Post Profile

Fetal liver endothelium regulates the seeding of tissue-resident macrophages

Macrophages are required for normal embryogenesis, tissue homeostasis and immunity against microorganisms and tumours. Adult tissue-resident macrophages largely originate from long-lived, self-renewing embryonic precursors and not from haematopoietic stem-cell activity in the bone marrow. Although fate-mapping studies have uncovered a great amount of detail on the origin and kinetics of fetal macrophage development in the yolk sac and liver, the molecules that govern the tissue-specific migration of these cells remain completely unknown.
read more


Related Posts

Infections Can Trigger Hematopoiesis At Sites Outside The Bone Marrow - In The Liver, The Spleen Or The Skin

Health : Medical News Today

Balanced hematopoiesis is essential for the function of the immune system. During fetal development, hematopoiesis takes place mainly in the liver and the spleen. Later the process is delegated to the bone marrow, and this tissue no...

Cells Too Stiff to Scavenge Leads to Lupus, an Autoimmune Disease

Health : Newswise Medical News

Macrophage cells require agility to scavenge and digest dead cells and prevent an immune response to self. In lupus, the macrophages lose that agility.

A Novel Method Of Isolating High Quality RNA From Kupffer Cells

Health : Medical News Today

Kupffer cells, resident tissue macrophages that line the liver sinusoids, play a key role in modulating inflammation in a number of experimental models of liver injury. Since Kupffer cells represent only a small portion of the entir...

Adult Stem Cells Take Root in Livers and Repair Damage

Health : Newswise Medical News

Johns Hopkins researchers have demonstrated that human liver cells derived from adult cells coaxed into an embryonic state can engraft and begin regenerating liver tissue in mice with chronic liver damage.

Research paves way for monocyte based cell therapy

Academics / General Science : ScienceDaily: Science Society

Adult circulating monocytes that get access to the macrophage niche in the liver or the lung can acquire identical tissue-specific macrophage functions and self-maintenance capacities as macrophages of embryonic origin, scientists h...


Copyright © 2016 Regator, LLC