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San Francisco 49ers vs. Buffalo Bills Betting Odds, Analysis, NFL Pick

The San Francisco 49ers will be looking to end a four-game straight-up and against-the-spread losing streak when they visit the Buffalo Bills on Sunday. The 49ers have surrendered 35 points per game since opening with a 28-0 win over Los Angeles and are a 1-9 SU and 2-8 ATS in their past 10 road contests. The Bills have claimed decisive victories in three straight games, including two outright wins as betting underdogs, and they are 14-2 SU and 10-6 ATS in their past 16 games when favored by nine or more points.
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