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Oncoproteins interact to promote cancer cell growth in retinoblastoma

(Children's Hospital Los Angeles) Researchers at The Saban Research Institute of Children's Hospital Los Angeles have identified an unsuspected and critical role of the MDM2 oncogene in promoting expression of the MYCN oncogene that is required for growth and survival of retinoblastoma cells. Their results are published in the Oct. 17 online edition of the Nature journal Oncogene.
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An unsuspected and critical role of the MDM2 oncogene has been uncovered in promoting expression of the MYCN oncogene that is required for growth and survival of retinoblastoma cells.

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