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New treatment approach for leukemia renders cancer genes powerless

(Johannes Gutenberg Universitaet Mainz) In leukemia cells it is often the case that genes are reactivated that, in physiological terms, mediate the self-renewal of blood stem cells. In a common subtype of acute myeloid leukemia, this abnormal activation of such self-renewing genes is apparently caused by structural modifications of the DNA packaging. In turn, these modifications are caused by two specific proteins of the so-called chromatin regulator group, on which leukemia cells are dependent.
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