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Molecular super enhancers: A new key for targeted therapy of brain cancer in children

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Ependymoma refers to a heterogeneous group of cancers that can occur at any age and is one of the most common types of brain cancer in children. The genetic causes for its development are largely unknown and there are no targeted treatments to date. Show More Summary

Versatile cancer drugs

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Medications which block enzymes belonging to the kinase family, are among the most effective pharmaceuticals for targeted cancer therapies. Scientists at the German...Show More Summary

Caught in the act: Papillomaviruses promote non-melanoma skin cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) UV radiation has been known for a long time to be a risk factor for the development of skin cancer. Simultaneous infection with human papillomaviruses (HPV) has also been suspected to promote skin cancer, particularly in organ transplant recipients. Show More Summary

Malaria: Protective antibodies following natural infection

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) No effective vaccine exists to date against the tropical disease malaria. Scientists from the German Cancer Research Center have now studied how the human immune system responds to natural infection by the malaria parasite. Show More Summary

Misregulated protein breakdown promotes leukemias and brain cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) An enzyme that is responsible for the breakdown of specific amino acids in food plays a key role in the development of leukemias and brain cancer, scientists from the German Cancer Research Center (DKFZ) in Heidelberg have now reported in Nature. Show More Summary

Inhibitors support immune therapy for leukemia

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) New immune therapies are considered a promising lead for treating recurring acute myeloid leukemia (AML). Antibodies are able to eliminate even those cancer cells that cannot be removed via regular therapies. Show More Summary

Chronic cell death promotes liver cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Liver cancer occurs predominantly in patients whose liver has been damaged as a result of chronic disease. Scientists from the German Cancer Research Center and the University of Zurich has now shown that chronic cell death promotes the development of cancer. Show More Summary

Cancer cells put the brakes on immune system

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) In order for cancer cells to successfully spread and multiply, they must find a way to avoid the body's own immune system. Scientists at the German Cancer Research Center have published an explanation for how this occurs with chronic lymphatic leukemia (CLL).

Surprising genetic variety in childhood brain cancer

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) An international research team led by scientists from the German Cancer Research Center (DKFZ) and the Hopp Children's Tumor Center at the NCT Heidelberg (KiTZ) has identified new genetic alterations and mechanisms that lead to very aggressive types of childhood brain cancer. Show More Summary

How blood vessels slow down and accelerate tumor growth

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Scientists from the German Cancer Research Center and Heidelberg University have discovered a new mechanism that causes faster sprouting of blood vessels. Cells...Show More Summary

MRI without contrast agents? Yes, with sugar!

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Scientists from the German Cancer Research Center (DKFZ), in collaboration with colleagues from Heidelberg University Hospital, have been able to visualize brain cancer using a novel MRI method. Show More Summary

How bile duct cancer develops and how it can be prevented

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) What promotes the development of bile duct cancer in the liver? Are these factors different from those that are responsible for the much more common hepatocellular...Show More Summary

Mysterious gene transcripts after cancer therapy

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Drugs that are used in cancer therapy to erase epigenetic alterations in cancer cells simultaneously promote the production of countless mysterious gene transcripts, scientists from the German Cancer Research Center now report in Nature Genetics. Show More Summary

Blocking cancer-specific mutations in leukemia and brain tumors

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) The substitution of a single amino acid in a metabolic enzyme can be the cause of various types of cancer. Scientists from the German Cancer Research Center and...Show More Summary

Defective intercellular connections cause hydrocephalus

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) A defective gene leads to changes in the cellular layer between cerebrospinal fluid and brain nervous tissue, thus causing a buildup of fluid in the brain. This...Show More Summary

Vitamin A deficiency is detrimental to blood stem cells

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Lack of vitamin A in the body has a detrimental effect on the hematopoietic system in the bone marrow. The deficiency causes a loss of important blood stem cells,...Show More Summary

Peptide acts as mediator for learning

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) In order to adapt to changes in the environment, the brain produces new nerve cells even at adult age. These young neurons are crucial for memory formation and learning. Show More Summary

A biomarker for cancer of the oropharynx

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) A growing number of cases of oropharyngeal cancer are considered to be a consequence of infection with human papillomaviruses (HPV). Scientists at the German Cancer...Show More Summary

Antibody is effective against radiation-induced pulmonary fibrosis

10 months agoHealth : EurekAlert: Health

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Radiation therapy of the lungs often leads to irreversible connective-tissue changes that cause functional impairments in the pulmonary tissue. Scientists from the German Cancer Research Center (DKFZ) have now been able to prevent, and even reverse this process in mice using an antibody.

DNA labels predict mortality

(German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ)) Methyl labels in the DNA regulate the activity of our genes and, thus, have a great influence on health and disease. Scientists from the German Cancer ResearchShow More Summary

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