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Future therapeutics: Drugs that stop free radicals at their source

(Buck Institute for Research on Aging) Researchers at the Buck Institute have stopped free radicals from being produced at their source. The findings may explain why antioxidants have failed to show benefits in human clinical trials and provides a way to take a fresh look at the 'free radical theory of aging.' The work yielded molecules that prevented free radical production in cell culture, isolated hearts, and live models of disease with striking results in a mouse heart model of ischemia.
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