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Novel target for diabetes drug identified as ion exchanger

Nagoya University-led researchers use nematode worms as a model to identify a new target of the type 2 diabetes drug metformin; ion exchanger protein NHX-5 and its related protein in fruit flies are potential metformin targets, suggesting the drug controls the cellular endocytic cycle.
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(Nagoya University) Researchers led by Nagoya University identified the ion exchanger protein NHX-5 as a novel molecular target of the type 2 diabetes drug metformin in a soil-dwelling model organism, the nematode worm. NHX-5 is fou...

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