Post Profile

CDK4/6 inhibition triggers anti-tumour immunity

Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies. Pharmacological inhibitors of CDK4/6 have shown significant activity against several solid tumours. Their primary mechanism of action is thought to be the inhibition of phosphorylation of the retinoblastoma tumour suppressor, inducing G1 cell cycle arrest in tumour cells.
read more


Related Posts

Roche's XCELLigence System Offers Dynamic And Label-free Assessing Of Kinase Activity In Living Cells

Health : Medical News Today

The central role of receptor tyrosine kinases (RTKs) in cellular processes, especially in cancer, has made them an important target for several antibody- and small molecule-based inhibitors specific for various RTKs for the treatmen...

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

Academics : Nature AOP

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor that is upregulated on activated T cells for the induction of immune tolerance. Tumour cells frequently overexpress the ligand for PD-1, programmed cell death l...

Cell cycle: Division enzyme regulates metabolism

Academics : Nature AOP

Cell division requires the action of key regulator proteins called cyclins and CDKs. It emerges that a cyclin–CDK complex can regulate cell metabolism, and targeting this metabolic regulation causes tumour regression in mice.

Cell Cycle-Blocking Drugs Can Shrink Tumors by Enlisting Immune System in Attack on Cancer, Study Finds

Health : Newswise Medical News

Study explains why CDK4/6 inhibitors can shrink tumor in some advanced breast cancers CDK4/6 inhibitors trigger the immune system to attack tumor cells CDK4/6 inhibitors can also enhance anti-cancer effect of immunotherapy agents

The metabolic function of cyclin D3–CDK6 kinase in cancer cell survival

Academics : Nature AOP

D-type cyclins (D1, D2 and D3) and their associated cyclin-dependent kinases (CDK4 and CDK6) are components of the core cell cycle machinery that drives cell proliferation. Inhibitors of CDK4 and CDK6 are currently being tested in c...


Copyright © 2016 Regator, LLC