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RIPK1 as a Target to Reduce Microglial Dysfunction in Alzheimer's Disease

5 hours agoHealth / Aging : Fight Aging

One component of most neurodegenerative diseases is that classes of immune cells resident in the brain adopt disruptive, inflammatory behaviors. This is a reaction in some way to growing levels of damage in the form of aggregated proteins, such as amyloid-? and tau in Alzheimer's disease, but it isn't a helpful reaction. Show More Summary

Scientists say AI can predict Alzheimer’s a decade before symptoms show

Researchers from the University of Bari in Italy have created algorithms that can analyze MRI scans to identify structural changes in the brain that signify a person is afflicted with the disease, reports the Times. Unlike human doctors, the AI doesn’t need to specifically be told to looks for signs of Alzheimer’s in brain scans. Show More Summary

Long-Term Gum Disease Linked To Alzheimer's Disease

People with chronic gum inflammation for 10 or more years were 70 percent more likely than people without periodontitis to develop Alzheimer’s disease.

Medical News Today: Alzheimer's disease: New genetic culprit found

A new study challenges the traditional understanding of Alzheimer's disease, as scientists point to a new gene that may be responsible for the illness.

Addressing the Daily Dilemmas of Dementia Care

On Friday, Sept. 22, UCI MIND and Alzheimer's Orange County will co-host the 28th Annual Southern California Alzheimer's Disease Research Conference, themed "The Elephant in the Room: Sensitive Subjects in Dementia Care." It will highlight...Show More Summary

Differences in aggression among people with dementia

Physical aggression among people with dementia is not unusual. A study showed that one-third of patients with the diagnosis Alzheimer’s disease or frontotemporal dementia were physically aggressive towards healthcare staff, other patients, relatives, animals and complete strangers. This manifestation of disease must be both understood and addressed in the right way.

Is the Alzheimer's gene the ring leader or the sidekick?

Scientific literature in recent years has focused extensively on one genetic risk factor for Alzheimer's disease, the ApoE4 gene variant. A recent study raises flags that scientists should investigate another important player, the TOMM40 gene.

Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease

A new study shows that hypometabolism in the medial prefrontal areas is specifically associated with Alzheimer's disease-related nutritional problems, and decrease in fat mass may have a key role.

Decreased glucose metabolism in medial prefrontal areas is associated with nutritional status in patients with prodromal and early Alzheimer's disease

(IOS Press) Obu, Japan, September 15, 2017 - A new study from the Multimodal Neuroimaging for AD Diagnosis (MULNIAD) study, which is a prospective study implemented at the National Center for Geriatrics and Gerontology (NCGG), provides...Show More Summary

Environmental Factors in Development of Alzheimer’s Disease

Alzheimer’s disease is one of those conditions where genetics is known to play a profound role but is not the sole factor in disease development and progression. The evidence is mounting that the environment has a great deal to do with the development of this neurodegenerative disorder. Moreover, it is now known that the right […]

Is the Alzheimer's gene the ring leader or the sidekick?

The notorious genetic marker of Alzheimer's disease and other forms of dementia, ApoE4, may not be a lone wolf. Researchers from USC and the University of Manchester have found that another gene, TOMM40, complicates the picture. Although ApoE4 plays a greater role in some types of aging-related memory ability, TOMM40 may pose an even greater risk for other types.

Is the Alzheimer's gene the ring leader or the sidekick?

(University of Southern California) Scientific literature in recent years has focused extensively on one genetic risk factor for Alzheimer's disease, the ApoE4 gene variant. A recent study published in PLOS ONE raises flags that scientists should investigate another important player, the TOMM40 gene.

AI spots Alzheimer’s brain changes years before symptoms emerge

A machine-learning algorithm that examines MRI scans can identify alterations in how different regions of the brain are connected that indicate future disease

8th Annual Conference on Alzheimer's Drug Discovery Showcases Non-Amyloid Research

/PRNewswire-USNewswire/ -- Nearly 200 academic and industry researchers came together to share updates on preclinical and clinical-stage Alzheimer's disease research at the 18th Annual Conference on Alzheimer's Drug Discovery. The two-day...Show More Summary

Differences in aggression among people with dementia

(Lund University) Physical aggression among people with dementia is not unusual. A study from Lund University in Sweden showed that one-third of patients with the diagnosis Alzheimer's disease or frontotemporal dementia were physically aggressive towards healthcare staff, other patients, relatives, animals and complete strangers. Show More Summary

Alzheimer's disease biomarker identified across test sites

(Mary Ann Liebert, Inc./Genetic Engineering News) A new study has demonstrated the potential to use a frequency distribution-based index of brain functional connectivity as a biomarker for detecting Alzheimer's disease and mild cognitive impairment.

Doctors Can Now Predict the Severity of Your Disease by Measuring Molecules

The simple new technique could offer vastly superior predictions of disease severity in a huge range of conditions with a genetic component, including Alzheimer's, autism, cancer, cardiovascular disease, diabetes, obesity, schizophrenia and depression.

Doctors can now predict the severity of your disease by measuring molecules

(University of Virginia Health System) The simple new technique could offer vastly superior predictions of disease severity in a huge range of conditions with a genetic component, including Alzheimer's, cancer, cardiovascular disease, diabetes, obesity, schizophrenia and depression.

Sharpest image of Alzheimer's fibrils shows previously unknown details

A team of researchers has determined the structure of an amyloid fibril with previously unachieved resolution. The fibrils of the body's own amyloid beta protein are the main constituent of Alzheimer's disease related and characteristic pathological protein deposits in the brain. Show More Summary

New diagnosis for Alzheimer's

In the largest and most conclusive study of its kind, researchers have analyzed blood samples to create a novel and non-invasive way of helping to diagnose Alzheimer's disease and distinguishing between different types of neurodegenerative disorders. Show More Summary

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