that I first noticed research on antioxidant compounds that target mitochondria in cells. That was the Russian research team of Vladimir Skulachev and their family of plastinquinone compounds, with SkQ a...

Commercialization of Mitochondrially Targeted Antioxidant Plastinquinones Continues, Slowly

Health / Aging : Fight Aging

Mitochondrially targeted antioxidant compound SkQ1, a plastinquinone, has at this point been moving through the commercial development pipeline for a decade or so. This is par for the course in medicine, sad to say. Engaging with th...


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