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Two studies describe the function of PrPc, the 'good' alter ego of prions

Two new studies coordinated by SISSA reveal important details about the physiological function of the prion protein, the non-pathological form of the notorious prion, the degenerate protein responsible for several diseases including "mad cow disease." According to the new findings, the protein in its physiological form serves the important function of promoting the growth of neurites, the neural projections along which nerve impulses travel.
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From good to bad with a copper switch

Academics / General Science : Science Codex

At the molecular level, the difference between Doctor Jekyll and Mr Hyde lies in a metal, copper. In its physiological form, the prion protein (PrPC ) is 'good' and is involved in normal body processes. It can happen, however, that ...

New approach to protecting prion protein from altering shape, becoming infectious

Academics / General Science : ScienceDaily: Science Society

Scientists have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases.

Prion protein can trigger spongiform encephalopathy and neurodegeneration

Health : Medical News Today

Transmissible spongiform encephalopathy or prion disease is triggered by the conversion from cellular prion protein to pathogenic prion protein. Notably, C-transmembrane form of prion protein and cytosolic prion protein can result i...

Prion protein protects against epilepsy

Academics / General Science : ScienceDaily: Science Society

In the most systematic and rigorous study conducted thus far in its field, the prion protein (PrPC) was clearly shown to play a role in preventing the onset of epileptic seizures. PrPC is perhaps best known in its 'degenerate' form,...

Two studies describe the function of PrPC, the 'good' alter ego of prions

Health : EurekAlert: Health

(International School of Advanced Studies (SISSA)) Two new studies coordinated by SISSA reveal important details about the physiological function of the prion protein, the non-pathological form of the notorious prion, the degenerate...

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