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Blocking key gene reduces cigarette smoke toxicity in fish embryos

(Duke University) A Duke University-led study shows how exposure to the particulate matter from cigarette smoke may affect early development in zebrafish embryos and increases the risk of neurological disorders and physical deformities. Injecting early-stage embryos with a molecule to block a specific gene's activity gene led to fewer deformities; but blocking two associated enzymes -- CYP1A and CYP1B1 -- exacerbated deformities.
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