Dragons give half-backs Arwel Robson and Dan Babos their European debuts against Enisei-STM, and rest their Wales squad members.
Darcy Graham starts at full-back in one of eight changes for Edinburgh for their final Challenge Cup pool match against Stade Francais.
Team news for Connacht against Oyonnax in their European Challenge Cup fixture at the Sportsground (14:30 GMT).
Team details and match preview as Dragons host Bordeaux-Begles in the European Challenge Cup on Saturday.
Cardiff Blues make six changes for the Challenge Cup trip to face Lyon with Wales squad prop Dillon Lewis starting and Josh Navidi switching to number eight.