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Gene variant activity is surprisingly variable between tissues

(CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences) Every tissue has its own pattern of active alleles, a large-scale study led by an international team of scientists at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has found. Researchers of the former group of Denise Barlow were able to show that the differential allele activity is regulated by tissue-specific, regulatory DNA elements known as enhancers - a process that could also be involved in many diseases.
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