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Total Synthesis of ent-Ascospiroketal B

Original synthetic route to tricyclic natural product
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Targeted synthesis of natural products with light

Academics / General Science : ScienceDaily: Science Society

Photoreactions are essential for the syntheses of many natural substances. Since many of these substances are also useful as active medical agents, chemists try to produce them synthetically. But in most cases only one of the possib...

From Natural Product to Pharmaceutical.

Academics / Chemistry : Chemistry Blog

In a recent discussion (Nicolau), about the suggested move of Prof. NicoIau from Scripps, the issue of the practicality of natural product total synthesis was raised. Here is a wonderful example of just that very usefulness, a wonde...


Academics / Chemistry : Chemistry Blog

Macrolactonization: Now here is a word to strike fear into the heart of any synthetic organic chemist. It’s usually the last step, or one of the last steps in a long complicated natural product synthesis. [...]

Researchers systematize the methods for synthesis of azocine-containing systems

Academics / Chemistry : Physorg: Chemistry

The search for synthetic routes for new drugs plays an extremely important role in contemporary medicinal chemistry. Organic chemists from Russia conducted a systematic study of modern advances in the methods for the synthesis of an...

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors

Academics : Nature

Antimalarial drugs have thus far been chiefly derived from two sources—natural products and synthetic drug-like compounds. Here we investigate whether antimalarial agents with novel mechanisms of action could be discovered using a d...


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