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Towards Therapies Based on Klotho

Klotho is one of the few definitively longevity-associated genes. The protein it produces is associated with a range of important processes, though its roles are far from fully understood. Evidence exists for increased klotho to improve stem cell function, enhance cognitive function and increase synaptic plasticity in older animals, though whether or not this extends to humans is a question yet to be resolved.
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Klotho Influences Cognition as Well as Aging

Health / Aging : Fight Aging

A web of correlations exist between wealth, education, intelligence, and natural variations in human longevity. It is thus interesting to see that one of the genes associated with longevity and aging also has an effect on cognition ...

Medical News Today: Gene therapy may protect brain from age-related cognitive decline

Health : Medical News Today

One dose of a gene therapy that raises levels of the protein Klotho in the brain protected younger mice against age-related cognitive decline.

Researchers identify patterns of protein synthesis associated with increased longevity

Health : EurekAlert: Health

(Boston University Medical Center) Aging is a complex process that involves multiple metabolic and regulatory pathways. Previous studies have identified hundreds of genes whose deletion can significantly increase lifespan in model o...

Considering Klotho Delivery as a Means to Reduce Age-Related Stem Cell Decline

Health / Aging : Fight Aging

Today I'll point out an open access paper on the longevity-related gene klotho. Some researchers see therapies to adjust levels of the klotho protein produced from this genetic blueprint as a possible way to slow some of the effects...

More on Klotho and Neurodegeneration

Health / Aging : Fight Aging

High levels of the protein produced by the klotho gene are associated with longevity in mammals, and recently it has also been associated with greater cognitive performance. Here is another small piece of evidence to add to all that...


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