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Using RNA Regulation to Argue for the Relevance of Transposons in Aging

Of late a number of research groups have argued that transposon activity is a contributing cause of dysfunction in aging. Transposons are sections of genetic material that can move around within the genome, and more of this moving around occurs with advancing age, taking place in a more or less random manner within individual cells. The discussion over whether and why this can be a significant cause of aging is similar to that for stochastic mutational damage in nuclear DNA.
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Discovery Of Specific Small RNA Pathways That Protect Germ Line From Transposons

Health : Medical News Today

In the fruit fly ovary, germ line and somatic cells use different piRNA pathways in transposon defense Cells of higher organisms are in a constant struggle against some of their own DNA - repeated bits of DNA sequence called transpo...

Genome Evolution May Be Influenced By A 'Jumping Gene's' Preferred Targets

Health : Medical News Today

The human genome shares several peculiarities with the DNA of just about every other plant and animal. Our genetic blueprint contains numerous entities known as transposons, or "jumping genes," which have the ability to move from pl...

Considering Transposons and Neurodegeneration in Aging Flies

Health / Aging : Fight Aging

You might recall a recent article on transposons as a form of more aggressive genetic damage and disarray in the later stages of aging. It is unclear as to whether this is a secondary effect or whether it does in fact contribute to ...

A 'jumping gene's' preferred targets may influence genome evolution

Academics / General Science : ScienceDaily: Science Society

Our genetic blueprint contains numerous entities known as transposons, which have the ability to move from place to place on the chromosomes within a cell. An astounding 50 percent of human DNA comprises both active transposon eleme...

More Evidence of a Role for Transposons in Aging

Health / Aging : Fight Aging

Of late researchers have been investigating a possible role for transposable elements, or transposons, in degenerative aging. These are DNA sequences that can move around in the genome, and the incidence of such movement increases w...

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