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Novel classification can lead to new ways to diagnose and treat cancer

(Baylor College of Medicine) A novel approach to studying cancer has enabled researchers to group about 10,000 human cancers of 32 different types into 10 classes based on the molecular pathways that drive tumor growth. A better understanding of these pathways can potentially lead to novel ways to diagnose and treat cancer.

Researchers identify gene largely accounting for 15q13.3 microdeletion syndrome

(Baylor College of Medicine) Researchers have identified in a mouse model OTUD7A as the gene within the deleted region that accounts for many characteristics of 15q13.3 microdeletion syndrome.

Schistosoma Vaccine to Enter Phase Ib Clinical Trial

Researchers at Baylor College of Medicine, in collaboration with a team of researchers at the George Washington University and the Rene Rachou Institute, have received funding from the National Institutes of Health for a Phase Ib clinical trial for a Schistosomiasis vaccine in an endemic area of Brazil.

Schistosoma vaccine to enter phase Ib clinical trial

(George Washington University) Researchers at Baylor College of Medicine, in collaboration with a team of researchers at the George Washington University and the Rene Rachou Institute, have received funding from the National Institutes of Health for a Phase Ib clinical trial for a Schistosomiasis vaccine in an endemic area of Brazil.

Identical twins can share more than identical genes

(Baylor College of Medicine) Independent of their identical genes, identical twins share an additional level of molecular similarity that influences their biological characteristics.

Dietary sugar linked to increasing bacterial epidemics

(Baylor College of Medicine) The increasing frequency and severity of healthcare-associated outbreaks caused by bacterium Clostridium difficile have been linked to the widely used food additive trehalose.

G-quadruplex regulates breast cancer-associated gene

(Baylor College of Medicine) For breast cancer, carrying protein CD44s, instead of CD44v, has a survival advantage. Researchers have now discovered a mechanism by which cells can regulate switching between the two proteins, opening options for the development of novel therapeutic strategies to control cancer growth in the future.

Atoh1, a potential Achilles' heel of Sonic Hedgehog medulloblastoma

(Baylor College of Medicine) Tyrosine 78 in Atoh1 is phosphorylated exclusively in 'tumor-initiating cells' in sonic hedgehog medulloblastoma and reducing the levels of Atoh1 promotes tumor regression in mice and provides a potential future strategy for treating this type of tumor.

Clinicians Who Ignore Nitric Oxide (NO) Function Put Their Patients at Risk

Dr. Nathan Bryan, Baylor College of Medicine and one of the leading experts in nitric oxide biochemistry and physiology said today, "healthcare providers, especially those helping patients with cardiovascular issues and age-related disease, are not using perhaps the most important 'tool' in their 'toolbox,' restoring nitric oxide function. Show More Summary

Pediatric immunologist Jordan S. Orange recognized for healing through research

(The Academy of Medicine, Engineering & Science of Texas) Jordan Scott Orange, M.D., Ph.D., of Baylor College of Medicine is the recipient of the 2018 Edith and Peter O'Donnell Award in Medicine from The Academy of Medicine, Engineering and Science of Texas (TAMEST).

How having too much or too little of CHRNA7 can lead to neuropsychiatric disorders

(Baylor College of Medicine) Using new pluripotent stem cell technology, researchers have discovered unexpected effects on calcium flux on neurons from patients with neuropsychiatric disorders carrying either fewer or extra copies of the CHRNA7 gene.

Baylor researchers recognized with prestigious AAAS honor

(Baylor College of Medicine) Two Baylor College of Medicine researchers have been named 2017 Fellows of the American Association for the Advancement of Science.

American Heart Association Scientific Sessions 2017

(Baylor College of Medicine) A team of researchers at Baylor College of Medicine, the Texas Heart Institute and Baylor College of Medicine's Cardiovascular Research Institute has found that ciprofloxacin, a widely prescribed antibiotic,...Show More Summary

Defects in cell's 'waste disposal system' linked to Parkinson's

(Baylor College of Medicine) Research points at a group of lysosomal storage disorder genes as potential major contributors to the onset and progression of Parkinson's disease.

Chromosome organization emerges from 1-D patterns

The DNA in a human cell is 2 yards (1.83 meters) long and wraps around millions of bead-like histone proteins to fit inside the cell's nucleus. Researchers at Rice University and Baylor College of Medicine showed that examining the chemical state of these proteins makes it possible to predict how an entire DNA chromosome will fold.

Chromosome organization emerges from 1-D patterns

(Rice University) Researchers at Rice University and Baylor College of Medicine have developed a method to predict how a human chromosome folds based solely on the epigenetic marks that decorate chromatin inside cells.

2017 San Antonio Breast Cancer Symposium to be held Dec. 5-9

(American Association for Cancer Research) The UT Health San Antonio Cancer Center, the American Association for Cancer Research, and Baylor College of Medicine will be hosting the 2017 San Antonio Breast Cancer Symposium, Dec. 5-9, at the Henry B. Gonzalez Convention Center.

Mechanism explains how seizures may lead to memory loss

(Baylor College of Medicine) A team of researchers reveals a mechanism that can explain how even relatively infrequent seizures can lead to long-lasting cognitive deficits in animal models.

Researchers map human genome in 4-D as it folds

A multi-institutional team spanning Baylor College of Medicine, Rice University, Stanford University and the Broad Institute of MIT and Harvard has created the first high-resolution 4-D map of genome folding, tracking an entire human genome as it folds over time. The report, which may lead to new ways of understanding genetic diseases, appears on the cover of Cell.

Breakdown of brain cells' metabolic collaboration linked to Alzheimer's disease

(Baylor College of Medicine) Researchers have discovered that impairing a critical partnership between brain cells can lead to neurodegeneration.

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