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Study shows higher risk of Dementia for adults with congenital heart disease

(Cincinnati Children's Hospital Medical Center) A new study is believed to be the first to show a higher risk of dementia in adults who were born with heart disease. The study of more than 10,000 adult with congenital heart disease (CHD) in Denmark discovered a particularly increased risk for early dementia in middle-age adults.

Understanding a fly's body temperature may help people sleep better

(Cincinnati Children's Hospital Medical Center) In findings that one day may help people sleep better, scientists have uncovered the first molecular evidence that two anciently conserved proteins in the brains of insects and mammals share a common biological ancestry as regulators of body temperature rhythms crucial to metabolism and sleep. Show More Summary

Study suggests way to attack deadly, untreatable nerve tumors

(Cincinnati Children's Hospital Medical Center) Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell. Show More Summary

Experimental therapy restores nerve insulation damaged by disease

(Cincinnati Children's Hospital Medical Center) When the body attacks its own healthy tissues in an autoimmune disease, peripheral nerve damage handicaps people and causes persistent neuropathic pain when insulation on healing nerves doesn't fully regenerate. Show More Summary

Direct link between glands and implanting embryos critical to pregnancy

(Cincinnati Children's Hospital Medical Center) Researchers used 3-D imaging with molecular testing to uncover new insight into the earliest stages of mammalian pregnancy -- offering clues to unsolved questions in pregnancy. Reporting Feb. Show More Summary

Search for genetically stable bioengineered gut and liver tissue takes step forward

(Cincinnati Children's Hospital Medical Center) Before medical science can bioengineer human organs in a lab for therapeutic use, two remaining hurdles are ensuring genetic stability -- so the organs are free from the risk of tumor growth -- and producing organ tissues of sufficient volume and size for viable transplant into people. Show More Summary

Scientists discover how gene mutation triggers immune disease

(Cincinnati Children's Hospital Medical Center) Scientists discovered how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery--successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia. Show More Summary

Study reveals abnormalities in infants born in withdrawal after opioid exposure in utero

(Cincinnati Children's Hospital Medical Center) A new study of infants born in withdrawal due to opioid exposure in utero shows a dramatic increase in torticollis -- an abnormal twisting of the neck. Many of the infants also had plagiocephaly -- a flattening of the head often seen in conjunction with torticollis.

Study explores impact of obesity on bone marrow cells

(Cincinnati Children's Hospital Medical Center) New research published in the Journal of Experimental Medicine highlights the pernicious effect of obesity on the long-term health of blood-making stem cells (hematopoietic stem cells)....Show More Summary

Exposure to air pollution just before or after conception raises risk of birth defects

(Cincinnati Children's Hospital Medical Center) Women exposed to air pollution just prior to conception or during the first month of pregnancy face an increased risk of their children being born with birth defects, such as cleft lip or palate or abnormal hearts.

Study raises possibility of naturally acquired immunity against Zika virus

(Cincinnati Children's Hospital Medical Center) Birth defects in babies born infected with Zika virus remain a major health concern. Now, scientists suggest the possibility that some women in high-risk Zika regions may already be protected and not know it. Show More Summary

Cincinnati children's research paves way for newly approved asthma drug

(Cincinnati Children's Hospital Medical Center) Thanks in part to nearly two decades of research at Cincinnati Children's Hospital Medical Center, the FDA has approved benralizumab, the first drug designed to specifically deplete eosinophils as a treatment for asthma.

Cincinnati Children's launches Center for Stem Cell and Organoid Medicine

(Cincinnati Children's Hospital Medical Center) Seven years ago Cincinnati Children's scientists first used pluripotent stem cells to mimic natural human development and grow working human intestine in a lab. Today medical center doctors...Show More Summary

New study examines value of routine laboratory screenings for children entering foster care

(Cincinnati Children's Hospital Medical Center) Routine laboratory screening recommended for children entering foster care carries high costs and questionable medical benefits.

Study explores the biology of mending a broken heart

(Cincinnati Children's Hospital Medical Center) Early research results suggest scientists might be on to a way to preserve heart function after heart attacks or for people with inherited heart defects called congenital cardiomyopathies. Show More Summary

Researchers raise health concerns about off-road vehicles and inhalation of asbestos

(Cincinnati Children's Hospital Medical Center) Preventing injuries may not be the only reason children shouldn't use off-road vehicles (ORVs). In a new study, public health scientists raise concerns that people who use ORVs in many regions of the country may face exposure to hazardous mineral fibers.

Obesity prevention guidelines are not followed for preschool children

(Cincinnati Children's Hospital Medical Center) In a study of nearly 400 preschool children, only one child adhered to obesity prevention guidelines over the course of a single day at child care and at home.

Study hints at experimental therapy for heart fibrosis

(Cincinnati Children's Hospital Medical Center) Researchers report encouraging preclinical results as they pursue elusive therapies that can repair scarred and poorly functioning heart tissues after cardiac injury. Scientists from the...Show More Summary

Study identifies tools to identify patients at risk for autism spectrum disorders

(Cincinnati Children's Hospital Medical Center) A tool intended to detect signs of autism in high-risk infants can be used to help identify and treat patients with tuberous sclerosis complex, a genetic disorder, who most need early intervention. Moreover, they can identify these patients earlier than ever before.

Taking medications as prescribed important to control health care costs

(Cincinnati Children's Hospital Medical Center) At a time when health care costs are scrutinized more closely than ever, a new study demonstrates the importance of taking medications as prescribed to control costs.

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