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Novel target for diabetes drug identified as ion exchanger

(Nagoya University) Researchers led by Nagoya University identified the ion exchanger protein NHX-5 as a novel molecular target of the type 2 diabetes drug metformin in a soil-dwelling model organism, the nematode worm. NHX-5 is found in membranes of cellular transport sacs (endosomes), and helps regulate the endosomal cycle. These findings aid understanding of the actions of drugs for diabetes, and may help in development of new therapies for this and other metabolic disorders.
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