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Vulnerabilities of leukemia cells revealed using genome editing technique

(Wellcome Trust Sanger Institute) Researchers from the Wellcome Trust Sanger Institute and their collaborators have adapted a CRISPR gene editing technique and used it to find new therapeutic targets for acute myeloid leukemia (AML). In research published in Cell Reports, the team identify a large number of genes that could serve as potential targets for anti-AML treatments and describe how inhibition of one of these genes, KAT2A, destroys AML cells without harming non-leukemic blood cells.
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