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Biomarker, clues to possible therapy found in novel childhood neurogenetic disease

(Children's Hospital of Philadelphia) Researchers studying a rare genetic disorder that causes severe, progressive neurological problems in childhood have discovered insights into biological mechanisms that drive the disease, along with early clues that an amino acid supplement might offer a targeted therapy. Show More Summary

Hearing loss is common after infant heart surgery

(Children's Hospital of Philadelphia) Children who have heart surgery as infants are at risk for hearing loss, coupled with associated risks for language, attention and cognitive problems, by age four. In a cohort of 348 preschoolers...Show More Summary

T cell therapy shows persistent benefits in young leukemia patients

(Children's Hospital of Philadelphia) Updated results from a global clinical trial of the CAR T-cell therapy, tisagenlecleucel, a landmark personalized treatment for a high-risk form of acute lymphoblastic leukemia (ALL), reveal that children and young adults continued to show high rates of durable, complete remission of their disease. Show More Summary

For children with respiratory infections, antibiotics with narrower targets are better

(Children's Hospital of Philadelphia) When doctors prescribe antibiotics for children with common respiratory infections, a more selective approach is better. A study of 30,000 children with earaches, strep throat and other common infections...Show More Summary

Can vitamins and dietary supplements benefit patients with mitochondrial disease?

(Children's Hospital of Philadelphia) Defects in mitochondria, the tiny structures that power cells by functioning as biological batteries, cause an array of complex disorders that can affect any and all organs and systems. In the absence...Show More Summary

FDA approves gene therapy for inherited blindness developed by the University of Pennsylvania and Children's Hospital of Philadelphia

(University of Pennsylvania School of Medicine) In a historic move, the US Food and Drug Administration (FDA) today approved a gene therapy initially developed by researchers at the University of Pennsylvania and Children's Hospital of Philadelphia (CHOP) for the treatment of a rare, inherited form of retinal blindness. Show More Summary

FDA Approves Gene Therapy for Inherited Blindness Developed by the University of Pennsylvania and Children's Hospital of Philadelphia

In a historic move, the U.S. Food and Drug Administration (FDA) today approved a gene therapy initially developed by researchers at the University of Pennsylvania and Children's Hospital of Philadelphia (CHOP) for the treatment of a rare, inherited form of retinal blindness. Show More Summary

Brain remaps itself in child with double hand transplant

(Children's Hospital of Philadelphia) The first child to undergo a successful hand transplant also is the first child in whom scientists have detected massive changes in how sensations from the hands are represented in the brain. The...Show More Summary

CHOP researchers highlight advances in pediatric heart disease at 2017 AHA scientific sessions

(Children's Hospital of Philadelphia) Physician-researchers from the Cardiac Center at Children's Hospital of Philadelphia (CHOP) recently presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions 2017 in Anaheim, Calif. Show More Summary

Researchers from Children's Hospital of Philadelphia Highlight Advances in Pediatric Heart Disease at 2017 A.H.A. Scientific Sessions

Physician-researchers from the Cardiac Center at Children's Hospital of Philadelphia recently presented new findings on pediatric cardiovascular disease at the American Heart Association's Scientific Sessions 2017 in Anaheim, Calif.Show More Summary

Genetic predisposition to later puberty causes lower bone density in children and adults

(Children's Hospital of Philadelphia) People whose genetic makeup triggers a later-than-average start to puberty have lower bone mineral density, especially in their lower spine. Because adolescence is a critical period for accruing bone, this effect may increase a person's risk of osteoporosis and bone fractures later in life.

Twins born joined at the head go home after 485 days

Twins born joined at the head have gone home to North Carolina, four months after surgery in Philadelphia separated them. The Charlotte Observer reports that Erin and Abby Delaney left the Children's Hospital of Philadelphia on Monday morning after 485 days. Their parents, Heather and Riley Delaney,...

These conjoined twins spent their lives in a hospital. They just went home — as two.

3 months agoHealth : The Checkup

Abby and Erin Delaney have gone home — months after being separated in a rare surgery at Children’s Hospital of Philadelphia.

Parent-supplied photos allow pediatric dermatology diagnoses with no office visit in most cases

(Children's Hospital of Philadelphia) Using smartphone cameras, parents can reliably take high-quality photographs of their child's skin condition to send to a dermatologist for diagnosis. This finding suggests that direct-to-patient dermatology can accurately provide pediatric dermatology care.

Mindfulness may help mothers cope with stress when their babies have a heart condition

(Children's Hospital of Philadelphia) Mindfulness may offer an active coping mechanism for mothers faced with the stress of having a newborn diagnosed with congenital heart disease (CHD). Mindfulness, which aims to increase a person's...Show More Summary

New network will advance treatments for children

(Children's Hospital of Philadelphia) For a variety of reasons, medications and devices specifically developed for children have traditionally lagged behind similar products for adults. A new federally funded program intends to address...Show More Summary

New clinical care guidelines issued for patients with mitochondrial disease

(Children's Hospital of Philadelphia) Physicians who see patients with mitochondrial disease now have a practical new tool -- a set of guidelines for managing and caring for those patients. Occurring in at least one in 4,500 individuals,...Show More Summary

Biology of childhood brain tumor subtypes offers clues to precision treatments

(Children's Hospital of Philadelphia) Researchers investigating pediatric low-grade gliomas (PLGG), the most common type of brain tumor in children, have discovered key biological differences in how mutated genes combine with other genes to drive this childhood cancer. Show More Summary

Two firms awarded seed grants to develop medical devices for children

(Children's Hospital of Philadelphia) The Philadelphia Pediatric Medical Device Consortium has announced its latest round of seed grants to companies developing medical devices for children. The devices are a speech generating system...Show More Summary

Two Firms Awarded Seed Grants to Develop Medical Devices for Children

The Philadelphia Pediatric Medical Device Consortium (PPDC) has announced its latest round of seed grants to companies developing medical devices for children. The devices are a speech generating system that allows hospitalized children who cannot speak to communicate to clinicians, and a handheld scanner to detect intracranial bleeding in children, without using radiology.

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