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ANGPTL2 Knockout Reduces Inflammation and Slows Muscle Loss in Mice

The gene ANGPTL2 is starting to look like an interesting basis for therapy, something to bump closer to the top of the lengthy list of targets to consider for first generation human gene therapies. In animal studies, lowering the level of protein produced by this gene has been shown to reduce chronic inflammation in older individuals and slow progression towards heart failure, effects that might be mediated through an influence on the presence of senescent cells in the cardiovascular system.
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