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Absolute structure determination: Pushing the limits

(International Union of Crystallography) It was the Softenon disaster that made the pharmaceutical industry fully aware of the importance of knowing the enantiomeric purity and chirality of drugs and their metabolites. This disaster involved the chiral drug Thalidomide that was sold in the 1950s as a racemate under various brand names such as Contergan and Softenon.
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