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Could viruses take cancer immunotherapy to the next level?

(The Ottawa Hospital) Immunotherapy, which helps the body's immune system attack cancer, has revolutionized treatment for cancers such as melanoma and leukemia. However, many other kinds of cancer remain resistant. A new study suggests that a combination of two immunotherapies (oncolytic viruses and checkpoint inhibitors) could be much more successful. This combination could cure 60-90 percent of mice in aggressive breast cancer models.
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(Alliance for Cancer Gene Therapy) A study published in Science Translational Medicine shows a combination of oncolytic viruses and checkpoint inhibitors successfully treated breast cancer with a 60-90 percent cure rate.

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(University of Leeds) Virus could act as an immunotherapy when injected into bloodstream. First human trial shows virus can cross blood-brain barrier to infect tumors and stimulate the body's immune system to attack the cancer.


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