Fibrosis is a common pathology in cardiovascular disease. In the
heart, fibrosis causes mechanical and electrical dysfunction and
in the kidney, it predicts the onset of renal failure. Transforming
growth factor ?1 (TGF?1) is the principal pro-fibrotic
factor, but its inhibition is associated with side effects
due to its pleiotropic roles. We hypothesized that downstream
effectors of TGF?1 in fibroblasts could be attractive therapeutic
argets and lack upstream toxicity.
Elderly with chronic kidney disease face higher coronary heart disease, heart failure, or stroke risk. You may not necessarily think about the link between the kidneys and the heart, but the two actually share many risk factors whic...
A new study suggests that two tests commonly used in the assessment of chronic kidney disease could also be used to predict the risk of cardiovascular disease.
Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen. In a recent study, researchers have shown that drugs that target Wnt secretion by inhibitin...
Renal fibrosis or the scarring of kidneys, following an injury, reduces their function and can cause kidney disease to progressively worsen. In a recent study, published in Kidney International, researchers from Duke-NUS Medical Sch...