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Researchers find two distinct genetic subtypes in Crohn's disease patients

(University of North Carolina Health Care) Crohn's disease, a common inflammatory disorder of the intestinal tract, can have devastating consequences and is notoriously hard to treat successfully, in part because its course and severity vary so much from one case to the next. Now, UNC scientists have made a discovery that could explain why Crohn's is so variable: the disease appears to have at least two distinct subtypes, each with its own pattern of gene expression and mix of clinical features.
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