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Researchers examine how opioids affect proteins in the brain other than opioid receptors

In a new study, researchers have characterized the effects of a series of opioids on proteins in the brain other than opioid receptors. In the British Journal of Pharmacology study, several synthetic opioids inhibited serotonin and norepinephrine transporters, which may contribute to their analgesic properties but may also increase the risk of serotonin toxicity, a group of symptoms that can include high body temperature, agitation, increased reflexes, tremor, sweating, dilated pupils, and diarrhoea.
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