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Updated brain cell map connects various brain diseases to specific cell types

(University of California - San Diego) Researchers have developed new single-cell sequencing methods that could be used to map the cell origins of various brain disorders, including Alzheimer's, Parkinson's, schizophrenia and bipolar disorder. Show More Summary

Clinical Trials on Alzheimer's Disease: Shifting the Focus to Prevention

This past decade, Alzheimer's science has undergone a paradigm shift toward the disease's early, silent phase. For trials, this means change at every level: new participants, new screening tools, new outcome measurements. What's the progress?

Weekend Link Love — Edition 481

Research of the Week Canola oil worsens memory and learning in mice with Alzheimer’s disease. When the Inuit began “markedly increas[ing]” their sugar and refined carb intake, diabetes and heart disease shot up. Keto without exercise...Show More Summary

Those Living with Alzheimer's Will More Than Double by 2060

47 million Americans already demonstrate some evidence of susceptibility to Alzheimer's disease. By Alzheimer's Reading Room About 15 million Americans will have either Alzheimer’s dementia or mild cognitive impairment by 2060, up from...Show More Summary

PET tracer gauges effectiveness of promising Alzheimer's treatment

Researchers report on the first large-scale longitudinal imaging study to evaluate BACE1 inhibition with micro-PET in mouse models of Alzheimer's disease. PET imaging has been established as an excellent identifier of the amyloid plaque and tau tangles that characterize Alzheimer's disease. Now it is proving to be an effective way to gauge treatment effectiveness.

Boosting Mitochondrial Function Reduces Plaque and Improves Cognitive Function in a Mouse Model of Alzheimer's Disease

2 days agoHealth / Aging : Fight Aging

Mitochondria, the power plants of the cell, suffer a general malaise in older individuals. Their dynamics change and their production of energy store molecules declines. This is distinct and separate from the damage to mitochondrialShow More Summary

Canola oil linked to Alzheimer's complications in new study

2 days agoTechnology / Gadgets : Gizmag

Canola is generally considered a healthy oil thanks to its ability to reduce LDL cholesterol in the blood and lower the risk of heart disease. A new animal study out of Temple University, though, has shown that the vegetable-based fat...Show More Summary

Medical News Today: Canola oil may worsen memory

A diet supplemented with canola oil worsened memory and led to weight gain in mouse models of Alzheimer's disease, researchers report.

Genes behind higher education linked to lower risk of Alzheimer’s

Using genetic information, researchers provide new evidence that higher educational attainment is strongly associated with a lower risk of Alzheimer’s disease.

Medical News Today: Could an existing oxygen therapy treat Alzheimer's?

Researchers have shown that hyperbaric oxygen therapy alleviates some physical and behavioral symptoms of Alzheimer's in a mouse model of the disease.

Modern Love Podcast: Caitriona Balfe Reads ‘A Boyfriend Too Good to Be True’

4 days agoHealth : Well

On this week’s podcast, the “Outlander” star tells the story of a grandmother with Alzheimer’s and how the disease filtered her family’s world.

Alzheimer's damage in mice reduced with compound that targets APOE gene

People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta. The findings indicate that APOE could potentially be a real target for treatment or prevention.

Genetics study adds further evidence that education reduces risk of Alzheimer's disease

(University of Cambridge) The theory that education protects against Alzheimer's disease has been given further weight by new research from the University of Cambridge, funded by the European Union. The study is published today in The BMJ.

Jerome Crowe, the FBI agent who delivered the ransom money in the Frank Sinatra Jr. kidnapping, dies at 93

Jerome Crowe, a former L.A.-based FBI agent who delivered the ransom money in the Frank Sinatra Jr. kidnapping and led a SWAT team in the bloody SLA shootout, has died after a long struggle with Alzheimer’s disease. A lifelong law enforcement officer who is credited with assembling the FBI’s first...

Healthy mitochondria could stop Alzheimer's

Using a bioinformatics and experimental approach, scientists have found that rendering mitochondria resistant to damage can halt diseases caused by amyloid toxicity, such as Alzheimer's disease.

Alzheimer's Damage in Mice Reduced with Compound That Targets APOE Gene

People who carry the APOE4 genetic variant face a substantial risk for developing Alzheimer's disease. Now, researchers at Washington University School of Medicine in St. Louis have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer's protein amyloid beta. Show More Summary

Hyperbaric oxygen therapy may alleviate symptoms of Alzheimer's disease

A new study indicates that hyperbaric oxygen treatments may mitigate symptoms of Alzheimer's disease. By Alzheimer's Reading Room "This revolutionary treatment for Alzheimer's disease uses a hyperbaric oxygen chamber, which has been shown in the past to be extremely effective in treating wounds that were slow to heal," says Prof. Show More Summary

Experimental drug blocks toxic ion flow linked to Alzheimer's disease

A new small-molecule drug can restore brain function and memory in a mouse model of Alzheimer's disease. The molecule, called anle138b, works by stopping toxic ion flow in the brain that is known to trigger nerve cell death. Scientists envision that this drug could be used to treat Alzheimer's and other neurodegenerative diseases such as Parkinson's and ALS.

Combined imaging approach characterises plaques associated with Alzheimer's disease

Australian Synchrotron X-ray and infrared imaging techniques have been used in a powerful combined approach to characterise the composition of amyloid plaques that are associated with Alzheimer's disease.

Lithium in water associated with slower rate of Alzheimer's disease deaths

(IOS Press) Trace elements of lithium in drinking water can slow death rates from Alzheimer's disease,Brock University research has found.Rates of diabetes and obesity, which are important risk factors for Alzheimer's disease, alsodecrease if there is a particular amount of lithium in the water, says the study, publishedrecently in the Journal of Alzheimer's Disease.

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