(University of California - San Diego) Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer's, Parkinson's, schizophrenia and bipolar disorder. Show More Summary
This past decade, Alzheimer's science has undergone a paradigm shift toward the disease's early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What's the progress?
Research of the Week Canola oil worsens memory and learning in mice with Alzheimer’s disease. When the Inuit began “markedly increas[ing]” their sugar and refined carb intake, diabetes and heart disease shot up. Keto without exercise...Show More Summary
47 million Americans already demonstrate some evidence of susceptibility to Alzheimer's disease. By Alzheimer's Reading Room About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from...Show More Summary
Researchers report on the first large-scale longitudinal imaging study to evaluate BACE1 inhibition with micro-PET in mouse models of Alzheimer's disease. PET imaging has been established as an excellent identifier of the amyloid plaque and tau tangles that characterize Alzheimer's disease. Now it is proving to be an effective way to gauge treatment effectiveness.
Mitochondria, the power plants of the cell, suffer a general malaise in older individuals. Their dynamics change and their production of energy store molecules declines. This is distinct and separate from the damage to mitochondrialShow More Summary
Canola is generally considered a healthy oil thanks to its ability to reduce LDL cholesterol in the blood and lower the risk of heart disease. A new animal study out of Temple University, though, has shown that the vegetable-based fat...Show More Summary
A diet supplemented with canola oil worsened memory and led to weight gain in mouse models of Alzheimer's disease, researchers report.
Using genetic information, researchers provide new evidence that higher educational attainment is strongly associated with a lower risk of Alzheimer’s disease.
Researchers have shown that hyperbaric oxygen therapy alleviates some physical and behavioral symptoms of Alzheimer's in a mouse model of the disease.
On this week’s podcast, the “Outlander” star tells the story of a grandmother with Alzheimer’s and how the disease filtered her family’s world.
People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta. The findings indicate that APOE could potentially be a real target for treatment or prevention.
(University of Cambridge) The theory that education protects against Alzheimer's disease has been given further weight by new research from the University of Cambridge, funded by the European Union. The study is published today in The BMJ.
Jerome Crowe, a former L.A.-based FBI agent who delivered the ransom money in the Frank Sinatra Jr. kidnapping and led a SWAT team in the bloody SLA shootout, has died after a long struggle with Alzheimer’s disease. A lifelong law enforcement officer who is credited with assembling the FBI’s first...
Using a bioinformatics and experimental approach, scientists have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer's disease.
People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta. Show More Summary
A new study indicates that hyperbaric oxygen treatments may mitigate symptoms of Alzheimer's disease. By Alzheimer's Reading Room "This revolutionary treatment for Alzheimer's disease uses a hyperbaric oxygen chamber, which has been shown in the past to be extremely effective in treating wounds that were slow to heal," says Prof. Show More Summary
A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease. The molecule, called anle138b, works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer's and other neurodegenerative diseases such as Parkinson's and ALS.
Australian Synchrotron X-ray and infrared imaging techniques have been used in a powerful combined approach to characterise the composition of amyloid plaques that are associated with Alzheimer's disease.
(IOS Press) Trace elements of lithium in drinking water can slow death rates from Alzheimer's disease,Brock University research has found.Rates of diabetes and obesity, which are important risk factors for Alzheimer's disease, alsodecrease if there is a particular amount of lithium in the water, says the study, publishedrecently in the Journal of Alzheimer's Disease.